PMID- 3348442
OWN - NLM
STAT- MEDLINE
DCOM- 19880419
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 254
IP  - 3 Pt 2
DP  - 1988 Mar
TI  - Decreased hexokinase activity in paraventricular nucleus of adult SHR and renal 
      hypertensive rats.
PG  - R508-12
AB  - Metabolic activity was assessed in the brains of spontaneously hypertensive rats 
      (SHR) using the histochemical hexokinase (HK) technique and photodensitometric 
      analysis. Of eight regions known to play a role in cardiovascular regulation, 
      only the paraventricular nucleus of the hypothalamus (PVH) exhibited alterations 
      in HK activity. Significantly lower levels of HK activity in SHR than in control 
      Sprague-Dawley and Wistar-Kyoto rats were measured in both the parvo- and 
      magnocellular divisions of the PVH. No differences in HK activity were found in 
      the anterior hypothalamic nucleus, posterior hypothalamic nucleus, supraoptic 
      nucleus, subfornical organ, central nucleus of the amygdala, or the medial 
      nucleus of the tractus solitarius of SHR. Similar results were obtained in renal 
      hypertensive rats; furthermore, a positive correlation was found between levels 
      of arterial pressure and densitometric readings. These latter results strongly 
      suggest that metabolic alterations in the PVH of SHR are directly related to the 
      increases in arterial pressure and are not due to the genetic makeup of SHR. In 
      light of studies by others, the data from the present study have been interpreted 
      to suggest that the decreases in metabolic activity in the PVH of the adult SHR 
      are the result of a central attempt to bring the level of the arterial pressure 
      down to normal levels and not to the altered activity of a region that might be 
      acting to keep arterial pressure elevated.
FAU - Krukoff, T L
AU  - Krukoff TL
AD  - Department of Anatomy and Cell Biology, Faculty of Medicine, University of 
      Alberta, Edmonton, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
MH  - Animals
MH  - Densitometry
MH  - Hexokinase/*metabolism
MH  - Histocytochemistry
MH  - Hypertension/*enzymology
MH  - Hypertension, Renal/*enzymology
MH  - Male
MH  - Paraventricular Hypothalamic Nucleus/*enzymology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred Strains
MH  - Rats, Inbred WKY
EDAT- 1988/03/01 00:00
MHDA- 1988/03/01 00:01
CRDT- 1988/03/01 00:00
PHST- 1988/03/01 00:00 [pubmed]
PHST- 1988/03/01 00:01 [medline]
PHST- 1988/03/01 00:00 [entrez]
AID - 10.1152/ajpregu.1988.254.3.R508 [doi]
PST - ppublish
SO  - Am J Physiol. 1988 Mar;254(3 Pt 2):R508-12. doi: 10.1152/ajpregu.1988.254.3.R508.