PMID- 33484721 OWN - NLM STAT- MEDLINE DCOM- 20210421 LR - 20220402 IS - 1096-0953 (Electronic) IS - 0013-9351 (Print) IS - 0013-9351 (Linking) VI - 195 DP - 2021 Apr TI - Adipose to serum ratio and mixtures of persistent organic pollutants in relation to endometriosis: Findings from the ENDO Study. PG - 110732 LID - S0013-9351(21)00026-8 [pii] LID - 10.1016/j.envres.2021.110732 [doi] AB - BACKGROUND: Endometriosis is an estrogen-dependent disease. Endocrine disrupting chemicals (EDCs) and their mixtures may play an etiologic role. OBJECTIVES: We evaluated an adipose-to-serum ratio (ASR) of lipophilic EDCs and their mixtures associated with incident endometriosis. METHODS: We quantified 13 polychlorinated biphenyl (PCB) congeners, 6 polybrominated diphenyl ether (PBDE) congeners, and 11 organochlorine pesticides (OCPs) in serum and omental fat among women from the ENDO Study (2007-2009) aged 18-44 years diagnosed with (n=190) or without (n=283) surgically-visualized incident endometriosis. Odds ratios (OR) and 95% confidence intervals (CI) between ASR and endometriosis were estimated using logistic regression models adjusted for age (years), body mass index (kg/m(2)), serum cotinine (ng/ml), and breastfeeding conditional on parity. Bayesian hierarchical models (BHM) compared estimated associations for adipose and ASR to serum. Bayesian kernel machine regression (BKMR) estimated change in latent health and 95% posterior intervals (PI) between chemical mixtures and endometriosis. RESULTS: Select ASR for estrogenic PCBs and OCPs were associated with an increased odds of an endometriosis diagnosis, but not for anti-estrogenic PCBs or PBDEs. Across all chemicals, BHMs generated ORs that were on average 14% (95% PI: 6%, 22%) higher for adipose and 20% (95% PI: 12%, 29%) higher for ASR in comparison to serum. ORs from BHMs were greater for estrogenic PCBs and OCPs, with no differences for PBDEs. BKMR models comparing the 75th to 25th percentile were moderately associated with endometriosis for estrogenic PCBs [adipose 0.27 (95% PI: 0.18, 0.72) and ASR 0.37 (95% PI: 0.06, 0.80)] and OCPs [adipose 0.17 (95% PI: 0.21, 0.56) and ASR 0.26 (95% PI: 0.05, 0.57)], but not for antiestrogenic PCBs and PBDEs. DISCUSSION: ASR added little insight beyond adipose for lipophilic chemicals. BKMR results supported associations between ASR and adipose estrogenic PCB and OCP mixtures and incident endometriosis. These findings underscore the importance of choice of biospecimen and considering mixtures when assessing exposure-disease relationships. CI - Copyright (c) 2021 Elsevier Inc. All rights reserved. FAU - Pollack, Anna Z AU - Pollack AZ AD - Department of Global and Community Health, College of Health and Human Services George Mason University, Fairfax, VA, 22030, USA. Electronic address: apollac2@gmu.edu. FAU - Krall, Jenna R AU - Krall JR AD - Department of Global and Community Health, College of Health and Human Services George Mason University, Fairfax, VA, 22030, USA. FAU - Kannan, Kurunthachalam AU - Kannan K AD - Department of Pediatrics and Department of Environmental Medicine, New York University School of Medicine, New York, NY, 10016, USA. FAU - Buck Louis, Germaine M AU - Buck Louis GM AD - College of Health and Human Services George Mason University, Fairfax, VA, 22030, USA. LA - eng GR - R01 ES031079/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, N.I.H., Intramural DEP - 20210121 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Environmental Pollutants) RN - 0 (Halogenated Diphenyl Ethers) RN - 0 (Hydrocarbons, Chlorinated) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Adolescent MH - Adult MH - Bayes Theorem MH - *Endometriosis/chemically induced/epidemiology MH - *Environmental Pollutants/analysis MH - Female MH - Halogenated Diphenyl Ethers/toxicity MH - Humans MH - *Hydrocarbons, Chlorinated/analysis MH - Persistent Organic Pollutants MH - *Polychlorinated Biphenyls/toxicity MH - Pregnancy MH - Young Adult PMC - PMC8432300 MID - NIHMS1666796 OTO - NOTNLM OT - Endocrine disrupting chemicals OT - Endometriosis OT - Mixtures OT - Omental adipose OT - Organochlorine pesticide OT - Polybrominated diphenyl ether OT - Polychlorinated biphenyl COIS- Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2021/01/24 06:00 MHDA- 2021/04/22 06:00 PMCR- 2022/04/01 CRDT- 2021/01/23 20:08 PHST- 2020/09/14 00:00 [received] PHST- 2020/12/14 00:00 [revised] PHST- 2021/01/07 00:00 [accepted] PHST- 2021/01/24 06:00 [pubmed] PHST- 2021/04/22 06:00 [medline] PHST- 2021/01/23 20:08 [entrez] PHST- 2022/04/01 00:00 [pmc-release] AID - S0013-9351(21)00026-8 [pii] AID - 10.1016/j.envres.2021.110732 [doi] PST - ppublish SO - Environ Res. 2021 Apr;195:110732. doi: 10.1016/j.envres.2021.110732. Epub 2021 Jan 21.