PMID- 3348490
OWN - NLM
STAT- MEDLINE
DCOM- 19880418
LR  - 20170214
IS  - 0003-3197 (Print)
IS  - 0003-3197 (Linking)
VI  - 39
IP  - 2
DP  - 1988 Feb
TI  - High 2,3-DPG blood cardioplegia and myocardial preservation during 
      cardiopulmonary bypass.
PG  - 123-31
AB  - Blood may provide superior cardioplegia compared with crystalloid cardioplegic 
      solution. However, the results are controversial. This may be due to a leftward 
      shift of the hemoglobin (Hb)-O2 dissociation curve induced by hypothermia, 
      increasing the oxygen affinity for Hb. This effect may negate the potential 
      benefit of blood cardioplegia. The oxygen affinity for Hb can be decreased by 
      increasing the red cell 2,3-diphosphoglycerate (2,3-DPG), and hence, more oxygen 
      can be delivered to the myocardium. The present investigation was undertaken to 
      study the effects of 2,3-DPG-enriched blood cardioplegia on the functional 
      recovery of the myocardium and changes in the coronary sinus red blood cell (RBC) 
      adenosine-triphosphate (ATP), lactate, and RBC DPG after one and a half hours of 
      reperfusion following one hour of ischemic cardiac arrest in dogs. The dogs were 
      divided into three groups: crystalloid (CR); stored blood (SB), and high 2,3-DPG 
      blood (HDPG) cardioplegic groups. Incubation of canine RBC in phosphoenal 
      pyruvate (PEP) led to a 36% increase in DPG and a rightward shift in the Hb-O2 
      dissociation curve. There was a 4 mm Hg shift in the P50. When compared with the 
      CR group, there was a significant decrease in the cardiac index (CI) and left 
      ventricular work index (LVWI) and a significant increase in the total systemic 
      vascular resistance (TSVR) in the SB group. The CI and LVWI of the HDPG group 
      were similar to those of the CR group, but the TSVR was significantly greater in 
      the former group. The LVWI was significantly greater and the TSVR smaller in the 
      HDPG group as compared with those in the SB group.(ABSTRACT TRUNCATED AT 250 
      WORDS)
FAU - Card, R T
AU  - Card RT
AD  - Department of Physiology, College of Medicine, University of Saskatchewan, 
      Saskatoon, Canada.
FAU - Prasad, K
AU  - Prasad K
FAU - Bharadwaj, B
AU  - Bharadwaj B
FAU - Hnatuk, L A
AU  - Hnatuk LA
FAU - MacFadyen, M A
AU  - MacFadyen MA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
RN  - 0 (Diphosphoglyceric Acids)
RN  - 0 (Hemoglobins)
RN  - 0 (Lactates)
RN  - 0 (Potassium Compounds)
RN  - 0 (potassium cardioplegic solution)
RN  - 138-81-8 (2,3-Diphosphoglycerate)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - 2,3-Diphosphoglycerate
MH  - Adenosine Triphosphate/blood
MH  - Animals
MH  - *Blood
MH  - Blood Preservation
MH  - *Cardiopulmonary Bypass
MH  - Coronary Vessels
MH  - *Diphosphoglyceric Acids
MH  - Dogs
MH  - Erythrocytes/metabolism
MH  - Female
MH  - Heart/*physiology
MH  - Heart Arrest, Induced/*methods
MH  - Hemodynamics
MH  - Hemoglobins/analysis
MH  - Humans
MH  - Lactates/blood
MH  - Male
MH  - Myocardium/metabolism
MH  - Potassium
MH  - *Potassium Compounds
MH  - Veins
EDAT- 1988/02/01 00:00
MHDA- 1988/02/01 00:01
CRDT- 1988/02/01 00:00
PHST- 1988/02/01 00:00 [pubmed]
PHST- 1988/02/01 00:01 [medline]
PHST- 1988/02/01 00:00 [entrez]
AID - 10.1177/000331978803900201 [doi]
PST - ppublish
SO  - Angiology. 1988 Feb;39(2):123-31. doi: 10.1177/000331978803900201.