PMID- 33486266
OWN - NLM
STAT- MEDLINE
DCOM- 20210426
LR  - 20220223
IS  - 1618-095X (Electronic)
IS  - 0944-7113 (Linking)
VI  - 82
DP  - 2021 Feb
TI  - Herbal formula MaZiRenWan (Hemp Seed Pill) for constipation: A systematic review 
      with meta-analysis.
PG  - 153459
LID - S0944-7113(21)00001-5 [pii]
LID - 10.1016/j.phymed.2021.153459 [doi]
AB  - BACKGROUND: There is growing interest in using herbal supplements to treat 
      constipation; however, little evidence exists for their use. PURPOSE: This study 
      evaluates the efficacy and safety of herbal formula MaZiRenWan (Hemp Seed Pill, 
      HSP) in patients with functional or non-functional constipation. STUDY DESIGN: 
      Systematic review and meta-analysis METHODS: PubMed, CENTRAL, Embase, CNKI, and 
      Wanfang were searched through April 20, 2020 for randomized trials of HSP versus 
      placebo or medications for all types of constipation. The primary outcomes were 
      complete response rate, complete spontaneous bowel movement (CSBM), 
      patient-reported satisfactory treatment rate (prSTR), and adverse events (AEs). 
      Clinical data were analyzed using a random-effects model, and the quality of 
      evidence was evaluated with the GRADE system. RESULTS: This review includes 1681 
      constipation patients from 17 moderate-to-high risk of bias trials that were 
      conducted in east Asia. Two high-quality trials showed that HSP compared with 
      placebo significantly increased weekly CSBM (mean difference, 0.95; 95% CI: 0.56, 
      1.35) and had a higher complete response rate (risk ratio [RR], 1.43; 95% CI: 
      1.20, 1.71) in patients with functional constipation. Low-quality evidence showed 
      significant improvement in prSTR in HSP compared with conventional medications 
      (RR, 1.79; 95% CI: 1.42, 2.25). Additionally, HSP use did not increase AEs 
      compared with no HSP (p = 0.99). CONCLUSIONS: This study found that HSP was 
      effective among Asian patients with functional constipation. Rigorous trials need 
      to be conducted in clinical populations outside of east Asia and in those with 
      non-functional constipation to increase the generalizability of the evidence.
CI  - Copyright (c) 2021. Published by Elsevier GmbH.
FAU - Yang, Mingxiao
AU  - Yang M
AD  - Memorial Sloan Kettering Cancer Center, Bendheim Integrative Medicine Center, 
      1429 First Avenue, New York, NY, 10021, United States.
FAU - Feng, Ye
AU  - Feng Y
AD  - Memorial Sloan Kettering Cancer Center, Bendheim Integrative Medicine Center, 
      1429 First Avenue, New York, NY, 10021, United States; Department of Integration 
      of Chinese and Western Medicine, Key Laboratory of Carcinogenesis and 
      Translational Research (Ministry of Education, Beijing), Peking University Cancer 
      Hospital & Institute, Beijing 100142, China.
FAU - Zhang, Yi Lily
AU  - Zhang YL
AD  - Memorial Sloan Kettering Cancer Center, Bendheim Integrative Medicine Center, 
      1429 First Avenue, New York, NY, 10021, United States.
FAU - Smith, Colleen M
AU  - Smith CM
AD  - Memorial Sloan Kettering Cancer Center, Bendheim Integrative Medicine Center, 
      1429 First Avenue, New York, NY, 10021, United States.
FAU - Hou, Yen-Nien
AU  - Hou YN
AD  - Memorial Sloan Kettering Cancer Center, Bendheim Integrative Medicine Center, 
      1429 First Avenue, New York, NY, 10021, United States.
FAU - Wang, Hui
AU  - Wang H
AD  - Memorial Sloan Kettering Cancer Center, Bendheim Integrative Medicine Center, 
      1429 First Avenue, New York, NY, 10021, United States; Department of Oncology, 
      Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, 
      Xicheng District, Beijing, 100053, China.
FAU - Deng, Gary
AU  - Deng G
AD  - Memorial Sloan Kettering Cancer Center, Bendheim Integrative Medicine Center, 
      1429 First Avenue, New York, NY, 10021, United States.
FAU - Mao, Jun J
AU  - Mao JJ
AD  - Memorial Sloan Kettering Cancer Center, Bendheim Integrative Medicine Center, 
      1429 First Avenue, New York, NY, 10021, United States. Electronic address: 
      maoj@mskcc.org.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20210105
PL  - Germany
TA  - Phytomedicine
JT  - Phytomedicine : international journal of phytotherapy and phytopharmacology
JID - 9438794
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (ma zi ren wan)
SB  - IM
MH  - Constipation/*drug therapy
MH  - Defecation/drug effects
MH  - Dietary Supplements
MH  - Drugs, Chinese Herbal/adverse effects/pharmacology/*therapeutic use
MH  - Humans
OTO - NOTNLM
OT  - Constipation
OT  - Efficacy
OT  - MaZiRenWan
OT  - Safety
EDAT- 2021/01/25 06:00
MHDA- 2021/04/27 06:00
CRDT- 2021/01/24 20:39
PHST- 2020/09/22 00:00 [received]
PHST- 2020/12/17 00:00 [revised]
PHST- 2021/01/01 00:00 [accepted]
PHST- 2021/01/25 06:00 [pubmed]
PHST- 2021/04/27 06:00 [medline]
PHST- 2021/01/24 20:39 [entrez]
AID - S0944-7113(21)00001-5 [pii]
AID - 10.1016/j.phymed.2021.153459 [doi]
PST - ppublish
SO  - Phytomedicine. 2021 Feb;82:153459. doi: 10.1016/j.phymed.2021.153459. Epub 2021 
      Jan 5.