PMID- 33487800
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230923
IS  - 0253-7176 (Print)
IS  - 0975-1564 (Electronic)
IS  - 0253-7176 (Linking)
VI  - 42
IP  - 6 Suppl
DP  - 2020 Dec
TI  - Managing Depression in Diabetes Mellitus: A Multicentric Randomized Controlled 
      Trial Comparing Effectiveness of Fluoxetine and Mindfulness in Primary Care: 
      Protocol for DIAbetes Mellitus ANd Depression (DIAMAND) Study.
PG  - S31-S38
LID - 10.1177/0253717620971200 [doi]
AB  - BACKGROUND: Suboptimal management of depression in type 2 diabetes mellitus 
      (T2DM) often translates into poor glycemic control, medical complications, and 
      impaired quality of life. Feasibility and effectiveness of collaborative care 
      models of depression in diabetes in low- and middle-income countries (LMICs) 
      remain unexplored. DIAbetes Mellitus ANd Depression (DIAMAND) study, a 
      multicentric single-blind randomized controlled trial (SBRCT) comparing 
      effectiveness of fluoxetine and mindfulness in primary care settings, addresses 
      this gap in scientific literature. METHODS: This trial conducted in diverse 
      geographic settings of New Delhi, Bengaluru, and Bhubaneswar will comprise 
      module-based training of primary care providers (PCPs) for screening, diagnosing, 
      and managing depression in diabetes in phase I. Phase II will involve four-arm 
      parallel group RCT on 350 participants with T2DM with comorbid depressive episode 
      randomly allocated to receive fluoxetine, mindfulness therapy, fluoxetine plus 
      mindfulness therapy, or treatment as usual at primary care settings. 
      Interventions would include fluoxetine (up to 60 mg/day) and/or sessions of 
      mindfulness for 16 weeks. Primary outcomes on standardized rating scales include 
      depression scores (Hamilton Depression Rating Scale), treatment adherence 
      (Adherence to Refill and Medication Scale), self-care (Diabetes Self-Management 
      Questionnaire), diabetes-related distress (Diabetes Distress Scale), and glycemic 
      control. Secondary outcomes include quality of life (World Health Organization 
      Quality of Life Brief version [WHO-QOL BREF]) and mindfulness (Five Facets 
      Mindfulness Questionnaire). DISCUSSION: This RCT will investigate the 
      effectiveness of module-based training of PCPs and feasibility of collaborative 
      care model for managing depression in T2DM in primary care settings in LMICs and 
      effectiveness of fluoxetine and/or mindfulness in improving diverse outcomes of 
      T2DM with major depression.
CI  - (c) 2020 Indian Psychiatric Society - South Zonal Branch.
FAU - Chandra, Mina
AU  - Chandra M
AD  - Dept. of Psychiatry, Deaddiction Services & Resource Centre for Tobacco Control, 
      Centre of Excellence in Mental Health, Atal Bihari Vajpayee Institute of Medical 
      Sciences (Formerly PGIMER) and Dr Ram Manohar Lohia Hospital, New Delhi, India.
FAU - Raveendranathan, Dhanya
AU  - Raveendranathan D
AD  - Dept. of Psychiatry, St. John's Medical College, Bengaluru, Karnataka, India.
FAU - Johnson Pradeep R
AU  - Johnson Pradeep R
AUID- ORCID: 0000-0003-0758-1664
AD  - Dept. of Psychiatry, Medical Ethics, Institutional Ethics Committee, St. John's 
      Medical College, Bengaluru, Karnataka, India.
FAU - Patra, Suravi
AU  - Patra S
AUID- ORCID: 0000-0001-6017-5222
AD  - Dept. of Psychiatry, AIIMS Bhubaneswar, Bhubaneswar, Odisha, India.
FAU - Rushi
AU  - Rushi
AD  - Dept. of Clinical Psychology, Centre of Excellence in Mental Health, Deaddiction 
      Services & Resource Centre for Tobacco Control, Atal Bihari Vajpayee Institute of 
      Medical Sciences (Formerly PGIMER) and Dr Ram Manohar Lohia Hospital, New Delhi, 
      India.
FAU - Prasad, Konasale
AU  - Prasad K
AD  - Dept. of Psychiatry and Bioengineering, University of Pittsburgh, Veterans 
      Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.
FAU - Brar, Jaspreet S
AU  - Brar JS
AD  - Dept. of Psychiatry, Community Care Behavioral Health Organization, Western 
      Psychiatric Hospital of UPMC, Pittsburgh, Pennsylvania, USA.
LA  - eng
GR  - D43 TW009114/TW/FIC NIH HHS/United States
PT  - Journal Article
DEP - 20201207
PL  - United States
TA  - Indian J Psychol Med
JT  - Indian journal of psychological medicine
JID - 7910727
PMC - PMC7802038
OTO - NOTNLM
OT  - Collaborative care
OT  - depression
OT  - mindfulness
OT  - randomized controlled trial
OT  - type 2 diabetes mellitus
COIS- The authors declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2021/01/26 06:00
MHDA- 2021/01/26 06:01
PMCR- 2020/12/07
CRDT- 2021/01/25 05:36
PHST- 2021/01/25 05:36 [entrez]
PHST- 2021/01/26 06:00 [pubmed]
PHST- 2021/01/26 06:01 [medline]
PHST- 2020/12/07 00:00 [pmc-release]
AID - 10.1177_0253717620971200 [pii]
AID - 10.1177/0253717620971200 [doi]
PST - ppublish
SO  - Indian J Psychol Med. 2020 Dec;42(6 Suppl):S31-S38. doi: 
      10.1177/0253717620971200. Epub 2020 Dec 7.