PMID- 33488313
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210126
IS  - 1559-3258 (Print)
IS  - 1559-3258 (Electronic)
IS  - 1559-3258 (Linking)
VI  - 18
IP  - 4
DP  - 2020 Oct-Dec
TI  - Protective Effect of S-Allyl Cysteine Against Neonatal Asthmatic Rats.
PG  - 1559325820982189
LID - 10.1177/1559325820982189 [doi]
LID - 1559325820982189
AB  - S-Allyl cysteine (SAC), an organic compound and a natural constituent of Allium 
      sativum, commonly known as garlic have been consumed in routine foods are known 
      to possess various biological activities. Nevertheless, scientific evidence on 
      the protective effect of SAC against neonatal asthmatic rats is not available. 
      Hence, the present study aimed at investigating the anti-asthmatic activity of 
      SAC in neonatal asthmatic rats using Wistar rats. The study conducted in 4 groups 
      consists of normal control rats, asthma-induced, asthma animals administered with 
      SAC (25 mg/kg), and SAC control. At the end of the experimental period, 
      inflammatory cells in bronchoalveolar lavage fluid (BALF), inflammatory markers, 
      fibrinogen level, activated partial thromboplastin time, coagulation factor 
      activity, and histopathology were elucidated. The current investigation exhibits 
      that SAC significantly reduced the total leukocytes, with restored fibrinogen 
      level, and activated partial thromboplastin time. In addition, the levels of 
      inflammatory cytokines such as TNF-alpha (tumor necrosis factor- alpha), IL-6 
      (Interleukin 6), and IL-1beta have also attenuated in SAC treated animals. 
      Furthermore, the mRNA expression levels of COX2 (cyclooxygenase-2), MCP-1 
      (monocyte chemoattractant protein-1), RANTES (regulated upon activation, normal T 
      cell expressed and secreted), and eotaxin were reduced in SAC treated animals. 
      Treatment of rats with SAC significantly reduced inflammation and eosinophil 
      infiltration in the lungs. These results suggest that SAC exert protection in 
      neonatal asthmatic rats suffering from acute or chronic inflammation by inducing 
      anti-inflammatory and cell-protective responses.
CI  - (c) The Author(s) 2020.
FAU - Jiang, Li
AU  - Jiang L
AUID- ORCID: 0000-0001-9866-3950
AD  - Department of Pediatrics, The First Hospital of Lanzhou University, Lanzhou, 
      China. RINGGOLD: 117741
FAU - Li, Yuning
AU  - Li Y
AD  - Department of Pediatrics, The First Hospital of Lanzhou University, Lanzhou, 
      China. RINGGOLD: 117741
FAU - Wang, Fang
AU  - Wang F
AD  - Department of Pediatrics, The First Hospital of Lanzhou University, Lanzhou, 
      China. RINGGOLD: 117741
FAU - Zhang, Xindao
AU  - Zhang X
AD  - Department of Pediatrics, The First Hospital of Lanzhou University, Lanzhou, 
      China. RINGGOLD: 117741
FAU - Zhao, Ruiping
AU  - Zhao R
AD  - Department of Pediatrics, The First Hospital of Lanzhou University, Lanzhou, 
      China. RINGGOLD: 117741
LA  - eng
PT  - Journal Article
DEP - 20201224
PL  - United States
TA  - Dose Response
JT  - Dose-response : a publication of International Hormesis Society
JID - 101308899
PMC - PMC7768841
OTO - NOTNLM
OT  - S-allyl cysteine
OT  - inflammation
OT  - neonatal asthma
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2021/01/26 06:00
MHDA- 2021/01/26 06:01
PMCR- 2020/12/24
CRDT- 2021/01/25 05:38
PHST- 2020/09/21 00:00 [received]
PHST- 2020/11/16 00:00 [revised]
PHST- 2020/11/26 00:00 [accepted]
PHST- 2021/01/25 05:38 [entrez]
PHST- 2021/01/26 06:00 [pubmed]
PHST- 2021/01/26 06:01 [medline]
PHST- 2020/12/24 00:00 [pmc-release]
AID - 10.1177_1559325820982189 [pii]
AID - 10.1177/1559325820982189 [doi]
PST - epublish
SO  - Dose Response. 2020 Dec 24;18(4):1559325820982189. doi: 10.1177/1559325820982189. 
      eCollection 2020 Oct-Dec.