PMID- 33488627
OWN - NLM
STAT- MEDLINE
DCOM- 20210628
LR  - 20220716
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 11
DP  - 2020
TI  - Antigen-Presenting Cells in Food Tolerance and Allergy.
PG  - 616020
LID - 10.3389/fimmu.2020.616020 [doi]
LID - 616020
AB  - Food allergy now affects 6%-8% of children in the Western world; despite this, we 
      understand little about why certain people become sensitized to food allergens. 
      The dominant form of food allergy is mediated by food-specific immunoglobulin E 
      (IgE) antibodies, which can cause a variety of symptoms, including 
      life-threatening anaphylaxis. A central step in this immune response to food 
      antigens that differentiates tolerance from allergy is the initial priming of T 
      cells by antigen-presenting cells (APCs), primarily different types of dendritic 
      cells (DCs). DCs, along with monocyte and macrophage populations, dictate oral 
      tolerance versus allergy by shaping the T cell and subsequent B cell antibody 
      response. A growing body of literature has shed light on the conditions under 
      which antigen presentation occurs and how different types of T cell responses are 
      induced by different APCs. We will review APC subsets in the gut and discuss 
      mechanisms of APC-induced oral tolerance versus allergy to food identified using 
      mouse models and patient samples.
CI  - Copyright (c) 2021 Liu, Yin, Swaminathan and Eisenbarth.
FAU - Liu, Elise G
AU  - Liu EG
AD  - Department of Laboratory Medicine, Yale University School of Medicine, New Haven, 
      CT, United States.
AD  - Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 
      United States.
AD  - Section of Rheumatology, Allergy & Immunology, Yale University School of 
      Medicine, New Haven, CT, United States.
FAU - Yin, Xiangyun
AU  - Yin X
AD  - Department of Laboratory Medicine, Yale University School of Medicine, New Haven, 
      CT, United States.
AD  - Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 
      United States.
FAU - Swaminathan, Anush
AU  - Swaminathan A
AD  - Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 
      United States.
FAU - Eisenbarth, Stephanie C
AU  - Eisenbarth SC
AD  - Department of Laboratory Medicine, Yale University School of Medicine, New Haven, 
      CT, United States.
AD  - Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 
      United States.
AD  - Section of Rheumatology, Allergy & Immunology, Yale University School of 
      Medicine, New Haven, CT, United States.
LA  - eng
GR  - T32 GM136651/GM/NIGMS NIH HHS/United States
GR  - T32 AR007107/AR/NIAMS NIH HHS/United States
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
GR  - R01 AI136942/AI/NIAID NIH HHS/United States
GR  - R56 AI155497/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210108
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Allergens)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - Antigen-Presenting Cells/*immunology
MH  - Food Hypersensitivity/*immunology
MH  - Humans
MH  - Immune Tolerance/*immunology
MH  - Intestines/*immunology
PMC - PMC7821622
OTO - NOTNLM
OT  - Peyer's patches
OT  - dendritic cells
OT  - food allergy
OT  - gut
OT  - macrophages
OT  - mesenteric lymph node
OT  - monocytes
OT  - oral tolerance
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/01/26 06:00
MHDA- 2021/06/29 06:00
PMCR- 2020/01/01
CRDT- 2021/01/25 05:39
PHST- 2020/10/10 00:00 [received]
PHST- 2020/11/20 00:00 [accepted]
PHST- 2021/01/25 05:39 [entrez]
PHST- 2021/01/26 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2020.616020 [doi]
PST - epublish
SO  - Front Immunol. 2021 Jan 8;11:616020. doi: 10.3389/fimmu.2020.616020. eCollection 
      2020.