PMID- 33488805
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210126
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 21
IP  - 3
DP  - 2021 Mar
TI  - Influence of esophageal morphology on the clinical efficacy of peroral endoscopic 
      myotomy in treating advanced achalasia cardia.
PG  - 196
LID - 10.3892/etm.2021.9629 [doi]
LID - 196
AB  - Peroral endoscopic myotomy (POEM) is the first-line treatment of achalasia cardia 
      (AC). However, the efficacy of POEM in treating patients with advanced AC remains 
      to be determined. The aim of the present study was to evaluate the feasibility 
      and clinical outcome of POEM in treating patients with advanced AC involving 
      different esophageal morphologies. The study was a single-center, retrospective 
      analysis of patients suffering from advanced AC. The primary endpoint was the 
      Eckardt score at the follow-up examination. Secondary endpoints were 
      procedural-related details, including the operation time and length of myotomy, 
      adverse events (AEs) and hospital stay, as well as post-procedural 
      gastroesophageal reflux disease. The technical success rate was 100%. All 50 
      patients enrolled underwent successful endoscopic myotomy (conventional POEM, 
      n=20; modified POEM, n=30). AEs were observed in 10 patients. During a 6- to 
      50-month follow-up period, 41 patients achieved clinical success as evidenced by 
      a decrease in the Eckardt score. Only 3 of 6 patients with a sigmoid-shaped 
      megaesophagus obtained symptomatic relief. Symptomatic reflux occurred in 13 of 
      46 patients who completed their follow-up. In conclusion, POEM is safe, feasible 
      and effective in treating advanced AC. Patients with a sigmoid-shaped 
      megaesophagus are less likely to report palliation of symptoms.
CI  - Copyright: (c) Liu et al.
FAU - Liu, Dan
AU  - Liu D
AD  - Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, Henan 450052, P.R. China.
FAU - Liu, Yue-Yuan
AU  - Liu YY
AD  - Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, Henan 450052, P.R. China.
FAU - Chen, Jia-Xin
AU  - Chen JX
AD  - Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, Henan 450052, P.R. China.
FAU - Song, Lei
AU  - Song L
AD  - Department of Gastroenterology, The Hospital of Hei Long Jiang Province, Harbin, 
      Heilongjiang 150036, P.R. China.
FAU - Zhou, Yang-Yang
AU  - Zhou YY
AD  - Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, Henan 450052, P.R. China.
FAU - Ullah, Saif
AU  - Ullah S
AD  - Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, Henan 450052, P.R. China.
FAU - Zhao, Li-Xia
AU  - Zhao LX
AD  - Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, Henan 450052, P.R. China.
AD  - Department of Digestive Endoscopy Center, The First Affiliated Hospital of 
      Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
FAU - Hai, Bin
AU  - Hai B
AD  - Department of Digestive Endoscopy Center, The First Affiliated Hospital of 
      Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
FAU - Zheng, Qing-Fen
AU  - Zheng QF
AD  - Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, Henan 450052, P.R. China.
FAU - Li, Dong-Ying
AU  - Li DY
AD  - Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, Henan 450052, P.R. China.
FAU - He, De-Zhi
AU  - He DZ
AD  - Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, Henan 450052, P.R. China.
FAU - Liu, Bing-Rong
AU  - Liu BR
AD  - Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, Henan 450052, P.R. China.
AD  - State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou 
      University, Zhengzhou, Henan 450052, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20210108
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC7812585
OTO - NOTNLM
OT  - advanced achalasia cardia
OT  - esophageal morphology
OT  - peroral endoscopic myotomy
EDAT- 2021/01/26 06:00
MHDA- 2021/01/26 06:01
PMCR- 2021/01/08
CRDT- 2021/01/25 05:39
PHST- 2020/05/07 00:00 [received]
PHST- 2020/11/26 00:00 [accepted]
PHST- 2021/01/25 05:39 [entrez]
PHST- 2021/01/26 06:00 [pubmed]
PHST- 2021/01/26 06:01 [medline]
PHST- 2021/01/08 00:00 [pmc-release]
AID - ETM-0-0-09629 [pii]
AID - 10.3892/etm.2021.9629 [doi]
PST - ppublish
SO  - Exp Ther Med. 2021 Mar;21(3):196. doi: 10.3892/etm.2021.9629. Epub 2021 Jan 8.