PMID- 33489496
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230919
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 12
IP  - 12
DP  - 2020 Dec 14
TI  - A Case of Alpha-1 Antitrypsin Deficiency and Organizing Pneumonia.
PG  - e12078
LID - 10.7759/cureus.12078 [doi]
LID - e12078
AB  - Alpha-1 antitrypsin deficiency (AATD) is an autosomal dominant genetic disorder 
      that presents with pulmonary complications and is most commonly manifested by 
      panacinar emphysema and chronic obstructive pulmonary disease. A 49-year-old 
      Caucasian female with a history of AATD and chronic tobacco use was referred to 
      both infectious disease and thoracic surgery clinics with worsening cough and 
      chronic intermittent hemoptysis for the evaluation of possible superimposed 
      infection or malignancy. She had previously been treated with multiple 
      antibiotics and Prolastin-CO (alpha-1-proteinase inhibitor). Initial CT of the 
      chest showed known chronic bronchiectasis, severe lower lung emphysema, and 
      right-sided lower lobe pulmonary masses. CT-guided biopsy of one mass showed 
      nonspecific inflammation, negative cultures, and negative cytology. Subsequent 
      follow-up with chest CT scans showed a decreasing size of right-sided pulmonary 
      masses and new left-sided nodule formation, which later stabilized in growth. 
      Based on symptoms and radiological and pathological findings, a diagnosis of 
      organizing pneumonia was made. We present an unusual case of bilateral pulmonary 
      masses mimicking infection and malignancy later found to be most consistent with 
      an organizing pneumonia in a patient with underlying AATD.
CI  - Copyright (c) 2020, Renduchintala et al.
FAU - Renduchintala, Kavita
AU  - Renduchintala K
AD  - Internal and Hospital Medicine, Moffitt Cancer Center, Tampa, USA.
FAU - Pabbathi, Smitha
AU  - Pabbathi S
AD  - Internal Medicine, Moffitt Cancer Center, Tampa, USA.
FAU - Nanjappa, Sowmya
AU  - Nanjappa S
AD  - Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, USA.
FAU - Ramsakal, Asha
AU  - Ramsakal A
AD  - Internal Medicine, Moffitt Cancer Center, Tampa, USA.
FAU - Greene, John
AU  - Greene J
AD  - Internal Medicine, Moffitt Cancer Center, Tampa, USA.
LA  - eng
PT  - Case Reports
DEP - 20201214
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC7805524
OTO - NOTNLM
OT  - alpha 1 antitrypsin deficiency
OT  - organizing pneumonia
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/01/26 06:00
MHDA- 2021/01/26 06:01
PMCR- 2020/12/14
CRDT- 2021/01/25 05:42
PHST- 2021/01/25 05:42 [entrez]
PHST- 2021/01/26 06:00 [pubmed]
PHST- 2021/01/26 06:01 [medline]
PHST- 2020/12/14 00:00 [pmc-release]
AID - 10.7759/cureus.12078 [doi]
PST - epublish
SO  - Cureus. 2020 Dec 14;12(12):e12078. doi: 10.7759/cureus.12078.