PMID- 33489777
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231110
IS  - 2214-7500 (Electronic)
IS  - 2214-7500 (Linking)
VI  - 8
DP  - 2021
TI  - Hepatoprotective, antioxidant and, anti-inflammatory potentials of gallic acid in 
      carbon tetrachloride-induced hepatic damage in Wistar rats.
PG  - 177-185
LID - 10.1016/j.toxrep.2021.01.001 [doi]
AB  - Gallic acid (GA) is a known phenolic compound with anti-inflammatory, 
      antioxidant, and anti-cancer activities. The objective of this research is to 
      evaluate the preventive role of GA against carbon tetrachloride (CCl(4)) induced 
      liver fibrosis. Thirty-five (35) male Wistar rats were used in this study and 
      were equally distributed into five groups (7 rats each). All groups were 
      acclimatized for a week, Group I (control) rats were administered distilled water 
      only. Group II rats were induced with a single dose of CCl(4) (1.25 mL/kg in 
      olive oil (1:1); IP) to cause hepatic damage, while Groups III, IV, and V, rats 
      were intoxicated with CCl(4). After 24 h the rats in groups III, IV, and V were 
      given 50 mg/kg of silymarin, 50 mg/kg of GA, and 100 mg/kg of GA daily for one 
      week respectively. Rats were sacrificed and fasting blood was estimated for 
      biochemical analysis while the liver was excised for molecular studies. Results 
      from this study revealed that GA significantly decreases serum hepatic enzymes, 
      down-regulate the expression of pro-inflammatory cytokines, interleukin 1 beta 
      (IL-1B), interleukin 6 (IL-6), cyclooxygenase 2 (COX 2), and tumor necrosis 
      factor-alpha (TNF alpha), and up-regulate antioxidant gene expression (superoxide 
      dismutase and catalase). The use of gallic acid as natural antioxidants can be 
      promising in ameliorating liver diseases.
CI  - (c) 2021 The Authors. Published by Elsevier B.V.
FAU - Ojeaburu, S I
AU  - Ojeaburu SI
AD  - Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin 
      City, Nigeria.
FAU - Oriakhi, K
AU  - Oriakhi K
AD  - Department of Medical Biochemistry, School of Basic Medical Sciences, University 
      of Benin, Benin City, Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20210108
PL  - Ireland
TA  - Toxicol Rep
JT  - Toxicology reports
JID - 101630272
PMC - PMC7806503
OTO - NOTNLM
OT  - ALB, albumin
OT  - ALP, alkaline phosphatase
OT  - ALT, alanine transaminase
OT  - ARE, antioxidant response element
OT  - AST, aspartate transaminase
OT  - Anti-inflammatory
OT  - Antioxidant
OT  - CAT, catalase
OT  - CCl4, carbon tetrachloride
OT  - COX2, cyclooxygenase 2
OT  - Cytokines
OT  - DGA, dodecylgallate
OT  - GA, gallic acid
OT  - GAPDH, glyceraldehydes3-phosphate dehydrogenase
OT  - GGT, gamma-glutamyl transpeptidase
OT  - GSH, glutathione
OT  - Gallic acid
OT  - IL-1beta, interleukin 1beta
OT  - IL-6, interleukin 6
OT  - Keap1, kelch-like ECH-associated protein 1
OT  - Liver disease
OT  - MDA, maloniadehyde
OT  - NF-kappaB, nuclear factor kappa light chain enhancer of activated B cells
OT  - Nrf 2, nuclear factor erythroid- derived 2 like 2 genes
OT  - PBS, phosphate-buffered saline
OT  - RNA, ribonucleic acid
OT  - RT-PCR, reverse transcription-polymerase chain reaction
OT  - SOD, superoxide dismutase
OT  - SYBR, green fluorescent DNA Stain
OT  - TB, total bilirubin
OT  - TNF alpha, tumor necrosis factor-alpha
OT  - TP, total protein
OT  - cDNA, complementary deoxyribonucleic acid
OT  - iNOS, inducible nitric oxide synthase
OT  - qPCR, quantitative polymerase chain reaction
COIS- The authors declare no conflict of interest
EDAT- 2021/01/26 06:00
MHDA- 2021/01/26 06:01
PMCR- 2021/01/08
CRDT- 2021/01/25 05:43
PHST- 2020/10/01 00:00 [received]
PHST- 2020/12/30 00:00 [revised]
PHST- 2021/01/04 00:00 [accepted]
PHST- 2021/01/25 05:43 [entrez]
PHST- 2021/01/26 06:00 [pubmed]
PHST- 2021/01/26 06:01 [medline]
PHST- 2021/01/08 00:00 [pmc-release]
AID - S2214-7500(21)00001-9 [pii]
AID - 10.1016/j.toxrep.2021.01.001 [doi]
PST - epublish
SO  - Toxicol Rep. 2021 Jan 8;8:177-185. doi: 10.1016/j.toxrep.2021.01.001. eCollection 
      2021.