PMID- 33490113
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220420
IS  - 2296-9381 (Print)
IS  - 2296-9357 (Electronic)
IS  - 2296-9357 (Linking)
VI  - 6
IP  - 5
DP  - 2020 Sep
TI  - Advances in Pathogenesis of Idiopathic Membranous Nephropathy.
PG  - 330-345
LID - 10.1159/000507704 [doi]
AB  - BACKGROUND: Membranous nephropathy (MN), a major cause of nephrotic syndrome, has 
      attracted people's attention in recent years for its growing prevalence. It is 
      the second or third leading cause of ESRD in patients with primary 
      glomerulonephritis and is the leading glomerulopathy that recurs after kidney 
      transplantation. SUMMARY: MN can be classified as idiopathic membranous 
      nephropathy (IMN) and secondary MN. The discovery of the M-type phospholipase A2 
      receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) provides 
      the new diagnostic methods and treatment strategies for IMN on the molecular 
      level. The study on single nucleotide polymorphism of IMN genes, such as the 
      single M-type phospholipase A2 receptor 1 (PLA2R1) gene and human leukocyte 
      antigen (HLA) gene, explains the pathogenesis of the disease from the perspective 
      of genetics and conforms to the trend of the era of precision medicine. KEY 
      MESSAGES: This review focuses on advances in the pathogenesis of IMN, including 
      molecular and genetic pathogenesis, as well as discussing the diagnostic and 
      treatment guiding value brought by these new discoveries.
CI  - Copyright (c) 2020 by S. Karger AG, Basel.
FAU - Xu, Zhifeng
AU  - Xu Z
AD  - Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Chen, Lu
AU  - Chen L
AD  - Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Xiang, Huiling
AU  - Xiang H
AD  - Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Zhang, Chun
AU  - Zhang C
AD  - Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Xiong, Jing
AU  - Xiong J
AD  - Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200602
PL  - Switzerland
TA  - Kidney Dis (Basel)
JT  - Kidney diseases (Basel, Switzerland)
JID - 101658365
PMC - PMC7745661
OTO - NOTNLM
OT  - Membranous nephropathy
OT  - Phospholipase A2 receptor
OT  - Podocyte autoantigen
OT  - Single nucleotide polymorphisms
OT  - Thrombospondin type-1 domain-containing 7A
COIS- The authors have no conflicts of interest to declare.
EDAT- 2021/01/26 06:00
MHDA- 2021/01/26 06:01
PMCR- 2021/09/01
CRDT- 2021/01/25 05:44
PHST- 2019/10/02 00:00 [received]
PHST- 2020/04/02 00:00 [accepted]
PHST- 2021/01/25 05:44 [entrez]
PHST- 2021/01/26 06:00 [pubmed]
PHST- 2021/01/26 06:01 [medline]
PHST- 2021/09/01 00:00 [pmc-release]
AID - kdd-0006-0330 [pii]
AID - 10.1159/000507704 [doi]
PST - ppublish
SO  - Kidney Dis (Basel). 2020 Sep;6(5):330-345. doi: 10.1159/000507704. Epub 2020 Jun 
      2.