PMID- 33491494
OWN - NLM
STAT- MEDLINE
DCOM- 20211130
LR  - 20220421
IS  - 1473-0766 (Electronic)
IS  - 0951-3590 (Linking)
VI  - 37
IP  - 4
DP  - 2021 Apr
TI  - Human umbilical cord mesenchymal stem cells (hUCMSCs) promotes the recovery of 
      ovarian function in a rat model of premature ovarian failure (POF).
PG  - 353-357
LID - 10.1080/09513590.2021.1878133 [doi]
AB  - AIMS: Our study was to evaluate the benefits of human umbilical cord mesenchymal 
      stem cells (hUCMSCs) for the prevention of premature ovarian failure (POF) in a 
      rat model. MATERIALS AND METHODS: 80 female SD rats aged between 6 and 8 weeks 
      were randomly divided into 4 groups A, B, C and D. Rats in group A is normal 
      control group; group B, C and D received zona pellucida glycoprotein 3 (pZP3) 
      administration to induce POF model. Among these, group B is model control group; 
      group C received PBS injection in ovaries and group D received hUCMSCs injection 
      in ovaries, all injections were performed after modeling on the same day. Estrus 
      cycle; serum hormone level of luteinizing hormone (LH) and follicle-stimulating 
      hormone (FSH) and amount of ovarian follicles were detected 20 days after 
      treatment. RESULTS: We successfully injected hUCMSCs in the ovary tissue of a POF 
      rat. The estrus cycle and hormone expression of the rats in group D tends to be 
      normal. Histological studies indicated that hUCMSCs transplantation increased the 
      amount of ovarian follicles. CONCLUSIONS: This study shows that hUCMSCs may have 
      a preventive effect on POF rats.
FAU - Zhang, Xunyi
AU  - Zhang X
AD  - Reproductive Medicine Center, Tongji Hospital, Tongji University School of 
      Medicine, Shanghai, China.
FAU - Zhang, Lina
AU  - Zhang L
AD  - Reproductive Medicine Center, Tongji Hospital, Tongji University School of 
      Medicine, Shanghai, China.
FAU - Li, Ying
AU  - Li Y
AD  - Reproductive Medicine Center, Tongji Hospital, Tongji University School of 
      Medicine, Shanghai, China.
FAU - Yin, Zhe
AU  - Yin Z
AD  - Reproductive Medicine Center, Tongji Hospital, Tongji University School of 
      Medicine, Shanghai, China.
FAU - Feng, Yun
AU  - Feng Y
AD  - Reproductive Medicine Center, Tongji Hospital, Tongji University School of 
      Medicine, Shanghai, China.
FAU - Ji, Yazhong
AU  - Ji Y
AD  - Reproductive Medicine Center, Tongji Hospital, Tongji University School of 
      Medicine, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20210125
PL  - England
TA  - Gynecol Endocrinol
JT  - Gynecological endocrinology : the official journal of the International Society 
      of Gynecological Endocrinology
JID - 8807913
RN  - 0 (Zona Pellucida Glycoproteins)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Estrous Cycle/drug effects/*metabolism/physiology
MH  - Female
MH  - Humans
MH  - *Mesenchymal Stem Cell Transplantation
MH  - *Mesenchymal Stem Cells
MH  - Ovary/drug effects/*metabolism/physiology
MH  - Primary Ovarian Insufficiency/chemically induced/*metabolism/physiopathology
MH  - Rats
MH  - Recovery of Function
MH  - Umbilical Cord/cytology
MH  - Zona Pellucida Glycoproteins/toxicity
OTO - NOTNLM
OT  - Premature ovarian failure (POF)
OT  - animal model
OT  - stem cell transplantation
OT  - umbilical cord mesenchymal stem cells (UCMSCs)
EDAT- 2021/01/26 06:00
MHDA- 2021/12/01 06:00
CRDT- 2021/01/25 08:40
PHST- 2021/01/26 06:00 [pubmed]
PHST- 2021/12/01 06:00 [medline]
PHST- 2021/01/25 08:40 [entrez]
AID - 10.1080/09513590.2021.1878133 [doi]
PST - ppublish
SO  - Gynecol Endocrinol. 2021 Apr;37(4):353-357. doi: 10.1080/09513590.2021.1878133. 
      Epub 2021 Jan 25.