PMID- 33492183
OWN - NLM
STAT- MEDLINE
DCOM- 20220411
LR  - 20220707
IS  - 1532-4303 (Electronic)
IS  - 0277-0903 (Linking)
VI  - 59
IP  - 4
DP  - 2022 Apr
TI  - IL-35 and IL-37 are negatively correlated with high IgE production among children 
      with asthma in Saudi Arabia.
PG  - 655-662
LID - 10.1080/02770903.2021.1878533 [doi]
AB  - BACKGROUND: Asthma is one of the most prevalent inflammatory disorders among 
      children in Saudi Arabia. OBJECTIVE: This study aimed to determine the 
      correlation between the serum levels of vitamin D, immunoglobulin E (IgE), and 
      cytokine (interferon-gamma (IFN-gamma), interleukin (IL)-1beta, IL-4, IL-6, IL-10, 
      IL-13, IL-35, and IL-37) in relation to the severity of disease in patients with 
      asthma. METHODS: This case-control study was carried out at King Abdullah 
      Specialist Children's Hospital, Saudi Arabia, and included 48 patients with 
      asthma and 47 matched controls, aged 6-14 years. A validated questionnaire was 
      administered to the participants, after which each patient with asthma underwent 
      pulmonary function tests. The serum levels of vitamin D, IgE, IFN-gamma, IL-1beta, IL-4, 
      IL-6, IL-10, IL-13, IL-35, and IL-37 of each participant were also measured. 
      RESULTS: Patients with asthma demonstrated significantly higher IgE and cytokine 
      (IL-1beta, IL-4, IL-6, IL-10, IL-13, IL-35, and IL-37) levels compared to the 
      control group (p value < .001). The levels of IL-1beta, IL-4, IL-10, and IL-13 were 
      consistently positively correlated with the serum levels of IgE among patients 
      with asthma. However, the IgE levels in patients with asthma were consistently 
      negatively correlated with IL-35 and IL-37. CONCLUSIONS: We found significantly 
      higher levels of eosinophils, IgE, IL-1beta, IL-4, IL-6, IL-10, IL-13, IL-35, and 
      IL-37 in patients with asthma compared to the controls, but no relationship 
      between vitamin D and asthma.
FAU - Abushouk, Amir
AU  - Abushouk A
AD  - Department of Basic Medical Sciences, College of Medicine, King Saud Bin 
      Abdulaziz University for Health Sciences (KSAU-HS), Jeddah, Kingdom of Saudi 
      Arabia.
AD  - King Abdullah International Medical Research Centre (KAIMRC), Jeddah, Kingdom of 
      Saudi Arabia.
FAU - Alkhalaf, Hamad
AU  - Alkhalaf H
AD  - Department of Pediatrics, King Abdulaziz Medical City, Ministry of National Guard 
      Health Affairs, Riyadh, Kingdom of Saudi Arabia.
AD  - King Abdullah International Medical Research Center (KAIMRC), Riyadh, Kingdom of 
      Saudi Arabia.
AD  - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences 
      (KSAU-HS), Riyadh, Kingdom of Saudi Arabia.
FAU - Aldamegh, Moniraa
AU  - Aldamegh M
AD  - King Abdullah International Medical Research Center (KAIMRC), Riyadh, Kingdom of 
      Saudi Arabia.
AD  - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences 
      (KSAU-HS), Riyadh, Kingdom of Saudi Arabia.
FAU - Bin Shigair, Shehana
AU  - Bin Shigair S
AD  - King Abdullah International Medical Research Center (KAIMRC), Riyadh, Kingdom of 
      Saudi Arabia.
AD  - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences 
      (KSAU-HS), Riyadh, Kingdom of Saudi Arabia.
FAU - Mahabbat, Nadin
AU  - Mahabbat N
AD  - King Abdullah International Medical Research Center (KAIMRC), Riyadh, Kingdom of 
      Saudi Arabia.
AD  - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences 
      (KSAU-HS), Riyadh, Kingdom of Saudi Arabia.
FAU - Hakami, Maumonah
AU  - Hakami M
AD  - King Abdullah International Medical Research Center (KAIMRC), Riyadh, Kingdom of 
      Saudi Arabia.
AD  - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences 
      (KSAU-HS), Riyadh, Kingdom of Saudi Arabia.
FAU - Abu-Jaffal, Ahmad Saleh
AU  - Abu-Jaffal AS
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      King Saud bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi 
      Arabia.
FAU - Nasr, Amre
AU  - Nasr A
AD  - Department of Basic Medical Sciences, College of Medicine, King Saud Bin 
      Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Kingdom of Saudi 
      Arabia.
AD  - Department of Immunology, King Abdullah International Medical Research Center 
      (KAIMRC), Riyadh, Kingdom of Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210213
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 0 (Cytokines)
RN  - 0 (IL37 protein, human)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-13)
RN  - 0 (Interleukin-6)
RN  - 130068-27-8 (Interleukin-10)
RN  - 1406-16-2 (Vitamin D)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - *Asthma/epidemiology
MH  - Case-Control Studies
MH  - Child
MH  - Cytokines
MH  - Humans
MH  - *Immunoglobulin E
MH  - Interferon-gamma
MH  - *Interleukin-1/blood
MH  - Interleukin-10
MH  - Interleukin-13
MH  - Interleukin-4
MH  - Interleukin-6
MH  - Saudi Arabia/epidemiology
MH  - Vitamin D
OTO - NOTNLM
OT  - Asthma
OT  - IgE
OT  - KSA
OT  - cytokines
OT  - vitamin D
EDAT- 2021/01/26 06:00
MHDA- 2022/04/12 06:00
CRDT- 2021/01/25 12:12
PHST- 2021/01/26 06:00 [pubmed]
PHST- 2022/04/12 06:00 [medline]
PHST- 2021/01/25 12:12 [entrez]
AID - 10.1080/02770903.2021.1878533 [doi]
PST - ppublish
SO  - J Asthma. 2022 Apr;59(4):655-662. doi: 10.1080/02770903.2021.1878533. Epub 2021 
      Feb 13.