PMID- 33492205
OWN - NLM
STAT- MEDLINE
DCOM- 20220309
LR  - 20221207
IS  - 1477-0377 (Electronic)
IS  - 1358-863X (Print)
IS  - 1358-863X (Linking)
VI  - 26
IP  - 2
DP  - 2021 Apr
TI  - Association of peripheral artery disease and chronic limb-threatening ischemia 
      with socioeconomic deprivation in people with diabetes: A population data-linkage 
      and geospatial analysis.
PG  - 147-154
LID - 10.1177/1358863X20981132 [doi]
AB  - The association between the prevalence and geographical distribution of 
      peripheral artery disease (PAD) and chronic limb-threatening ischemia (CLTI) in 
      patients with diabetes in the context of socioeconomic deprivation is not well 
      understood. We undertook a retrospective cohort study of 76,307 people with 
      diabetes admitted as a hospital inpatient in a large Scottish health 
      administrative area. Utilising linked health records, we identified diagnoses of 
      PAD and/or CLTI and their distribution using small area cartography techniques 
      according to multiple deprivation maps. Spatial autocorrelation techniques were 
      applied to examine PAD and CLTI patterning. Association between crude inpatient 
      prevalence-adjusted outcome rates and exposure to social deprivation were 
      determined. We found crude prevalence-adjusted rates of 8.05% for PAD and 1.10% 
      for CLTI with a five- to sevenfold difference from the least to most deprived 
      regions. Statistically significant hot spots were found for PAD (p < 0.001) and 
      CLTI (p < 0.001) in the most deprived areas, and cold spots for PAD (p < 0.001) 
      but not CLTI (p = 0.72) in the least deprived areas. Major health disparities in 
      PAD/CLTI diagnoses in people with diabetes is driven by socioeconomic 
      deprivation.
FAU - Hurst, Joanne E
AU  - Hurst JE
AUID- ORCID: 0000-0003-1175-1216
AD  - School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, 
      Scotland, UK.
FAU - Tehan, Peta Ellen
AU  - Tehan PE
AUID- ORCID: 0000-0002-0014-3023
AD  - School of Health Sciences, Faculty of Health & Medicine, University of Newcastle, 
      Ourimbah, NSW, Australia.
FAU - Hussey, Keith
AU  - Hussey K
AD  - Department of Vascular Surgery, Queen Elizabeth University Hospital, Glasgow, 
      Scotland, UK.
FAU - Woodburn, James
AU  - Woodburn J
AD  - School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, 
      Scotland, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210125
PL  - England
TA  - Vasc Med
JT  - Vascular medicine (London, England)
JID - 9610930
SB  - IM
MH  - Amputation, Surgical
MH  - Chronic Disease
MH  - Chronic Limb-Threatening Ischemia
MH  - *Diabetes Mellitus/diagnosis/epidemiology
MH  - Humans
MH  - Ischemia
MH  - Limb Salvage
MH  - *Peripheral Arterial Disease/diagnosis/epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Socioeconomic Factors
MH  - Treatment Outcome
PMC - PMC8033436
OTO - NOTNLM
OT  - chronic limb-threatening ischemia (CLTI)
OT  - diabetes
OT  - geospatial mapping
OT  - health disparities
OT  - peripheral artery disease (PAD)
OT  - spatial clustering
COIS- Declaration of conflicting interests: The authors declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2021/01/26 06:00
MHDA- 2022/03/11 06:00
PMCR- 2021/04/09
CRDT- 2021/01/25 12:12
PHST- 2021/01/26 06:00 [pubmed]
PHST- 2022/03/11 06:00 [medline]
PHST- 2021/01/25 12:12 [entrez]
PHST- 2021/04/09 00:00 [pmc-release]
AID - 10.1177_1358863X20981132 [pii]
AID - 10.1177/1358863X20981132 [doi]
PST - ppublish
SO  - Vasc Med. 2021 Apr;26(2):147-154. doi: 10.1177/1358863X20981132. Epub 2021 Jan 
      25.