PMID- 33493724
OWN - NLM
STAT- MEDLINE
DCOM- 20210211
LR  - 20210211
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 211
DP  - 2021 Mar 15
TI  - Association of long-term exposure to ambient air pollution with the incidence of 
      sleep disorders: A cohort study in China.
PG  - 111956
LID - S0147-6513(21)00067-1 [pii]
LID - 10.1016/j.ecoenv.2021.111956 [doi]
AB  - BACKGROUND: Sleep disorders have been verified to be associated with adverse 
      health outcomes. Recent studies have linked ambient air pollution to sleep 
      disorders. However, evidence with large sample size and especially prospective 
      studies is very limited. METHODS: We used data from a prospective cohort study 
      established from 2015 to 2018 in Ningbo, China. Participants were followed-up 
      after baseline survey through linkage to the regional Health Information System 
      (HIS). Sleep disorders were defined based on International Classification of 
      Disease 10 (ICD-10). Spatial-temporal land-use regression (LUR) models were used 
      to estimate the annual exposure to particulate matter with diameter </= 2.5 microm 
      (PM(2.5)), </= 10 microm (PM(10)) and nitrogen dioxides (NO(2)). The associations 
      between long-term exposure to air pollutants and prevalence of sleep disorders 
      were examined using logistic regression models, and Cox regression models for the 
      effects of air pollution on the incidence of sleep disorders. A generalized 
      weighted quantile sum (gWQS) regression was used in the multipollutant analysis. 
      RESULTS: A total of 38,775 participants were included in the final analysis. 
      Based on baseline data, we observed significant positive associations between air 
      pollution exposure and increased odds of prevalent sleep disorders (Odds Ratio 
      (OR)= 1.48, 95% confidence interval (CI): 1.41-1.55 for PM(2.5); 
      OR= 1.47,95%CI:1.38-1.57 for PM(10); OR= 1.38, 95%CI:1.31-1.46 for NO(2)). In the 
      longitudinal analysis, hazard ratios for incident sleep disorders associated with 
      per interquartile range (IQR) increase in PM(2.5), PM(10) and NO(2) were 1.14 
      (1.03, 1.25), 1.13 (1.01, 1.27) and 1.13 (1.04, 1.23), respectively. A gWQS 
      regression analysis showed significant association between air pollution mixture 
      and incident sleep disorders (OR=1.11, 95%CI: 1.03-1.20). CONCLUSIONS: Long-term 
      exposure to PM(2.5), PM(10) and NO(2) were associated with increased risk of 
      sleep disorders in a Chinese population. Our findings could provide evidence for 
      a more general role in the adverse health impact of air pollution.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Yu, Zhebin
AU  - Yu Z
AD  - Department of Epidemiology and Biostatistics, Zhejiang University School of 
      Medicine, Hangzhou, Zhejiang, China.
FAU - Wei, Fang
AU  - Wei F
AD  - Department of Epidemiology and Biostatistics, Zhejiang University School of 
      Medicine, Hangzhou, Zhejiang, China.
FAU - Wu, Mengyin
AU  - Wu M
AD  - Department of Epidemiology and Biostatistics, Zhejiang University School of 
      Medicine, Hangzhou, Zhejiang, China.
FAU - Lin, Hongbo
AU  - Lin H
AD  - The Center for Disease Control and Prevention of Yinzhou District, Ningbo, 
      Zhejiang, China.
FAU - Shui, Liming
AU  - Shui L
AD  - Health Commission of Ningbo, Zhejiang, China.
FAU - Jin, Mingjuan
AU  - Jin M
AD  - Department of Epidemiology and Biostatistics, Zhejiang University School of 
      Medicine, Hangzhou, Zhejiang, China; Cancer Institute of the Second Affiliated 
      Hospital, Zhejiang University School of Medicine, Zhejiang, China.
FAU - Wang, Jianbing
AU  - Wang J
AD  - Department of Epidemiology and Biostatistics, Zhejiang University School of 
      Medicine, Hangzhou, Zhejiang, China; National Clinical Research Center for Child 
      Health of the Children's Hospital, Zhejiang University School of Medicine, 
      Zhejiang, China. Electronic address: wangjianbing@zju.edu.cn.
FAU - Tang, Mengling
AU  - Tang M
AD  - Department of Epidemiology and Biostatistics, Zhejiang University School of 
      Medicine, Hangzhou, Zhejiang, China. Electronic address: tangml@zju.edu.cn.
FAU - Chen, Kun
AU  - Chen K
AD  - Department of Epidemiology and Biostatistics, Zhejiang University School of 
      Medicine, Hangzhou, Zhejiang, China; Cancer Institute of the Second Affiliated 
      Hospital, Zhejiang University School of Medicine, Zhejiang, China. Electronic 
      address: ck@zju.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210125
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Air Pollutants)
RN  - 0 (Particulate Matter)
RN  - S7G510RUBH (Nitrogen Dioxide)
SB  - IM
MH  - Adult
MH  - Air Pollutants/analysis
MH  - Air Pollution/analysis/*statistics & numerical data
MH  - China/epidemiology
MH  - Cohort Studies
MH  - Environmental Exposure/analysis/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Nitrogen Dioxide/analysis
MH  - Odds Ratio
MH  - Particulate Matter/analysis
MH  - Prevalence
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Sleep Wake Disorders/*epidemiology
OTO - NOTNLM
OT  - Air pollution
OT  - Cohort study
OT  - Nitrogen dioxide
OT  - Particulate matter
OT  - Sleep disorders
EDAT- 2021/01/26 06:00
MHDA- 2021/02/12 06:00
CRDT- 2021/01/25 20:12
PHST- 2020/09/23 00:00 [received]
PHST- 2021/01/09 00:00 [revised]
PHST- 2021/01/14 00:00 [accepted]
PHST- 2021/01/26 06:00 [pubmed]
PHST- 2021/02/12 06:00 [medline]
PHST- 2021/01/25 20:12 [entrez]
AID - S0147-6513(21)00067-1 [pii]
AID - 10.1016/j.ecoenv.2021.111956 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2021 Mar 15;211:111956. doi: 
      10.1016/j.ecoenv.2021.111956. Epub 2021 Jan 25.