PMID- 33495162
OWN - NLM
STAT- MEDLINE
DCOM- 20220425
LR  - 20220531
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Linking)
VI  - 106
IP  - 5
DP  - 2022 May
TI  - Association of ambient air pollution with age-related macular degeneration and 
      retinal thickness in UK Biobank.
PG  - 705-711
LID - 10.1136/bjophthalmol-2020-316218 [doi]
AB  - AIM: To examine the associations of air pollution with both self-reported 
      age-related macular degeneration (AMD), and in vivo measures of retinal sublayer 
      thicknesses. METHODS: We included 115 954 UK Biobank participants aged 40-69 
      years old in this cross-sectional study. Ambient air pollution measures included 
      particulate matter, nitrogen dioxide (NO(2)) and nitrogen oxides (NO(x)). 
      Participants with self-reported ocular conditions, high refractive error (< -6 or 
      > +6 diopters) and poor spectral-domain optical coherence tomography (SD-OCT) 
      image were excluded. Self-reported AMD was used to identify overt disease. SD-OCT 
      imaging derived photoreceptor sublayer thickness and retinal pigment epithelium 
      (RPE) layer thickness were used as structural biomarkers of AMD for 52 602 
      participants. We examined the associations of ambient air pollution with 
      self-reported AMD and both photoreceptor sublayers and RPE layer thicknesses. 
      RESULTS: After adjusting for covariates, people who were exposed to higher fine 
      ambient particulate matter with an aerodynamic diameter <2.5 microm (PM(2.5), per IQR 
      increase) had higher odds of self-reported AMD (OR=1.08, p=0.036), thinner 
      photoreceptor synaptic region (beta=-0.16 microm, p=2.0 x 10(-5)), thicker photoreceptor 
      inner segment layer (beta=0.04 microm, p=0.001) and thinner RPE (beta=-0.13 microm, p=0.002). 
      Higher levels of PM(2.5) absorbance and NO(2) were associated with thicker 
      photoreceptor inner and outer segment layers, and a thinner RPE layer. Higher 
      levels of PM(10) (PM with an aerodynamic diameter <10 microm) was associated with 
      thicker photoreceptor outer segment and thinner RPE, while higher exposure to 
      NO(x) was associated with thinner photoreceptor synaptic region. CONCLUSION: 
      Greater exposure to PM(2.5) was associated with self-reported AMD, while PM(2.5), 
      PM(2.5) absorbance, PM(10), NO(2) and NO(x) were all associated with differences 
      in retinal layer thickness.
CI  - (c) Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and 
      permissions. Published by BMJ.
FAU - Chua, Sharon Y L
AU  - Chua SYL
AUID- ORCID: 0000-0002-2501-0948
AD  - UCL Institute of Ophthalmology, National Institute for Health Research Biomedical 
      Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute 
      of Ophthalmology, London, Greater London, UK.
FAU - Warwick, Alasdair
AU  - Warwick A
AD  - UCL Institute of Cardiovascular Science, University College London, London, UK.
FAU - Peto, Tunde
AU  - Peto T
AUID- ORCID: 0000-0001-6265-0381
AD  - School of Medicine, Dentistry and Biomedical Sciences, Queen's University 
      Belfast, Belfast, UK.
FAU - Balaskas, Konstantinos
AU  - Balaskas K
AD  - UCL Institute of Ophthalmology, National Institute for Health Research Biomedical 
      Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute 
      of Ophthalmology, London, Greater London, UK.
AD  - School of Biological Sciences, University of Manchester, Manchester, UK.
FAU - Moore, Anthony T
AU  - Moore AT
AD  - Department of Ophthalmology, University of California San Francisco, San 
      Francisco, California, USA.
FAU - Reisman, Charles
AU  - Reisman C
AD  - Topcon Healthcare Solutions Research & Development, Oakland, New Jersey, USA.
FAU - Desai, Parul
AU  - Desai P
AUID- ORCID: 0000-0002-7532-972X
AD  - Moorfields Eye Hospital, London, UK.
FAU - Lotery, Andrew J
AU  - Lotery AJ
AD  - Clinical and Experimental Sciences, Faculty of Medicine, University of 
      Southampton, Southampton, UK.
FAU - Dhillon, Baljean
AU  - Dhillon B
AD  - Centre for Clinical Brain Sciences, School of Clinical Sciences, University of 
      Edinburgh, Edinburgh, UK.
AD  - NHS Lothian Princess Alexandra Eye Pavilion, Edinburgh, UK.
FAU - Khaw, Peng T
AU  - Khaw PT
AD  - UCL Institute of Ophthalmology, National Institute for Health Research Biomedical 
      Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute 
      of Ophthalmology, London, Greater London, UK.
AD  - Moorfields Eye Hospital, London, UK.
FAU - Owen, Christopher G
AU  - Owen CG
AUID- ORCID: 0000-0003-1135-5977
AD  - Population Health Research Institute, St George's, University of London, London, 
      UK.
FAU - Khawaja, Anthony P
AU  - Khawaja AP
AD  - UCL Institute of Ophthalmology, National Institute for Health Research Biomedical 
      Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute 
      of Ophthalmology, London, Greater London, UK.
AD  - Moorfields Eye Hospital, London, UK.
FAU - Foster, Paul J
AU  - Foster PJ
AD  - UCL Institute of Ophthalmology, National Institute for Health Research Biomedical 
      Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute 
      of Ophthalmology, London, Greater London, UK p.foster@ucl.ac.uk.
AD  - Moorfields Eye Hospital, London, UK.
FAU - Patel, Praveen J
AU  - Patel PJ
AUID- ORCID: 0000-0001-8682-4067
AD  - UCL Institute of Ophthalmology, National Institute for Health Research Biomedical 
      Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute 
      of Ophthalmology, London, Greater London, UK.
AD  - Moorfields Eye Hospital, London, UK.
CN  - UK Biobank Eye and Vision Consortium
LA  - eng
GR  - MR/T040912/1/MRC_/Medical Research Council/United Kingdom
GR  - DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210125
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
RN  - 0 (Particulate Matter)
RN  - S7G510RUBH (Nitrogen Dioxide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Air Pollution/statistics & numerical data
MH  - Biological Specimen Banks
MH  - Cross-Sectional Studies
MH  - Humans
MH  - *Macular Degeneration/diagnosis/epidemiology/etiology
MH  - Middle Aged
MH  - Nitrogen Dioxide
MH  - Particulate Matter/adverse effects
MH  - Tomography, Optical Coherence/methods
MH  - United Kingdom/epidemiology
OTO - NOTNLM
OT  - epidemiology
OT  - imaging
OT  - macula
OT  - public health
OT  - retina
COIS- Competing interests: CR reports employment by Topcon Healthcare Solutions, Inc, 
      outside the submitted work. PJF reports personal fees from Allergan, Carl Zeiss, 
      Google/DeepMind and Santen, a grant from Alcon, outside the submitted work. PJP 
      reports grants from Topcon Inc, outside the submitted work.
EDAT- 2021/01/27 06:00
MHDA- 2022/04/26 06:00
CRDT- 2021/01/26 05:36
PHST- 2020/03/03 00:00 [received]
PHST- 2020/11/04 00:00 [revised]
PHST- 2020/12/07 00:00 [accepted]
PHST- 2021/01/27 06:00 [pubmed]
PHST- 2022/04/26 06:00 [medline]
PHST- 2021/01/26 05:36 [entrez]
AID - bjophthalmol-2020-316218 [pii]
AID - 10.1136/bjophthalmol-2020-316218 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2022 May;106(5):705-711. doi: 10.1136/bjophthalmol-2020-316218. 
      Epub 2021 Jan 25.