PMID- 33495435
OWN - NLM
STAT- MEDLINE
DCOM- 20211027
LR  - 20211027
IS  - 2329-0358 (Electronic)
IS  - 1425-9524 (Print)
IS  - 1425-9524 (Linking)
VI  - 26
DP  - 2021 Jan 26
TI  - Number of Bronchoscopic Interventions in Lung Transplant Recipients Correlates 
      with Respiratory Function Assessed by Pulmonary Function Tests.
PG  - e927025
LID - 10.12659/AOT.927025 [doi]
AB  - BACKGROUND Lung transplant recipients may suffer from airway stenosis (AS). The 
      aim of this study was to assess whether pulmonary function (as measured by 
      spirometry and a 6-minute walk test [6MWT]) in patients with AS treated 
      consistently with bronchoscopic interventions (BIs) was comparable to that in 
      their AS-free counterparts at the 1-year follow-up visit. MATERIAL AND METHODS 
      Fifty patients who underwent primary double-lung transplantation between January 
      2015 and March 2019 at a single center (23 who received BIs and 27 who did not) 
      were enrolled in this retrospective study. Graft function was assessed with 
      spirometry, based on forced expiratory volume (FEV(1)) and forced vital capacity 
      (FVC), both measured in liters (L) and percentages (%), and the Tiffeneau-Pinelli 
      index (FEV(1)/FVC), and a 6MWT and parameters such as oxygen saturation measured 
      before and after the test. RESULTS Patients in need of BIs had significantly 
      lower FEV(1)% compared with individuals who did not receive BIs during their first 
      post-transplant year. Airway obstruction was present in 22% of patients who did 
      not receive BIs and 65.23% of those who did receive the interventions. There were 
      statistically significant, strong, negative correlations pertaining to the number 
      of balloon BIs and 1-year FEV(1)% (rs=0.67) as well as the number of balloon BIs 
      and 1-year FEV(1)/FVC (rs=0.72). A statistically significant, strong, negative 
      correlation (rs=0.75) was found between the number of balloon bronchoplasty 
      treatments and oxygen saturation after the 6WMT. CONCLUSIONS Despite receiving 
      BIs, patients who experience bronchial stenosis may not obtain the expected 
      ventilatory improvement at their 1-year follow-up visit. Their AS may recur or 
      persist despite use of various procedures. Further study in that regard is 
      required.
FAU - Necki, Miroslaw
AU  - Necki M
AD  - Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, 
      Medical University of Silesia, Katowice, Poland.
AD  - Silesian Center for Heart Diseases, Zabrze, Poland.
FAU - Latos, Magdalena
AU  - Latos M
AD  - Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, 
      Medical University of Silesia, Katowice, Poland.
AD  - Silesian Center for Heart Diseases, Zabrze, Poland.
FAU - Urlik, Maciej
AU  - Urlik M
AD  - Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, 
      Medical University of Silesia, Katowice, Poland.
AD  - Silesian Center for Heart Diseases, Zabrze, Poland.
FAU - Antonczyk, Remigiusz
AU  - Antonczyk R
AD  - Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, 
      Medical University of Silesia, Katowice, Poland.
AD  - Silesian Center for Heart Diseases, Zabrze, Poland.
FAU - Gaweda, Martyna
AU  - Gaweda M
AD  - Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, 
      Medical University of Silesia, Katowice, Poland.
AD  - Silesian Center for Heart Diseases, Zabrze, Poland.
FAU - Pandel, Anastazja
AU  - Pandel A
AD  - Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, 
      Medical University of Silesia, Katowice, Poland.
AD  - Silesian Center for Heart Diseases, Zabrze, Poland.
FAU - Stacel, Tomasz
AU  - Stacel T
AD  - Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, 
      Medical University of Silesia, Katowice, Poland.
AD  - Silesian Center for Heart Diseases, Zabrze, Poland.
FAU - Przybylowski, Piotr
AU  - Przybylowski P
AD  - First Chair of General Surgery, Jagiellonian University , Crcaow, Poland.
FAU - Zembala, Marian
AU  - Zembala M
AD  - Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, 
      Medical University of Silesia, Katowice, Poland.
AD  - Silesian Center for Heart Diseases, Zabrze, Poland.
FAU - Ochman, Marek
AU  - Ochman M
AD  - Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, 
      Medical University of Silesia, Katowice, Poland.
AD  - Silesian Center for Heart Diseases, Zabrze, Poland.
LA  - eng
PT  - Journal Article
DEP - 20210126
PL  - United States
TA  - Ann Transplant
JT  - Annals of transplantation
JID - 9802544
SB  - IM
MH  - Adult
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - *Lung/physiology
MH  - *Lung Transplantation
MH  - Male
MH  - Middle Aged
MH  - Respiratory Function Tests
MH  - Retrospective Studies
MH  - *Transplant Recipients
PMC - PMC7847086
COIS- Conflicts of interest None.
EDAT- 2021/01/27 06:00
MHDA- 2021/10/28 06:00
PMCR- 2021/01/26
CRDT- 2021/01/26 05:41
PHST- 2021/01/26 05:41 [entrez]
PHST- 2021/01/27 06:00 [pubmed]
PHST- 2021/10/28 06:00 [medline]
PHST- 2021/01/26 00:00 [pmc-release]
AID - 927025 [pii]
AID - 10.12659/AOT.927025 [doi]
PST - epublish
SO  - Ann Transplant. 2021 Jan 26;26:e927025. doi: 10.12659/AOT.927025.