PMID- 33495502
OWN - NLM
STAT- MEDLINE
DCOM- 20210916
LR  - 20210916
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Jan 25
TI  - Association of serum lipopolysaccharide-binding protein level with sensitization 
      to food allergens in children.
PG  - 2143
LID - 10.1038/s41598-020-79241-x [doi]
LID - 2143
AB  - Lipopolysaccharide (LPS)-binding protein (LBP) is an acute-phase reactant that 
      mediates innate immune responses triggered by LPS. Recent studies indicated a 
      positive correlation of circulating LBP level with chronic low-grade 
      inflammation, a condition present in many non-communicable diseases. We 
      determined the association of serum LBP concentration with allergic sensitization 
      in a general pediatric population. Serum LBP was measured in a sample of children 
      (n = 356; mean age = 9.6 +/- 0.2 years) in this population-based cross-sectional 
      study. Skin prick tests (SPTs) were performed to assess allergic sensitization to 
      22 common inhalant and food allergens. One hundred and seven children (30.1%) 
      were nonsensitized, 160 (44.9%) were monosensitized, and 89 (25.0%) were 
      polysensitized. Children who were mono- or polysensitized had a significantly 
      higher median serum LBP level (25.5 ng/mL, inter-quartile range [IQR] 20.3-30.7) 
      than those who were nonsensitized (20.3 ng/mL, IQR = 14.81-25.8, P < 0.0001). 
      Multivariate logistic regression analysis with adjustment for confounders 
      indicated that serum LBP level was positively associated with allergic 
      sensitization overall (adjusted odds ratio [aOR] 1.041; 95% CI 1.007-1.076, 
      P = 0.016), with sensitization to food allergens in particular (aOR 1.080, 95% CI 
      1.029-1.133, P = 0.002), but not with sensitization to aeroallergens (aOR 1.010, 
      95% CI 0.982-1.040, P = 0.467). LBP level was not associated with allergic 
      diseases after adjustment. We suggest the possibility of sensitization to food 
      allergens may be related to gut-derived low-grade inflammation, and large sized 
      longitudinal investigations are needed to elucidate the relationship.
FAU - Ha, Eun Kyo
AU  - Ha EK
AD  - Department of Pediatris, Hallym University Kangnam Sacred Heart Hospital, Seoul, 
      Republic of Korea.
FAU - Kim, Ju Hee
AU  - Kim JH
AD  - Department of Pediatrics, CHA Bundang Medical Center, CHA University School of 
      Medicine, CHA University, 351 Yatap-dong, Bundang-gu, Seongnam, Gyonggi-do, 
      13496, Republic of Korea.
FAU - Yon, Dong Keon
AU  - Yon DK
AD  - Department of Pediatrics, Seoul National University Hospital, Seoul National 
      University College of Medicine, Seoul, Republic of Korea.
FAU - Lee, Seung Won
AU  - Lee SW
AD  - Department of Data Science, Sejong University College of Software Convergence, 
      Seoul, Republic of Korea.
FAU - Kim, Mi Ae
AU  - Kim MA
AD  - Department of Internal Medicine, CHA Bundang Medical Center, CHA University, 
      Seongnam, Republic of Korea.
FAU - Lee, Kyung Suk
AU  - Lee KS
AD  - Department of Pediatrics, Hanyang University Guri Hospital, Hanyang University 
      College of Medicine, Guri, Republic of Korea.
FAU - Sung, Myongsoon
AU  - Sung M
AD  - Department of Pediatrics, Soon Chun Hyang University Gumi Hospital, Soon Chun 
      Hyang University College of Medicine, Gumi-si, Republic of Korea.
FAU - Jee, Hye Mi
AU  - Jee HM
AD  - Department of Pediatrics, CHA Bundang Medical Center, CHA University School of 
      Medicine, CHA University, 351 Yatap-dong, Bundang-gu, Seongnam, Gyonggi-do, 
      13496, Republic of Korea.
FAU - Shin, Youn Ho
AU  - Shin YH
AD  - Deparment of Pediatrics, CHA Gangnam Medical Center, CHA University School of 
      Medicine, CHA University, 566 Nonhyeon-ro, Gangnam-gu, Seoul, 06135, Republic of 
      Korea. epirubicin13@gmail.com.
FAU - Han, Man Yong
AU  - Han MY
AD  - Department of Pediatrics, CHA Bundang Medical Center, CHA University School of 
      Medicine, CHA University, 351 Yatap-dong, Bundang-gu, Seongnam, Gyonggi-do, 
      13496, Republic of Korea. drmesh@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210125
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Allergens)
RN  - 0 (Carrier Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (lipopolysaccharide-binding protein)
SB  - IM
MH  - Acute-Phase Proteins
MH  - Adolescent
MH  - Allergens/metabolism
MH  - Carrier Proteins/*blood
MH  - Child
MH  - Food Hypersensitivity/*blood
MH  - Humans
MH  - Membrane Glycoproteins/*blood
MH  - Odds Ratio
PMC - PMC7835372
COIS- The authors declare no competing interests.
EDAT- 2021/01/27 06:00
MHDA- 2021/09/18 06:00
PMCR- 2021/01/25
CRDT- 2021/01/26 05:43
PHST- 2020/01/07 00:00 [received]
PHST- 2020/10/19 00:00 [accepted]
PHST- 2021/01/26 05:43 [entrez]
PHST- 2021/01/27 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2021/01/25 00:00 [pmc-release]
AID - 10.1038/s41598-020-79241-x [pii]
AID - 79241 [pii]
AID - 10.1038/s41598-020-79241-x [doi]
PST - epublish
SO  - Sci Rep. 2021 Jan 25;11(1):2143. doi: 10.1038/s41598-020-79241-x.