PMID- 3349658
OWN - NLM
STAT- MEDLINE
DCOM- 19880422
LR  - 20190510
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 11
IP  - 1
DP  - 1988 Jan
TI  - Effect of ibopamine on the failing heart at rest and during isometric exercise: a 
      noninvasive study.
PG  - 15-22
AB  - Eleven patients suffering from heart failure were treated with oral ibopamine, a 
      di-isobutyric ester of N-methyldopamine, 100 mg three times a day for 1 week and 
      200 mg three times a day for 3 weeks. Therapy was discontinued by one patient 
      because of tachycardia. Left ventricular performance was evaluated with 
      echocardiography and systolic time intervals at rest and after 3 minutes of 
      isometric exercise using a handgrip. Six of 10 patients completing the study were 
      in New York Heart Association (NYHA) functional class III, 2 in class IV, and 2 
      in class II. All patients, except one who remained stable in class II, improved 
      their subjective condition by one functional class during 4 weeks of therapy (p 
      less than 0.01). There were no changes in heart rate, blood pressure, 
      rate-pressure product, cardiac index, or total peripheral vascular resistance. 
      The left ventricular end-systolic diameter decreased after four weeks from 71.2 
      +/- 12.7 (SD) to 65.9 +/- 13.0 mm (p less than 0.001); the left ventricular 
      end-diastolic diameter did not change. The ejection fraction increased from 26 
      +/- 8 to 32 +/- 9% (p less than 0.01). Afterload, that is, left ventricular 
      circumferential systolic wall stress, declined as a result of decreased systolic 
      diameter. Systolic time intervals did not vary. There were no changes due to 
      ibopamine during isometric exercise probably owing to increased beta-adrenergic 
      stimulation induced by the handgrip. Neither urine volume nor body weight 
      changed. Side effects were mild except for tachycardia of one patient.(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Partanen, J
AU  - Partanen J
AD  - First Department of Medicine, University Central Hospital, Helsinki, Finland.
FAU - Nieminen, M S
AU  - Nieminen MS
FAU - Lehto, H
AU  - Lehto H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Cardiotonic Agents)
RN  - 8ZCA2I2L11 (ibopamine)
RN  - R7339QLN1C (Deoxyepinephrine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Adult
MH  - Cardiotonic Agents/pharmacology/*therapeutic use
MH  - Deoxyepinephrine/*analogs & derivatives/pharmacology/therapeutic use
MH  - Dopamine/*analogs & derivatives
MH  - Heart Failure/*drug therapy
MH  - Hemodynamics/drug effects
MH  - Humans
MH  - Isometric Contraction
MH  - Male
MH  - Middle Aged
MH  - Rest
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.1002/clc.4960110112 [doi]
PST - ppublish
SO  - Clin Cardiol. 1988 Jan;11(1):15-22. doi: 10.1002/clc.4960110112.