PMID- 33497740
OWN - NLM
STAT- MEDLINE
DCOM- 20210705
LR  - 20210705
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 279
DP  - 2021 Aug 15
TI  - Aerobic exercise attenuates ectopic renal sinus adipose tissue 
      accumulation-related renal hypoxia injury in obese mice.
PG  - 119106
LID - S0024-3205(21)00091-6 [pii]
LID - 10.1016/j.lfs.2021.119106 [doi]
AB  - AIMS: We explored the effect of aerobic exercise on renal sinus adipose (RSA) 
      accumulation and RSA accumulation-related renal injury in obese mice. MAIN 
      METHODS: C57BL/6J male mice (n = 30) were evenly divided into three groups: 
      control group (CON, n = 10), obese group (OB, n = 10; given high-fat diet) and 
      obese + aerobic exercise group (OB + E, n = 10; given HFD and 8 weeks of 
      moderate-intensity exercise training). The body weight and kidney weight were 
      measured after sacrificing. Morphological alterations of adipose and renal 
      tissues were measured on hematoxylin-eosin (HE) stained slides. The macrophages 
      surface markers (F4/80, CD68, CD206, CD163), monocyte chemotactic protein 1 
      (MCP-1) and hypoxia inducible factor-1alpha (HIF-1alpha) were examined by 
      immunohistochemistry assay. Inflammation-related factors (FGF-21, KIM-1, IL-6) 
      were analyzed via serum enzyme-linked immunosorbent assay. KEY FINDINGS: We found 
      that aerobic exercise significantly reduced body weight, kidney weight, serum 
      FGF-21 and KIM-1 levels, and ameliorated glomerular hypertrophy and RSA size 
      accumulation in OB + E group compared with OB group. Furthermore, HIF-1alpha in the 
      RSA and renal tissues was significantly increased in the OB group (P < 0.05), but 
      exercise effectively reduced the expression of HIF-1alpha and ameliorated renal 
      inflammation by reducing MCP-1 and CD68 expression (both P < 0.05), improving the 
      conversion from M1 (CD68) to M2 (CD206, CD163) macrophages (P < 0.05), and 
      finally alleviating the level of IL-6 (P < 0.01). SIGNIFICANCE: Aerobic exercise 
      could reduce RSA accumulation-related adipose hypoxia and macrophage 
      infiltration, and subsequently attenuate the progress of renal injury.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Wang, Sha-Sha
AU  - Wang SS
AD  - School of Kinesiology, Shanghai University of Sport, Shanghai, China.
FAU - Gu, Qing
AU  - Gu Q
AD  - Department of Endocrinology, Shidong Hospital, Shanghai, China.
FAU - Liu, Nian
AU  - Liu N
AD  - School of Kinesiology, Shanghai University of Sport, Shanghai, China.
FAU - Li, Jingyuan
AU  - Li J
AD  - School of Kinesiology, Shanghai University of Sport, Shanghai, China.
FAU - Liu, Xiangyun
AU  - Liu X
AD  - School of Kinesiology, Shanghai University of Sport, Shanghai, China. Electronic 
      address: liuxiangyun@sus.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210123
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
SB  - IM
MH  - Adipose Tissue/*pathology
MH  - Animals
MH  - Diet, High-Fat/*adverse effects
MH  - Hypoxia/*physiopathology
MH  - Inflammation/*complications
MH  - Kidney Diseases/etiology/*prevention & control
MH  - Macrophages
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Obese
MH  - Obesity/*complications
MH  - *Physical Conditioning, Animal
OTO - NOTNLM
OT  - Aerobic exercise
OT  - Ectopic renal sinus adipose
OT  - Hypoxia
OT  - Inflammation
EDAT- 2021/01/27 06:00
MHDA- 2021/07/06 06:00
CRDT- 2021/01/26 20:09
PHST- 2020/12/14 00:00 [received]
PHST- 2021/01/02 00:00 [revised]
PHST- 2021/01/03 00:00 [accepted]
PHST- 2021/01/27 06:00 [pubmed]
PHST- 2021/07/06 06:00 [medline]
PHST- 2021/01/26 20:09 [entrez]
AID - S0024-3205(21)00091-6 [pii]
AID - 10.1016/j.lfs.2021.119106 [doi]
PST - ppublish
SO  - Life Sci. 2021 Aug 15;279:119106. doi: 10.1016/j.lfs.2021.119106. Epub 2021 Jan 
      23.