PMID- 33497820
OWN - NLM
STAT- MEDLINE
DCOM- 20210910
LR  - 20210910
IS  - 1879-260X (Electronic)
IS  - 0925-4439 (Linking)
VI  - 1867
IP  - 5
DP  - 2021 May 1
TI  - The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology.
PG  - 166085
LID - S0925-4439(21)00018-1 [pii]
LID - 10.1016/j.bbadis.2021.166085 [doi]
AB  - Activated by retinoids, metabolites of vitamin A, the retinoic acid receptors 
      (RARs) and the retinoid X receptors (RXRs) play important roles in a wide variety 
      of biological processes, including embryo development, homeostasis, cell 
      proliferation, differentiation and death. In this review, we summarized the 
      functional roles of nuclear receptor RAR/RXR heterodimers in liver physiology. 
      Specifically, RAR/RXR modulate the synthesis and metabolism of lipids and bile 
      acids in hepatocytes, regulate cholesterol transport in macrophages, and repress 
      fibrogenesis in hepatic stellate cells. We have also listed the specific genes 
      that carry these functions and how RAR/RXR regulate their expression in liver 
      cells, providing a mechanistic view of their roles in liver physiology. 
      Meanwhile, we pointed out many questions regarding the detailed signaling of 
      RAR/RXR in regulating the expression of liver genes, and hope future studies will 
      address these issues.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Li, Baixue
AU  - Li B
AD  - Liver Center, Yale University School of Medicine, New Haven, CT 06520, United 
      States; College of Basic Medical Sciences, Chengdu University of Traditional 
      Chinese Medicine, Chengdu 610075, China. Electronic address: baixue.li@yale.edu.
FAU - Cai, Shi-Ying
AU  - Cai SY
AD  - Liver Center, Yale University School of Medicine, New Haven, CT 06520, United 
      States. Electronic address: shi-ying.cai@yale.edu.
FAU - Boyer, James L
AU  - Boyer JL
AD  - Liver Center, Yale University School of Medicine, New Haven, CT 06520, United 
      States. Electronic address: james.boyer@yale.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210124
PL  - Netherlands
TA  - Biochim Biophys Acta Mol Basis Dis
JT  - Biochimica et biophysica acta. Molecular basis of disease
JID - 101731730
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
SB  - IM
MH  - Animals
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Liver/cytology/metabolism/*physiology
MH  - Protein Multimerization
MH  - Receptors, Retinoic Acid/chemistry/genetics/*metabolism
MH  - Retinoid X Receptors/chemistry/genetics/*metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - Bile acid hemostasis
OT  - Gene regulation
OT  - Lipid metabolism
OT  - Liver fibrogenesis
OT  - Liver physiology
OT  - Nuclear receptors
OT  - Retinoic acid receptors
OT  - Retinoid X receptors
EDAT- 2021/01/27 06:00
MHDA- 2021/09/11 06:00
CRDT- 2021/01/26 20:09
PHST- 2020/11/11 00:00 [received]
PHST- 2021/01/09 00:00 [revised]
PHST- 2021/01/12 00:00 [accepted]
PHST- 2021/01/27 06:00 [pubmed]
PHST- 2021/09/11 06:00 [medline]
PHST- 2021/01/26 20:09 [entrez]
AID - S0925-4439(21)00018-1 [pii]
AID - 10.1016/j.bbadis.2021.166085 [doi]
PST - ppublish
SO  - Biochim Biophys Acta Mol Basis Dis. 2021 May 1;1867(5):166085. doi: 
      10.1016/j.bbadis.2021.166085. Epub 2021 Jan 24.