PMID- 33499113
OWN - NLM
STAT- MEDLINE
DCOM- 20210909
LR  - 20210909
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 2
DP  - 2021 Jan 22
TI  - A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and 
      Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the 
      Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-kappaB Activation.
LID - 10.3390/nu13020311 [doi]
LID - 311
AB  - : Oleuropein (OL), an olive tree secoiridoid and its peracetylated derivate 
      (Per-OL) have exhibited several beneficial effects on LPS-stimulated macrophages 
      and murine experimental systemic lupus erythematosus (SLE). This study was 
      designed to evaluate dietary Per-OL in comparison with OL supplementation effects 
      on collagen-induced arthritis (CIA) murine model. Three-weeks-old DBA-1/J male 
      mice were fed from weaning with a standard commercial diet or experimental 
      enriched-diets in 0.05 % (w/w) OL, 0.05% and 0.025% Per-OL. After six weeks of 
      pre-treatment, arthritis was induced by bovine collagen type II by tail base 
      injection (day 0) and on day 21, mice received a booster injection. Mice were 
      sacrificed 42 days after the first immunization. Both Per-OL and OL diets 
      significantly prevented histological damage and arthritic score development, 
      although no statistically significant differences were observed between both 
      compounds. Also, serum collagen oligomeric matrix protein (COMP), metalloprotease 
      (MMP)-3 and pro-inflammatory cytokines levels were ameliorated in paws from 
      secoiridoids fed animals. Mitogen-activated protein kinases (MAPK)s and nuclear 
      transcription factor-kappa-B (NF-kappaB) activations were drastically down-regulated 
      whereas nuclear factor E2-related factor 2 (Nrf2) and heme-oxygenase-1 (HO-1) 
      protein expressions were up-regulated in those mice fed with OL and Per-OL diets. 
      We conclude that both Per-OL and its parent compound, OL, supplements might 
      provide a basis for developing a new dietary strategy for the prevention of 
      rheumatoid arthritis.
FAU - Castejon, Maria Luisa
AU  - Castejon ML
AUID- ORCID: 0000-0001-9865-4755
AD  - Department of Pharmacology, School of Pharmacy, University of Seville, 41012 
      Seville, Spain.
FAU - Alarcon-de-la-Lastra, Catalina
AU  - Alarcon-de-la-Lastra C
AD  - Department of Pharmacology, School of Pharmacy, University of Seville, 41012 
      Seville, Spain.
FAU - Rosillo, Maria Angeles
AU  - Rosillo MA
AD  - Department of Pharmacology, School of Pharmacy, University of Seville, 41012 
      Seville, Spain.
FAU - Montoya, Tatiana
AU  - Montoya T
AD  - Department of Pharmacology, School of Pharmacy, University of Seville, 41012 
      Seville, Spain.
FAU - Fernandez-Bolanos, Jose G
AU  - Fernandez-Bolanos JG
AD  - Department of Organic Chemistry, School of Chemistry, University of Seville, 
      41012 Seville, Spain.
FAU - Gonzalez-Benjumea, Alejandro
AU  - Gonzalez-Benjumea A
AUID- ORCID: 0000-0003-2857-9491
AD  - Department of Organic Chemistry, School of Chemistry, University of Seville, 
      41012 Seville, Spain.
FAU - Sanchez-Hidalgo, Marina
AU  - Sanchez-Hidalgo M
AUID- ORCID: 0000-0002-9210-2404
AD  - Department of Pharmacology, School of Pharmacy, University of Seville, 41012 
      Seville, Spain.
LA  - eng
PT  - Journal Article
DEP - 20210122
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Inflammasomes)
RN  - 0 (Iridoid Glucosides)
RN  - 0 (Membrane Proteins)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NF-kappa B)
RN  - 0 (Nfe2l2 protein, mouse)
RN  - 2O4553545L (oleuropein)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
RN  - EC 1.14.14.18 (Hmox1 protein, mouse)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.17 (Mmp3 protein, mouse)
SB  - IM
MH  - Animals
MH  - Arthritis, Experimental/chemically induced/*diet therapy/metabolism
MH  - Dietary Supplements
MH  - Disease Models, Animal
MH  - Heme Oxygenase-1/metabolism
MH  - Inflammasomes/*drug effects/metabolism
MH  - Iridoid Glucosides/*pharmacology
MH  - MAP Kinase Signaling System/drug effects
MH  - Male
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Membrane Proteins/metabolism
MH  - Mice
MH  - Mice, Inbred DBA
MH  - NF-E2-Related Factor 2/metabolism
MH  - NF-kappa B/drug effects
MH  - Signal Transduction/drug effects
PMC - PMC7911327
OTO - NOTNLM
OT  - CIA
OT  - MAPK
OT  - NF-kappaB
OT  - Nrf2/HO1
OT  - arthritis
OT  - inflammation
OT  - oleuropein
COIS- The authors have declared no conflicts of interest.
EDAT- 2021/01/28 06:00
MHDA- 2021/09/10 06:00
PMCR- 2021/01/22
CRDT- 2021/01/27 01:08
PHST- 2020/12/09 00:00 [received]
PHST- 2021/01/14 00:00 [revised]
PHST- 2021/01/15 00:00 [accepted]
PHST- 2021/01/27 01:08 [entrez]
PHST- 2021/01/28 06:00 [pubmed]
PHST- 2021/09/10 06:00 [medline]
PHST- 2021/01/22 00:00 [pmc-release]
AID - nu13020311 [pii]
AID - nutrients-13-00311 [pii]
AID - 10.3390/nu13020311 [doi]
PST - epublish
SO  - Nutrients. 2021 Jan 22;13(2):311. doi: 10.3390/nu13020311.