PMID- 33499713
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20220422
IS  - 1473-0790 (Electronic)
IS  - 1368-5538 (Linking)
VI  - 23
IP  - 5
DP  - 2020 Dec
TI  - Cross-sectional associations of adipokines and abdominal fat distribution with 
      aging in men.
PG  - 1576-1582
LID - 10.1080/13685538.2021.1876020 [doi]
AB  - OBJECTIVE: To investigate the relationship of adipokines and abdominal fat 
      distribution with aging in men. METHODS: In a cross-sectional study, a total of 
      218 participants aged 40-79 years were recruited as a subset of the Prospective 
      Urban Rural Epidemiology (PURE) China Action on Spine and Hip status (CASH) study 
      population. Analysis of variance (ANOVA) and multivariable regression were used 
      to estimate the associations of interest. RESULTS: With the increasing of age, 
      waist circumference, waist-to-hip ratio, waist-to-height ratio, total adipose 
      tissue (TAT), visceral adipose tissue (VAT), VAT/subcutaneous adipose tissue 
      (SAT), leptin, adiponectin-to-leptin ratio, and human monocyte chemo-attractant 
      protein-1 (MCP-1) increased significantly (p < 0.05), while adiponectin decreased 
      significantly (p < 0.05). Adiponectin, adiponectin/leptin, and 
      adiponectin/resistin varied inversely with the VAT quartiles (p < 0.05). There 
      was a significant negative correlation among adiponectin, adiponectin-to-leptin 
      ratio, adiponectin-to-resistin ratio, and all the body fat distribution 
      parameters. VAT was inversely and significantly associated with adiponectin, 
      adiponectin-to-leptin ratio, and adiponectin-to-resistin ratio (p < 0.05). 
      CONCLUSIONS: It showed that aging, abdominal fat distribution, and adipokines 
      were related with each other, which support the hypothesis that regulation of VAT 
      and adipokines is closely linked to aging.
FAU - Xu, Li
AU  - Xu L
AD  - Department of Radiology, Beijing Jishuitan Hospital, Beijing, China.
FAU - Lu, Yanhui
AU  - Lu Y
AD  - Department of Endocrinology, the Second Medical Centre, Chinese PLA General 
      Hospital, National Clinical Research Centre for Geriatric Disease, Beijing, 
      China.
FAU - Li, Nan
AU  - Li N
AD  - Department of Endocrinology, the Second Medical Centre, Chinese PLA General 
      Hospital, National Clinical Research Centre for Geriatric Disease, Beijing, 
      China.
FAU - Zhao, Qian
AU  - Zhao Q
AD  - International Medical Center, Sichuan University West China Hospital, Chengdu, 
      China.
FAU - Li, Kai
AU  - Li K
AD  - Department of Radiology, Beijing Jishuitan Hospital, Beijing, China.
FAU - Zhang, Yong
AU  - Zhang Y
AD  - Department of Radiology, Beijing Jishuitan Hospital, Beijing, China.
FAU - Liu, Yandong
AU  - Liu Y
AD  - Department of Radiology, Beijing Jishuitan Hospital, Beijing, China.
FAU - Li, Chunlin
AU  - Li C
AD  - Department of Endocrinology, the Second Medical Centre, Chinese PLA General 
      Hospital, National Clinical Research Centre for Geriatric Disease, Beijing, 
      China.
FAU - Cheng, Xiaoguang
AU  - Cheng X
AD  - Department of Radiology, Beijing Jishuitan Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20210127
PL  - England
TA  - Aging Male
JT  - The aging male : the official journal of the International Society for the Study 
      of the Aging Male
JID - 9808210
RN  - 0 (Adipokines)
SB  - IM
MH  - *Abdominal Fat
MH  - *Adipokines
MH  - Aging
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Male
MH  - Prospective Studies
OTO - NOTNLM
OT  - Adipokines
OT  - aging
OT  - visceral adipose tissue
EDAT- 2021/01/28 06:00
MHDA- 2021/10/26 06:00
CRDT- 2021/01/27 05:32
PHST- 2021/01/28 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/01/27 05:32 [entrez]
AID - 10.1080/13685538.2021.1876020 [doi]
PST - ppublish
SO  - Aging Male. 2020 Dec;23(5):1576-1582. doi: 10.1080/13685538.2021.1876020. Epub 
      2021 Jan 27.