PMID- 33501472
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1364-548X (Electronic)
IS  - 1359-7345 (Linking)
VI  - 57
IP  - 14
DP  - 2021 Feb 18
TI  - Single component photoresponsive fluorescent organic nanoparticles: a smart 
      platform for improved biomedical and agrochemical applications.
PG  - 1715-1733
LID - 10.1039/d0cc07183h [doi]
AB  - In the last two decades, light responsive nano drug delivery systems (DDSs) have 
      gained considerable importance, particularly in the area of biology and medicine. 
      In general, light responsive nano DDSs are bicomponent and constructed using two 
      ingredients, namely a nanocarrier and a phototrigger. The synthesis of these 
      bicomponent nano DDSs requires multiple steps, which limits their applications. 
      Hence, we have reported single component light responsive nano DDSs using 
      fluorescent organic nanoparticles (FONPs) which acted both as a nanocarrier and a 
      phototrigger. This feature article provides an overview of recently developed 
      light responsive single component FONPs and their applications in the regulated 
      release of anticancer drugs, gasotransmitters, antibacterial agents, and 
      pesticides, and also as efficient PDT agents. We have summarised the synthesis, 
      characterisation, and photophysical, photochemical, and in vitro behaviours of 
      these light responsive FONPs. In addition, we also discussed the advantages of 
      using FONPs as a nano DDS for cellular studies like: excellent biocompatibility, 
      efficient cellular internalisation, real time monitoring of the drug release 
      ability inside the cells, and enhanced cytotoxicity due to regulated release of 
      bioactive molecules inside the cells.
FAU - Chaudhuri, Amrita
AU  - Chaudhuri A
AD  - Department of Chemistry, Indian Institute of Technology Kharagpur, 721302 
      Kharagpur, West Bengal, India. ndpradeep@chem.iitkgp.ac.in.
FAU - Paul, Amrita
AU  - Paul A
FAU - Sikder, Antara
AU  - Sikder A
FAU - Pradeep Singh, N D
AU  - Pradeep Singh ND
LA  - eng
PT  - Journal Article
DEP - 20210127
PL  - England
TA  - Chem Commun (Camb)
JT  - Chemical communications (Cambridge, England)
JID - 9610838
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Photosensitizing Agents)
RN  - 0 (Stilbenes)
RN  - 0 (tetraphenylethylene)
SB  - IM
MH  - *Chemical Engineering
MH  - *Drug Delivery Systems
MH  - *Fluorescent Dyes
MH  - HeLa Cells
MH  - Humans
MH  - Molecular Structure
MH  - Nanoparticles/*chemistry
MH  - Photochemical Processes
MH  - Photochemotherapy
MH  - Photosensitizing Agents/*chemistry
MH  - Stilbenes/chemistry/pharmacology
EDAT- 2021/01/28 06:00
MHDA- 2021/06/22 06:00
CRDT- 2021/01/27 05:54
PHST- 2021/01/28 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2021/01/27 05:54 [entrez]
AID - 10.1039/d0cc07183h [doi]
PST - ppublish
SO  - Chem Commun (Camb). 2021 Feb 18;57(14):1715-1733. doi: 10.1039/d0cc07183h. Epub 
      2021 Jan 27.