PMID- 33502720
OWN - NLM
STAT- MEDLINE
DCOM- 20211012
LR  - 20211012
IS  - 1931-7565 (Electronic)
IS  - 1931-7557 (Linking)
VI  - 15
IP  - 5
DP  - 2021 Oct
TI  - Functional connectivity of posterior cingulate gyrus in heroin dependents treated 
      by methadone maintenance and protracted abstinence measures: an event-related 
      fMRI study.
PG  - 2472-2480
LID - 10.1007/s11682-020-00447-8 [doi]
AB  - Protracted abstinence (PA) and Methadone maintenance treatment (MMT) are two main 
      types of heroin addiction treatment, however, the effects of both measures on the 
      functional connectivity (FC) of the brain in heroin dependents in the drug cue 
      event-related response are unclear. Functional magnetic resonance imaging (fMRI) 
      based drug cue-reactivity task has been widely used in addiction research, which 
      may provide a new way to understand the change of brain function during a certain 
      period of treatment. The default function network (DMN) with posterior cingulate 
      cortex (PCC) as the core is generally involved in the process of addiction. The 
      aim of the present study was to explore the brain response of FC in patients with 
      heroin-dependent during PA, MMT treatment under task-fMRI. Twenty-two 
      heroin-dependent patients during PA, 18 heroin-dependent patients during MMT and 
      16 healthy control (HC) individuals were included to conduct the heroin 
      cue-reactivity task during fMRI. The MMT and PA patients' subjective craving for 
      heroin was evaluated. The psychophysiological interaction (PPI) analysis of SPM12 
      was used to get FC during the task state. There was a significant difference on 
      FC between PCC and the right medial Prefrontal Cortex (mPFC) in three groups. The 
      post-hoc analysis showed that there was a significant difference of brain regions 
      between the MMT and the PA group. The FC of PCC-mPFC in the MMT group was 
      significantly stronger than that in the PA group. Compared with the PA group, the 
      FC of the DMN in the MMT group was significantly increased under drug cue 
      response. Therefore, PA is more beneficial for the heroin-dependent patients to 
      lower the salience value of drug related cues, in turn to reduce relapse risks. 
      It also reflected the important role of PCC-mPFC pathway in heroin dependents 
      induced by heroin cues.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC part of Springer Nature.
FAU - Wei, Xuan
AU  - Wei X
AD  - Department of Radiology, Tangdu Hospital, Air Force Medical University, 569 Xinsi 
      Road, BaQiao District, Xi'an, 710038, Shaanxi, China.
AD  - Department of Radiology, Beijing Friendship Hospital, Capital Medical University, 
      No.95, Yong An Road, Xicheng District, Beijing, 100050, China.
FAU - Chen, Jiajie
AU  - Chen J
AD  - Department of Radiology, Tangdu Hospital, Air Force Medical University, 569 Xinsi 
      Road, BaQiao District, Xi'an, 710038, Shaanxi, China.
FAU - Zhu, Jia
AU  - Zhu J
AD  - Department of Radiology, Tangdu Hospital, Air Force Medical University, 569 Xinsi 
      Road, BaQiao District, Xi'an, 710038, Shaanxi, China.
FAU - Li, Qiang
AU  - Li Q
AUID- ORCID: 0000-0001-6732-4083
AD  - Department of Radiology, Tangdu Hospital, Air Force Medical University, 569 Xinsi 
      Road, BaQiao District, Xi'an, 710038, Shaanxi, China. tdqiangqiang@foxmail.com.
FAU - Li, Wei
AU  - Li W
AUID- ORCID: 0000-0002-6135-8538
AD  - Department of Radiology, Tangdu Hospital, Air Force Medical University, 569 Xinsi 
      Road, BaQiao District, Xi'an, 710038, Shaanxi, China. tdliwei777@126.com.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Radiology, Tangdu Hospital, Air Force Medical University, 569 Xinsi 
      Road, BaQiao District, Xi'an, 710038, Shaanxi, China.
LA  - eng
GR  - 81771813/National Natural Science Foundation of China/
GR  - 81671661/National Natural Science Foundation of China/
GR  - 81401393/National Natural Science Foundation of China/
GR  - 2013LCYJ003/Technology Innovation Development Foundation of Tangdu Hospital/
GR  - 2017XD062/Reserve Talents Foundation of Tangdu Hospital (2016) and Science and 
      Technology Development Fund of the fourth military medical university/
GR  - 2020M680607/China Postdoctoral Science Foundation/
GR  - yyqdkt2019-31/Research Foundation of Beijing Friendship Hospital, Capital Medical 
      University/
PT  - Journal Article
DEP - 20210127
PL  - United States
TA  - Brain Imaging Behav
JT  - Brain imaging and behavior
JID - 101300405
RN  - 70D95007SX (Heroin)
RN  - UC6VBE7V1Z (Methadone)
SB  - IM
MH  - Brain/diagnostic imaging
MH  - *Gyrus Cinguli
MH  - *Heroin
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Methadone
MH  - Opiate Substitution Treatment
OTO - NOTNLM
OT  - Craving
OT  - Heroin dependence
OT  - Methadone maintenance treatment
OT  - Protracted abstinence
OT  - Psychophysiological interaction
EDAT- 2021/01/28 06:00
MHDA- 2021/10/13 06:00
CRDT- 2021/01/27 12:17
PHST- 2020/12/29 00:00 [accepted]
PHST- 2021/01/28 06:00 [pubmed]
PHST- 2021/10/13 06:00 [medline]
PHST- 2021/01/27 12:17 [entrez]
AID - 10.1007/s11682-020-00447-8 [pii]
AID - 10.1007/s11682-020-00447-8 [doi]
PST - ppublish
SO  - Brain Imaging Behav. 2021 Oct;15(5):2472-2480. doi: 10.1007/s11682-020-00447-8. 
      Epub 2021 Jan 27.