PMID- 33503870
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210131
IS  - 2039-4330 (Print)
IS  - 2039-4349 (Electronic)
IS  - 2039-4330 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Jan 25
TI  - Human Leukocyte Antigen (HLA) Influence on Prognosis of Autoimmune Hearing Loss.
PG  - 31-37
LID - 10.3390/audiolres11010004 [doi]
AB  - BACKGROUND: To evaluate the effect of human leukocyte antigen (HLA) on hearing 
      outcome in patients suffering from autoimmune hearing loss (AIHL). MATERIALS AND 
      METHODS: The diagnosis of AIHL was essentially based on clinical symptoms, such 
      as recurrent, sudden, fluctuating, or quickly progressing (<12 months) 
      sensorineural hearing loss (uni-/bilateral). The molecular typing of HLA alleles 
      was achieved by using polymerase chain reaction procedures. Patients underwent a 
      tapering schema of steroid treatment and audiometric features were recorded. A 
      logistic regression model was used to identify which HLA typing alleles were 
      statistically significant in patients' response to treatment. RESULTS: Forty 
      patients with AIHL were found to be carriers of HLA B27, B35, B51, C4, C7, and 
      DRB1*04 alleles. No statistically significant influence of HLA B27, B35, B51, C4, 
      C7, DRB1*04 HLA alleles typing was detected for the prognosis of AIHL. In these 
      patients, the onset of AIHL was mainly progressive (53.8%), 29.2% of them had 
      moderate hearing loss, and most of the cases had both bilateral hearing loss 
      (62.5%) and downsloping audiogram (40%). CONCLUSION: The presence of HLA B27, 
      B35, B51, C4, C7, and DRB1*04 alleles had no significant effect on a favorable 
      outcome of AIHL. However, larger samples of patients are necessary in order to 
      improve the knowledge about the HLA influence on the clinical course of AIHL.
FAU - Psillas, George
AU  - Psillas G
AUID- ORCID: 0000-0003-3509-6519
AD  - 1st Academic ENT Department, Aristotle University of Thessaloniki, AHEPA 
      Hospital, 546 36 Thessaloniki, Greece.
FAU - Binos, Paris
AU  - Binos P
AUID- ORCID: 0000-0003-3850-1866
AD  - Department of Rehabilitation, Cyprus University of Technology, Archiepiskopou 
      Kyprianou 30, Limassol 3036, Cyprus.
FAU - Dimas, Grigorios G
AU  - Dimas GG
AD  - 1st Propedeutic Department of Internal Medicine, Aristotle University of 
      Thessaloniki, AHEPA Hospital, 546 36 Thessaloniki, Greece.
FAU - Daniilidis, Michalis
AU  - Daniilidis M
AD  - 1st Internal Medicine Department, Aristotle University of Thessaloniki, AHEPA 
      Hospital, 546 36 Thessaloniki, Greece.
FAU - Constantinidis, Jiannis
AU  - Constantinidis J
AD  - 1st Academic ENT Department, Aristotle University of Thessaloniki, AHEPA 
      Hospital, 546 36 Thessaloniki, Greece.
LA  - eng
PT  - Journal Article
DEP - 20210125
PL  - Switzerland
TA  - Audiol Res
JT  - Audiology research
JID - 101644681
PMC - PMC7838950
OTO - NOTNLM
OT  - HLA antigens
OT  - HLA-DRB1* alleles
OT  - autoantibodies
OT  - autoimmunity
OT  - hearing loss
COIS- The authors declare no conflict of interest.
EDAT- 2021/01/29 06:00
MHDA- 2021/01/29 06:01
PMCR- 2021/01/25
CRDT- 2021/01/28 01:02
PHST- 2020/11/24 00:00 [received]
PHST- 2020/12/31 00:00 [revised]
PHST- 2021/01/21 00:00 [accepted]
PHST- 2021/01/28 01:02 [entrez]
PHST- 2021/01/29 06:00 [pubmed]
PHST- 2021/01/29 06:01 [medline]
PHST- 2021/01/25 00:00 [pmc-release]
AID - audiolres11010004 [pii]
AID - audiolres-11-00004 [pii]
AID - 10.3390/audiolres11010004 [doi]
PST - epublish
SO  - Audiol Res. 2021 Jan 25;11(1):31-37. doi: 10.3390/audiolres11010004.