PMID- 33503931
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210316
IS  - 2079-4991 (Print)
IS  - 2079-4991 (Electronic)
IS  - 2079-4991 (Linking)
VI  - 11
IP  - 2
DP  - 2021 Jan 25
TI  - Feasibility of Application of the Newly Developed Nano-Biomaterial, beta-TCP/PDLLA, 
      in Maxillofacial Reconstructive Surgery: A Pilot Rat Study.
LID - 10.3390/nano11020303 [doi]
LID - 303
AB  - This study was performed to examine the applicability of the newly developed 
      nano-biocomposite, beta-tricalcium phosphate (beta-TCP)/u-HA/poly-d/l-lactide (PDLLA), 
      to bone defects in the oral and maxillofacial area. This novel nano-biocomposite 
      showed several advantages, including biocompatibility, biodegradability, and 
      osteoconductivity. In addition, its optimal plasticity also allowed its 
      utilization in irregular critical bone defect reconstructive surgery. Here, three 
      different nano-biomaterials, i.e., beta-TCP/PDLLA, beta-TCP, and PDLLA, were implanted 
      into critical bone defects in the right lateral mandible of 10-week-old 
      Sprague-Dawley (SD) rats as bone graft substitutes. Micro-computed tomography 
      (Micro-CT) and immunohistochemical staining for the osteogenesis biomarkers, 
      Runx2, osteocalcin, and the leptin receptor, were performed to investigate and 
      compare bone regeneration between the groups. Although the micro-CT results 
      showed the highest bone mineral density (BMD) and bone volume to total volume 
      (BV/TV) with beta-TCP, immunohistochemical analysis indicated better 
      osteogenesis-promoting ability of beta-TCP/PDLLA, especially at an early stage of 
      the bone healing process. These results confirmed that the novel 
      nano-biocomposite, beta-TCP/PDLLA, which has excellent biocompatibility, 
      bioresorbability and bioactive/osteoconductivity, has the potential to become a 
      next-generation biomaterial for use as a bone graft substitute in maxillofacial 
      reconstructive surgery.
FAU - Toda, Erina
AU  - Toda E
AD  - Department of Oral and Maxillofacial Surgery, Shimane University Faculty of 
      Medicine, 89-1 Enya-Cho, Izumo 693-8501, Shimane, Japan.
FAU - Bai, Yunpeng
AU  - Bai Y
AUID- ORCID: 0000-0001-6087-2095
AD  - Department of Oral and Maxillofacial Surgery, Shimane University Faculty of 
      Medicine, 89-1 Enya-Cho, Izumo 693-8501, Shimane, Japan.
FAU - Sha, Jingjing
AU  - Sha J
AD  - Department of Oral and Maxillofacial Surgery, Shimane University Faculty of 
      Medicine, 89-1 Enya-Cho, Izumo 693-8501, Shimane, Japan.
FAU - Dong, Quang Ngoc
AU  - Dong QN
AD  - Department of Oral and Maxillofacial Surgery, Shimane University Faculty of 
      Medicine, 89-1 Enya-Cho, Izumo 693-8501, Shimane, Japan.
FAU - Ngo, Huy Xuan
AU  - Ngo HX
AD  - Department of Oral and Maxillofacial Surgery, Shimane University Faculty of 
      Medicine, 89-1 Enya-Cho, Izumo 693-8501, Shimane, Japan.
FAU - Suyama, Takashi
AU  - Suyama T
AD  - Department of Life Science, Shimane University Faculty of Medicine, 89-1 
      Enya-Cho, Izumo 693-8501, Shimane, Japan.
FAU - Miyamoto, Kenichi
AU  - Miyamoto K
AD  - Department of Life Science, Shimane University Faculty of Medicine, 89-1 
      Enya-Cho, Izumo 693-8501, Shimane, Japan.
FAU - Matsuzaki, Yumi
AU  - Matsuzaki Y
AD  - Department of Life Science, Shimane University Faculty of Medicine, 89-1 
      Enya-Cho, Izumo 693-8501, Shimane, Japan.
FAU - Kanno, Takahiro
AU  - Kanno T
AD  - Department of Oral and Maxillofacial Surgery, Shimane University Faculty of 
      Medicine, 89-1 Enya-Cho, Izumo 693-8501, Shimane, Japan.
LA  - eng
GR  - #17K11803/JSPS KAKENHI/
PT  - Journal Article
DEP - 20210125
PL  - Switzerland
TA  - Nanomaterials (Basel)
JT  - Nanomaterials (Basel, Switzerland)
JID - 101610216
PMC - PMC7912080
OTO - NOTNLM
OT  - Runx2
OT  - biocompatibility
OT  - leptin receptor
OT  - osteocalcin
OT  - osteoconductivity
OT  - beta-TCP/PDLLA
COIS- The authors have no conflicts of interest to declare.
EDAT- 2021/01/29 06:00
MHDA- 2021/01/29 06:01
PMCR- 2021/01/25
CRDT- 2021/01/28 01:02
PHST- 2020/12/03 00:00 [received]
PHST- 2021/01/17 00:00 [revised]
PHST- 2021/01/22 00:00 [accepted]
PHST- 2021/01/28 01:02 [entrez]
PHST- 2021/01/29 06:00 [pubmed]
PHST- 2021/01/29 06:01 [medline]
PHST- 2021/01/25 00:00 [pmc-release]
AID - nano11020303 [pii]
AID - nanomaterials-11-00303 [pii]
AID - 10.3390/nano11020303 [doi]
PST - epublish
SO  - Nanomaterials (Basel). 2021 Jan 25;11(2):303. doi: 10.3390/nano11020303.