PMID- 33505457
OWN - NLM
STAT- MEDLINE
DCOM- 20211027
LR  - 20211027
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2021
DP  - 2021
TI  - Voxel-Wise Brain-Wide Functional Connectivity Abnormalities in Patients with 
      Primary Blepharospasm at Rest.
PG  - 6611703
LID - 10.1155/2021/6611703 [doi]
LID - 6611703
AB  - BACKGROUND: Primary blepharospasm (BSP) is one of the most common focal dystonia 
      and its pathophysiological mechanism remains unclear. An unbiased method was used 
      in patients with BSP at rest to observe voxel-wise brain-wide functional 
      connectivity (FC) changes. METHOD: A total of 48 subjects, including 24 untreated 
      patients with BSP and 24 healthy controls, were recruited to undergo functional 
      magnetic resonance imaging (fMRI). The method of global-brain FC (GFC) was 
      adopted to analyze the resting-state fMRI data. We designed the support vector 
      machine (SVM) method to determine whether GFC abnormalities could be utilized to 
      distinguish the patients from the controls. RESULTS: Relative to healthy 
      controls, patients with BSP showed significantly decreased GFC in the bilateral 
      superior medial prefrontal cortex/anterior cingulate cortex (MPFC/ACC) and 
      increased GFC in the right postcentral gyrus/precentral gyrus/paracentral lobule, 
      right superior frontal gyrus (SFG), and left paracentral lobule/supplement motor 
      area (SMA), which were included in the default mode network (DMN) and 
      sensorimotor network. SVM analysis showed that increased GFC values in the right 
      postcentral gyrus/precentral gyrus/paracentral lobule could discriminate patients 
      from controls with optimal accuracy, specificity, and sensitivity of 83.33%, 
      83.33%, and 83.33%, respectively. CONCLUSION: This study suggested that abnormal 
      GFC in the brain areas associated with sensorimotor network and DMN might 
      underlie the pathophysiology of BSP, which provided a new perspective to 
      understand BSP. GFC in the right postcentral gyrus/precentral gyrus/paracentral 
      lobule might be utilized as a latent biomarker to differentiate patients with BSP 
      from controls.
CI  - Copyright (c) 2021 Pan Pan et al.
FAU - Pan, Pan
AU  - Pan P
AD  - National Clinical Research Center for Mental Disorders, and Department of 
      Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 
      410011 Hunan, China.
FAU - Wei, Shubao
AU  - Wei S
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi 530021, China.
FAU - Li, Huabing
AU  - Li H
AD  - Department of Radiology, The Second Xiangya Hospital of Central South University, 
      Changsha, 410011 Hunan, China.
FAU - Ou, Yangpan
AU  - Ou Y
AD  - National Clinical Research Center for Mental Disorders, and Department of 
      Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 
      410011 Hunan, China.
FAU - Liu, Feng
AU  - Liu F
AD  - Department of Radiology, Tianjin Medical University General Hospital, Tianjin 
      300000, China.
FAU - Jiang, Wenyan
AU  - Jiang W
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi 530021, China.
FAU - Li, Wenmei
AU  - Li W
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi 530021, China.
FAU - Lei, Yiwu
AU  - Lei Y
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi 530021, China.
FAU - Tang, Yanqing
AU  - Tang Y
AD  - Department of Psychiatry, The First Affiliated Hospital of China Medical 
      University, Shenyang, Liaoning 110001, China.
FAU - Guo, Wenbin
AU  - Guo W
AUID- ORCID: 0000-0002-1626-2465
AD  - National Clinical Research Center for Mental Disorders, and Department of 
      Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 
      410011 Hunan, China.
AD  - Department of Psychiatry, The Third People's Hospital of Foshan, Foshan, 
      Guangdong 528000, China.
FAU - Luo, Shuguang
AU  - Luo S
AUID- ORCID: 0000-0002-4082-6136
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi 530021, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210106
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
RN  - Benign essential blepharospasm
SB  - IM
MH  - Adult
MH  - Blepharospasm/*diagnostic imaging/physiopathology
MH  - Brain/*diagnostic imaging/physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/*diagnostic imaging/physiopathology
MH  - Rest/*physiology
PMC - PMC7808842
COIS- The authors declare that there is no conflict of interests to disclose.
EDAT- 2021/01/29 06:00
MHDA- 2021/10/28 06:00
PMCR- 2021/01/06
CRDT- 2021/01/28 05:42
PHST- 2020/11/06 00:00 [received]
PHST- 2020/12/22 00:00 [revised]
PHST- 2020/12/24 00:00 [accepted]
PHST- 2021/01/28 05:42 [entrez]
PHST- 2021/01/29 06:00 [pubmed]
PHST- 2021/10/28 06:00 [medline]
PHST- 2021/01/06 00:00 [pmc-release]
AID - 10.1155/2021/6611703 [doi]
PST - epublish
SO  - Neural Plast. 2021 Jan 6;2021:6611703. doi: 10.1155/2021/6611703. eCollection 
      2021.