PMID- 33506043
OWN - NLM
STAT- MEDLINE
DCOM- 20210528
LR  - 20210528
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2021
DP  - 2021
TI  - Association between Depression, Antidepression Medications, and the Risk of 
      Developing Type 2 Diabetes Mellitus: A Nationwide Population-Based Retrospective 
      Cohort Study in Taiwan.
PG  - 8857230
LID - 10.1155/2021/8857230 [doi]
LID - 8857230
AB  - The relationship between depression, antidepressant medications (ADMs), and the 
      risk of subsequent type 2 diabetes mellitus (T2DM) development remains 
      controversial. Thus, we investigated this aspect by a population-based 
      retrospective cohort study using the Longitudinal Health Insurance Database 2000 
      available in Taiwan. This large, observational study included 46,201 patients 
      with depression and a 1 : 1 age- and sex-matched nondepression cohort enrolled 
      between January 1, 2000, and December 31, 2013, and the newly diagnosed T2DM 
      incidence rates were determined. We estimated the effects of depression on T2DM 
      and the cumulative incidence curves by Cox proportional regression hazard models 
      and Kaplan-Meier methods, respectively. We found that 47.97% of the patients with 
      depression did not receive ADM. Among patients with depression who received ADM, 
      29.71%, 6.29%, 0.05%, 9.65%, and 6.32% received selective serotonin reuptake 
      inhibitors (SSRIs), tricyclic antidepressants (TCAs), monoamine oxidase 
      inhibitors (MAOIs), heterocyclic antidepressants, and other medications, 
      respectively. Patients without ADM treatment had a 39% higher risk of developing 
      T2DM. However, those who received ADM treatment had a significantly lower risk of 
      T2DM development in every treatment category. Depressive disorder treated with 
      ADMs, especially with long-term use, was associated with an 11-48% decrease in 
      the risk of T2DM in all ADM groups; however, heterocyclic antidepressant 
      treatment for shorter periods (<80 days) was not significantly associated with a 
      decreased risk of T2DM. The incidence of T2DM in Taiwan was found to be 
      associated with an a priori history of depression and was inversely correlated 
      with ADM treatment.
CI  - Copyright (c) 2021 Yi-Jen Fang et al.
FAU - Fang, Yi-Jen
AU  - Fang YJ
AD  - Research Center for Environmental Medicine, Kaohsiung Medical University, 
      Kaohsiung, Taiwan.
AD  - Ph.D. Program in Environmental and Occupational Medicine, College of Medicine, 
      Kaohsiung Medical University and National Health Research Institutes, Taiwan.
AD  - Graduate Institute of Clinical Medicine, Department of Environmental Health, 
      Kaohsiung Medical University, Kaohsiung, Taiwan.
AD  - National Institute of Environmental Health Sciences, National Health Research 
      Institutes, Zhunan, Taiwan.
AD  - Digestive Disease Center, Show Chwan Memorial Hospital, Changhua, Taiwan.
FAU - Wu, Tien-Yuan
AU  - Wu TY
AD  - Department of Pharmacy, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical 
      Foundation, Taichung, Taiwan.
AD  - Department of Pharmacology, School of Medicine, Tzu Chi University, Hualien, 
      Taiwan.
FAU - Lai, Jung-Nien
AU  - Lai JN
AD  - Department of Chinese Medicine, China Medical University Hospital, Taichung, 
      Taiwan.
AD  - School of Chinese Medicine, College of Chinese Medicine, China Medical 
      University, Taichung, Taiwan.
FAU - Lin, Cheng-Li
AU  - Lin CL
AD  - Management Office for Health Data, China Medical University Hospital, Taichung, 
      Taiwan.
FAU - Tien, Ni
AU  - Tien N
AD  - Department of Laboratory Medicine, China Medical University Hospital, Taichung, 
      Taiwan.
AD  - Department of Medical Laboratory Science and Biotechnology, China Medical 
      University, Taichung, Taiwan.
FAU - Lim, Yun-Ping
AU  - Lim YP
AUID- ORCID: 0000-0001-9312-048X
AD  - Department of Pharmacy, College of Pharmacy, China Medical University, Taichung, 
      Taiwan.
AD  - Department of Internal Medicine, China Medical University Hospital, Taichung, 
      Taiwan.
AD  - Department of Medical Research, China Medical University Hospital, Taichung, 
      Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20210107
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antidepressive Agents/*therapeutic use
MH  - Comorbidity
MH  - *Depression/complications/drug therapy/epidemiology
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Taiwan
PMC - PMC7810559
COIS- The authors declare no conflict of interest.
EDAT- 2021/01/29 06:00
MHDA- 2021/05/29 06:00
PMCR- 2021/01/07
CRDT- 2021/01/28 05:44
PHST- 2020/08/31 00:00 [received]
PHST- 2020/12/22 00:00 [revised]
PHST- 2020/12/26 00:00 [accepted]
PHST- 2021/01/28 05:44 [entrez]
PHST- 2021/01/29 06:00 [pubmed]
PHST- 2021/05/29 06:00 [medline]
PHST- 2021/01/07 00:00 [pmc-release]
AID - 10.1155/2021/8857230 [doi]
PST - epublish
SO  - Biomed Res Int. 2021 Jan 7;2021:8857230. doi: 10.1155/2021/8857230. eCollection 
      2021.