PMID- 33506345
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20220201
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Print)
IS  - 1569-5794 (Linking)
VI  - 37
IP  - 5
DP  - 2021 May
TI  - Combining perfusion and angiography with a low-dose cardiac CT technique: a 
      preliminary investigation in a swine model.
PG  - 1767-1779
LID - 10.1007/s10554-020-02130-x [doi]
AB  - Morphological and physiological assessment of coronary artery disease (CAD) is 
      necessary for proper stratification of CAD risk. The objective was to evaluate a 
      low-dose cardiac CT technique that combines morphological and physiological 
      assessment of CAD. The low-dose technique was evaluated in twelve swine, where 
      three of the twelve had coronary balloon stenosis. The technique consisted of 
      rest perfusion measurement combined with angiography followed by stress perfusion 
      measurement, where the ratio of stress to rest was used to derive coronary flow 
      reserve (CFR). The technique only required two volume scans for perfusion 
      measurement in mL/min/g; hence, four volume scans were acquired in total; two for 
      rest with angiography and two for stress. All rest, stress, and CFR measurements 
      were compared to a previously validated reference technique that employed 20 
      consecutive volume scans for rest perfusion measurement combined with 
      angiography, and stress perfusion measurement, respectively. The 32 cm diameter 
      volumetric CT dose index ([Formula: see text]) and size-specific dose estimate 
      (SSDE) of the low-dose technique were also recorded. All low-dose perfusion 
      measurements (P(LOW)) in mL/min/g were related to reference perfusion 
      measurements (P(REF)) through regression by P(LOW) = 1.04 P(REF) - 0.08 
      (r = 0.94, RMSE = 0.32 mL/min/g). The [Formula: see text] and SSDE of the 
      low-dose cardiac CT technique were 8.05 mGy and 12.80 mGy respectively, 
      corresponding to an estimated effective dose and size-specific effective dose of 
      1.8 and 2.87 mSv, respectively. Combined morphological and physiological 
      assessment of coronary artery disease is feasible using a low-dose cardiac CT 
      technique.
FAU - Hubbard, Logan
AU  - Hubbard L
AUID- ORCID: 0000-0003-2238-5768
AD  - Department of Radiological Sciences, Medical Sciences I, B-140, University of 
      California, Irvine, CA, 92697, USA.
FAU - Malkasian, Shant
AU  - Malkasian S
AD  - Department of Radiological Sciences, Medical Sciences I, B-140, University of 
      California, Irvine, CA, 92697, USA.
FAU - Zhao, Yixiao
AU  - Zhao Y
AD  - Department of Radiological Sciences, Medical Sciences I, B-140, University of 
      California, Irvine, CA, 92697, USA.
FAU - Abbona, Pablo
AU  - Abbona P
AD  - Department of Radiological Sciences, Medical Sciences I, B-140, University of 
      California, Irvine, CA, 92697, USA.
FAU - Molloi, Sabee
AU  - Molloi S
AUID- ORCID: 0000-0003-1852-4913
AD  - Department of Radiological Sciences, Medical Sciences I, B-140, University of 
      California, Irvine, CA, 92697, USA. symolloi@uci.edu.
LA  - eng
GR  - T32 HL116270/HL/NHLBI NIH HHS/United States
GR  - 17CPRE33650059/American Heart Association/
GR  - 1F30HL13728801A1/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20210127
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
SB  - IM
MH  - Animals
MH  - Computed Tomography Angiography
MH  - Coronary Angiography
MH  - *Coronary Artery Disease/diagnostic imaging
MH  - *Fractional Flow Reserve, Myocardial
MH  - *Myocardial Perfusion Imaging
MH  - Perfusion
MH  - Predictive Value of Tests
MH  - Swine
MH  - Tomography, X-Ray Computed
PMC - PMC8105235
OTO - NOTNLM
OT  - Computed tomography angiography
OT  - Coronary artery disease
OT  - Coronary flow reserve
OT  - Myocardial perfusion imaging
COIS- The authors do not have any conflicts-of-interest or competing interests to 
      disclose.
EDAT- 2021/01/29 06:00
MHDA- 2021/10/16 06:00
PMCR- 2021/01/27
CRDT- 2021/01/28 05:46
PHST- 2020/10/18 00:00 [received]
PHST- 2020/12/04 00:00 [accepted]
PHST- 2021/01/29 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2021/01/28 05:46 [entrez]
PHST- 2021/01/27 00:00 [pmc-release]
AID - 10.1007/s10554-020-02130-x [pii]
AID - 2130 [pii]
AID - 10.1007/s10554-020-02130-x [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2021 May;37(5):1767-1779. doi: 
      10.1007/s10554-020-02130-x. Epub 2021 Jan 27.