PMID- 33506361 OWN - NLM STAT- MEDLINE DCOM- 20211015 LR - 20211015 IS - 1437-2320 (Electronic) IS - 0344-5607 (Linking) VI - 44 IP - 5 DP - 2021 Oct TI - Hyperhomocysteinemia is a risk factor for postoperative ischemia in adult patients with moyamoya disease. PG - 2913-2921 LID - 10.1007/s10143-021-01482-9 [doi] AB - Growing evidence has suggested that hyperhomocysteinemia (HHcy) is a risk factor for cerebral infarction. However, the effect of HHcy on postoperative cerebral ischemia is still unclear. We aim to investigate the relationship between HHcy and postoperative ischemia of adult patients with moyamoya disease (MMD). A total of 138 adult patients with MMD were prospectively recruited from July 1 to December 31, 2019. After excluding 14 patients accepting conservative therapy, all 124 patients who underwent surgical treatment were enrolled. Patients were grouped according to postoperative ischemia and HHcy presentation, respectively. Clinical data and laboratory examinations were compared by statistical analyses. Potential risk factors were evaluated by univariate and multivariate logistic regression analysis. Comparing to the normal, patients with postoperative ischemia were higher in serum homocysteine (Hcy) level (P = 0.039) and HHcy ratio (P = 0.035). Furthermore, HHcy was more common in males (P = 0.007) than females. Logistic analysis results showed that HHcy (OR 5.234, 95% CI 1.127-24.315; P = 0.035) was an independent risk factor. HHcy was significantly associated with postoperative ischemia in MMD patients. Our study found that HHcy was correlated to the risk of postoperative ischemia. HHcy can be used as an indicator and a potential therapeutic target for postoperative ischemia in adult patients with MMD. URL: http://www.chictr.org . Unique identifier: ChiCTR2000031412. CI - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature. FAU - Li, Junsheng AU - Li J AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Nan Si Huan Xi Road 119, Fengtai District, Beijing, 100070, China. AD - China National Clinical Research Center for Neurological Diseases, Beijing, China. AD - Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. AD - Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. AD - Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China. FAU - Ge, Peicong AU - Ge P AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Nan Si Huan Xi Road 119, Fengtai District, Beijing, 100070, China. AD - China National Clinical Research Center for Neurological Diseases, Beijing, China. AD - Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. AD - Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. AD - Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China. FAU - Zhang, Qian AU - Zhang Q AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Nan Si Huan Xi Road 119, Fengtai District, Beijing, 100070, China. AD - China National Clinical Research Center for Neurological Diseases, Beijing, China. AD - Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. AD - Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. AD - Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China. FAU - Lin, Fa AU - Lin F AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Nan Si Huan Xi Road 119, Fengtai District, Beijing, 100070, China. AD - China National Clinical Research Center for Neurological Diseases, Beijing, China. AD - Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. AD - Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. AD - Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China. FAU - Wang, Rong AU - Wang R AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Nan Si Huan Xi Road 119, Fengtai District, Beijing, 100070, China. AD - China National Clinical Research Center for Neurological Diseases, Beijing, China. AD - Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. AD - Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. AD - Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China. FAU - Zhang, Yan AU - Zhang Y AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Nan Si Huan Xi Road 119, Fengtai District, Beijing, 100070, China. AD - China National Clinical Research Center for Neurological Diseases, Beijing, China. AD - Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. AD - Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. AD - Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China. FAU - Zhang, Dong AU - Zhang D AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Nan Si Huan Xi Road 119, Fengtai District, Beijing, 100070, China. AD - China National Clinical Research Center for Neurological Diseases, Beijing, China. AD - Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. AD - Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. AD - Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China. FAU - Wang, Wen AU - Wang W AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Nan Si Huan Xi Road 119, Fengtai District, Beijing, 100070, China. wangwenttyy@126.com. AD - China National Clinical Research Center for Neurological Diseases, Beijing, China. wangwenttyy@126.com. AD - Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. wangwenttyy@126.com. AD - Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. wangwenttyy@126.com. AD - Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China. wangwenttyy@126.com. FAU - Zhao, Jizong AU - Zhao J AUID- ORCID: 0000-0001-7304-0255 AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Nan Si Huan Xi Road 119, Fengtai District, Beijing, 100070, China. zhaojz205@163.com. AD - China National Clinical Research Center for Neurological Diseases, Beijing, China. zhaojz205@163.com. AD - Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. zhaojz205@163.com. AD - Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. zhaojz205@163.com. AD - Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China. zhaojz205@163.com. AD - Savaid Medical School, University of the Chinese Academy of Sciences, Beijing, China. zhaojz205@163.com. LA - eng PT - Journal Article DEP - 20210127 PL - Germany TA - Neurosurg Rev JT - Neurosurgical review JID - 7908181 SB - IM MH - Adult MH - *Brain Ischemia/epidemiology/etiology MH - Cerebral Infarction MH - Female MH - Humans MH - *Hyperhomocysteinemia/complications/epidemiology MH - Male MH - *Moyamoya Disease/complications/epidemiology/surgery MH - Risk Factors OTO - NOTNLM OT - Homocysteine OT - Hyperhomocysteinemia OT - Moyamoya disease OT - Postoperative ischemia OT - Risk factor EDAT- 2021/01/29 06:00 MHDA- 2021/10/16 06:00 CRDT- 2021/01/28 05:46 PHST- 2020/11/09 00:00 [received] PHST- 2021/01/21 00:00 [accepted] PHST- 2020/12/14 00:00 [revised] PHST- 2021/01/29 06:00 [pubmed] PHST- 2021/10/16 06:00 [medline] PHST- 2021/01/28 05:46 [entrez] AID - 10.1007/s10143-021-01482-9 [pii] AID - 10.1007/s10143-021-01482-9 [doi] PST - ppublish SO - Neurosurg Rev. 2021 Oct;44(5):2913-2921. doi: 10.1007/s10143-021-01482-9. Epub 2021 Jan 27.