PMID- 33506449
OWN - NLM
STAT- MEDLINE
DCOM- 20210312
LR  - 20210312
IS  - 1439-7803 (Electronic)
IS  - 0044-2771 (Linking)
VI  - 59
IP  - 3
DP  - 2021 Mar
TI  - Gastric NET Subtypes: Do We Need An Additional One?
PG  - 255-258
LID - 10.1055/a-1348-2727 [doi]
AB  - Depending on etiology, prognosis and malignant potential, recent S2k guideline 
      differentiates gastric neuroendocrine tumors (gNET) in 4 types with different 
      treatment implications.We report on a 55-year-old patient with the accidental 
      finding of a 15 mm gNET. Apart from a prolonged use of proton pump inhibitors 
      (PPI) for 20 years as a treatment for gastroesophageal reflux disease, there were 
      no other associations or risk factors for gNETs. Formally, this patient would 
      have been classified as a type III gNET, implicating gastric surgery. From a 
      pathophysiological point of view, however, the assumed prolonged gastrin 
      hypersecretion would have justified an assignment as a type I gNET. The gNET was 
      resected by ESD, but histology showed an R1 situation. After cessation of PPIs, 
      there is no recurrence so far. Besides, the initially documented numerous and 
      large gland polyps showed an impressive regression only a few weeks after 
      cessation of PPI.This case points to a probably underestimated gap in the present 
      gNET classification. On the basis of present literature, the therapeutic dilemma 
      of PPI-associated gNETs is discussed. A new assignment of PPI associated gNETs as 
      type Ib could help to overcome this dilemma.
CI  - Thieme. All rights reserved.
FAU - Lock, Guntram
AU  - Lock G
AD  - Klinik fur Innere Medizin, Albertinen-Krankenhaus, Hamburg, Germany.
FAU - Oelckers, Michael
AU  - Oelckers M
AD  - Klinik fur Innere Medizin, Albertinen-Krankenhaus, Hamburg, Germany.
FAU - Clauditz, Till Sebastian
AU  - Clauditz TS
AD  - Institut fur Pathologie, Universitatsklinikum Hamburg-Eppendorf, Hamburg, 
      Germany.
FAU - Schrader, Jorg
AU  - Schrader J
AD  - I. Medizinische Klinik und Poliklinik, Universitatsklinikum Hamburg-Eppendorf, 
      Hamburg, Germany.
LA  - eng
PT  - Journal Article
TT  - Neuroendokrine Tumore des Magens: Brauchen wir einen weiteren Subtyp?
DEP - 20210127
PL  - Germany
TA  - Z Gastroenterol
JT  - Zeitschrift fur Gastroenterologie
JID - 0033370
RN  - 0 (Gastrins)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Gastrins
MH  - *Gastroesophageal Reflux
MH  - Humans
MH  - Middle Aged
MH  - *Neuroendocrine Tumors/pathology
MH  - Proton Pump Inhibitors/*adverse effects/therapeutic use
MH  - *Stomach Neoplasms/pathology
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/01/29 06:00
MHDA- 2021/03/13 06:00
CRDT- 2021/01/28 05:47
PHST- 2021/01/29 06:00 [pubmed]
PHST- 2021/03/13 06:00 [medline]
PHST- 2021/01/28 05:47 [entrez]
AID - 10.1055/a-1348-2727 [doi]
PST - ppublish
SO  - Z Gastroenterol. 2021 Mar;59(3):255-258. doi: 10.1055/a-1348-2727. Epub 2021 Jan 
      27.