PMID- 33506527
OWN - NLM
STAT- MEDLINE
DCOM- 20211027
LR  - 20211027
IS  - 1365-2265 (Electronic)
IS  - 0300-0664 (Linking)
VI  - 95
IP  - 3
DP  - 2021 Sep
TI  - Gastric enterochromaffin-like cell changes in multiple endocrine neoplasia type 
      1.
PG  - 439-446
LID - 10.1111/cen.14430 [doi]
AB  - BACKGROUND: Gastric enterochromaffin-like cell (ECL) tumours can occur in 
      patients with multiple endocrine neoplasia type 1 (MEN1), especially in those 
      affected by Zollinger Ellison syndrome (ZES). Since the prevalence of ECL lesions 
      is not well defined yet, the present study evaluated the presence and extent of 
      ECL lesions in MEN1 patients with and without ZES. METHODS: Multiple endocrine 
      neoplasia type 1 patients being part of a regular screening program (2014-2018) 
      underwent gastroduodenoscopies with biopsies of the stomach and determination of 
      serum gastrin and chromogranin A levels. Haematoxylin- and immunostaining with 
      chromogranin A, gastrin and VMAT I and II (vesicular monoamine transporter I and 
      II) of the biopsies were performed. RESULTS: Thirty-eight MEN1 patients, of whom 
      16 (42%) were diagnosed and treated earlier for ZES, were analysed. In ten of 16 
      (62.5%) ZES patients, a locally scattered, mixed image of diffuse, linear and 
      micronodular mild hyperplasia was present. In addition, two of these patients 
      (13%) showed small (max 1.5 mm in size) intramucosal ECL tumours. Neither ECL 
      changes, nor tumours were found in MEN1 patients without ZES (n = 22). In 
      MEN1/ZES patients, the median serum gastrin level was significantly elevated 
      compared to MEN1 patients without ZES (206 pg/ml vs. 30.5 pg/ml, p < .001). A 
      subgroup analysis of the serum gastrin and chromogranin A levels of MEN1/ZES 
      patients with or without ECL hyperplasia did not show significant differences 
      (gastrin level: p = .302, chromogranin A: p = .464). CONCLUSION: 
      Enterochromaffin-like cell hyperplasia and gastric carcinoids occur only in MEN1 
      patients with ZES, but less frequently than reported.
CI  - (c) 2021 The Authors. Clinical Endocrinology published by John Wiley & Sons Ltd.
FAU - Manoharan, Jerena
AU  - Manoharan J
AUID- ORCID: 0000-0003-1611-2712
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipps University 
      Marburg, Marburg, Germany.
FAU - Anlauf, Martin
AU  - Anlauf M
AD  - Institute of Pathology and Cytology, Wetzlar, Germany.
FAU - Albers, Max B
AU  - Albers MB
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipps University 
      Marburg, Marburg, Germany.
FAU - Denzer, Ulrike W
AU  - Denzer UW
AD  - Department of Gastroenterology, Philipps University Marburg, Marburg, Germany.
FAU - Mintziras, Ioannis
AU  - Mintziras I
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipps University 
      Marburg, Marburg, Germany.
FAU - Wachter, Sabine
AU  - Wachter S
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipps University 
      Marburg, Marburg, Germany.
FAU - Di Fazio, Pietro
AU  - Di Fazio P
AUID- ORCID: 0000-0003-0091-8498
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipps University 
      Marburg, Marburg, Germany.
FAU - Bollmann, Carmen
AU  - Bollmann C
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipps University 
      Marburg, Marburg, Germany.
FAU - Bartsch, Detlef K
AU  - Bartsch DK
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipps University 
      Marburg, Marburg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20210207
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 0 (Gastrins)
SB  - IM
MH  - *Carcinoid Tumor
MH  - Enterochromaffin-like Cells
MH  - Gastrins
MH  - Humans
MH  - *Multiple Endocrine Neoplasia Type 1
MH  - *Stomach Neoplasms
MH  - *Zollinger-Ellison Syndrome
OTO - NOTNLM
OT  - ECL hyperplasia
OT  - Zollinger Ellison syndrome
OT  - gastric NEN
OT  - multiple endocrine neoplasia type 1
EDAT- 2021/01/29 06:00
MHDA- 2021/10/28 06:00
CRDT- 2021/01/28 05:48
PHST- 2020/12/08 00:00 [revised]
PHST- 2020/09/30 00:00 [received]
PHST- 2021/01/10 00:00 [accepted]
PHST- 2021/01/29 06:00 [pubmed]
PHST- 2021/10/28 06:00 [medline]
PHST- 2021/01/28 05:48 [entrez]
AID - 10.1111/cen.14430 [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2021 Sep;95(3):439-446. doi: 10.1111/cen.14430. Epub 2021 
      Feb 7.