PMID- 33507111
OWN - NLM
STAT- MEDLINE
DCOM- 20220322
LR  - 20220420
IS  - 1942-7522 (Electronic)
IS  - 0145-5613 (Linking)
VI  - 101
IP  - 2_suppl
DP  - 2022 Feb
TI  - Baicalin Ameliorates Inflammatory Response in a Mouse Model of Rhinosinusitis via 
      Regulating the Treg/Th17 Balance.
PG  - 8S-16S
LID - 10.1177/0145561320986058 [doi]
AB  - OBJECTIVE: Rhinosinusitis is a global health problem affecting millions of people 
      around the world. Baicalin is a bioactive compound isolated from medicinal plant 
      Scutellaria baicalensis Georgi. The present study aims to investigate potential 
      effects of baicalin on clinicopathological changes in nasal/sinus mucosa in a 
      mouse model. METHODS: A mouse model of sinonasal inflammation induced by high 
      dose of ovalbumin was applied to evaluate effects of baicalin. Rhinosinusitis 
      symptoms, histopathological features, levels of histamine, immunoglobulin E 
      (IgE), IL-17A, IL-10, and balance of regulatory T cell (Treg)/T-helper 17 (Th17) 
      responses were examined. RESULTS: Baicalin significantly relieved rhinosinusitis 
      symptoms in mice, reduced histopathological changes, and suppressed serum levels 
      of histamine and IgE in a dose-dependent manner. In lymphocytes of mice, baicalin 
      modulated balance of Treg/Th17 proportions by attenuating Th17 cells and 
      enhancing Treg cells, respectively. The serum IL-17A was decreased and IL-10 was 
      increased in mice treated by baicalin. In addition, baicalin promoted levels of 
      Smad protein 3 (p-Smad3) and forkhead box P3 (FOXP3) to promote Treg cells while 
      suppressed levels of p-Stat3 and retineic-acid-receptor-related orphan nuclear 
      receptor gammat (RORgammat) to inhibit Th17 cells. CONCLUSIONS: These data demonstrate 
      that baicalin effectively ameliorates sinonasal inflammation in a mouse model by 
      recovering the immunological balance of Treg/Th17 responses. Our finding 
      highlights the potential value of baicalin for the treatment of rhinosinusitis.
FAU - Yang, Ming
AU  - Yang M
AD  - Department of Otorhinolaryngology, Nanjing Integrated Traditional Chinese and 
      Western Medicine Hospital, Nanjing, China.
FAU - Zhu, Xiaoyan
AU  - Zhu X
AD  - Department of Otorhinolaryngology, Nanjing Integrated Traditional Chinese and 
      Western Medicine Hospital, Nanjing, China.
FAU - Fu, Feida
AU  - Fu F
AD  - Department of Otorhinolaryngology, Nanjing Integrated Traditional Chinese and 
      Western Medicine Hospital, Nanjing, China.
FAU - Guo, Qinghua
AU  - Guo Q
AD  - Department of Otorhinolaryngology, Nanjing Integrated Traditional Chinese and 
      Western Medicine Hospital, Nanjing, China.
FAU - Zhu, Xiaopu
AU  - Zhu X
AD  - Department of Otorhinolaryngology, Suzhou Integrated Chinese and Western Medicine 
      Hospital, Suzhou, China.
FAU - Xu, Yang
AU  - Xu Y
AD  - Department of Otorhinolaryngology, Wuxi Chinese Medicine Hospital, Wuxi, China.
FAU - Yan, Xiaotian
AU  - Yan X
AD  - Department of Otorhinolaryngology, Changzhou Chinese Medicine Hospital, 
      Changzhou, China.
FAU - He, Xinya
AU  - He X
AD  - Department of Otorhinolaryngology, Nanjing Integrated Traditional Chinese and 
      Western Medicine Hospital, Nanjing, China.
FAU - Wang, Xu
AU  - Wang X
AUID- ORCID: 0000-0001-9141-4206
AD  - Department of Otorhinolaryngology, Nanjing Integrated Traditional Chinese and 
      Western Medicine Hospital, Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20210128
PL  - United States
TA  - Ear Nose Throat J
JT  - Ear, nose, & throat journal
JID - 7701817
RN  - 0 (Flavonoids)
RN  - 347Q89U4M5 (baicalin)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - *Flavonoids/pharmacology
MH  - Humans
MH  - Mice
MH  - *T-Lymphocytes, Regulatory
MH  - Th17 Cells
OTO - NOTNLM
OT  - Th17 cells
OT  - Treg cells
OT  - baicalin
OT  - immunological balance
OT  - rhinosinusitis
EDAT- 2021/01/29 06:00
MHDA- 2022/03/23 06:00
CRDT- 2021/01/28 12:12
PHST- 2021/01/29 06:00 [pubmed]
PHST- 2022/03/23 06:00 [medline]
PHST- 2021/01/28 12:12 [entrez]
AID - 10.1177/0145561320986058 [doi]
PST - ppublish
SO  - Ear Nose Throat J. 2022 Feb;101(2_suppl):8S-16S. doi: 10.1177/0145561320986058. 
      Epub 2021 Jan 28.