PMID- 33509192
OWN - NLM
STAT- MEDLINE
DCOM- 20210524
LR  - 20210524
IS  - 1743-0003 (Electronic)
IS  - 1743-0003 (Linking)
VI  - 18
IP  - 1
DP  - 2021 Jan 28
TI  - Investigating the feasibility of cerebellar transcranial direct current 
      stimulation to facilitate post-stroke overground gait performance in chronic 
      stroke: a partial least-squares regression approach.
PG  - 18
LID - 10.1186/s12984-021-00817-3 [doi]
LID - 18
AB  - BACKGROUND: Investigation of lobule-specific electric field effects of cerebellar 
      transcranial direct current stimulation (ctDCS) on overground gait performance 
      has not been performed, so this study aimed to investigate the feasibility of two 
      lobule-specific bilateral ctDCS montages to facilitate overground walking in 
      chronic stroke. METHODS: Ten chronic post-stroke male subjects participated in 
      this repeated-measure single-blind crossover study, where we evaluated the 
      single-session effects of two bilateral ctDCS montages that applied 2 mA via 3.14 
      cm(2) disc electrodes for 15 min targeting (a) dentate nuclei (also, anterior and 
      posterior lobes), and (b) lower-limb representations (lobules VIIb-IX). A 
      two-sided Wilcoxon rank-sum test was performed at a 5% significance level on the 
      percent normalized change measures in the overground gait performance. Partial 
      least squares regression (PLSR) analysis was performed on the quantitative gait 
      parameters as response variables to the mean lobular electric field strength as 
      the predictors. Clinical assessments were performed with the Ten-Meter walk test 
      (TMWT), Timed Up & Go (TUG), and the Berg Balance Scale based on minimal 
      clinically important differences (MCID). RESULTS: The ctDCS montage specific 
      effect was found significant using a two-sided Wilcoxon rank-sum test at a 5% 
      significance level for 'Step Time Affected Leg' (p = 0.0257) and '%Stance Time 
      Unaffected Leg' (p = 0.0376). The changes in the quantitative gait parameters 
      were found to be correlated to the mean electric field strength in the lobules 
      based on PLSR analysis (R(2) statistic = 0.6574). Here, the mean electric field 
      strength at the cerebellar lobules, Vermis VIIIb, Ipsi-lesional IX, Vermis IX, 
      Ipsi-lesional X, had the most loading and were positively related to the 'Step 
      Time Affected Leg' and '%Stance Time Unaffected Leg,' and negatively related to 
      the '%Swing Time Unaffected Leg,' '%Single Support Time Affected Leg.' Clinical 
      assessments found similar improvement in the TMWT (MCID: 0.10 m/s), TUG (MCID: 
      8 s), and BBS score (MCID: 12.5 points) for both the ctDCS montages. CONCLUSION: 
      Our feasibility study found an association between the lobular mean electric 
      field strength and the changes in the quantitative gait parameters following a 
      single ctDCS session in chronic stroke. Both the ctDCS montages improved the 
      clinical outcome measures that should be investigated with a larger sample size 
      for clinical validation. TRIAL REGISTRATION: Being retrospectively registered.
FAU - Solanki, Dhaval
AU  - Solanki D
AD  - Electrical Engineering, Indian Institute of Technology Gandhinagar, Gujarat, 
      India. dhaval.solanki@iitgn.ac.in.
FAU - Rezaee, Zeynab
AU  - Rezaee Z
AD  - Biomedical Engineering, University at Buffalo SUNY, New York, USA.
FAU - Dutta, Anirban
AU  - Dutta A
AUID- ORCID: 0000-0002-7298-9773
AD  - Biomedical Engineering, University at Buffalo SUNY, New York, USA. 
      anirband@buffalo.edu.
FAU - Lahiri, Uttama
AU  - Lahiri U
AD  - Electrical Engineering, Indian Institute of Technology Gandhinagar, Gujarat, 
      India.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210128
PL  - England
TA  - J Neuroeng Rehabil
JT  - Journal of neuroengineering and rehabilitation
JID - 101232233
SB  - IM
MH  - Cerebellum/*physiopathology
MH  - Cross-Over Studies
MH  - Feasibility Studies
MH  - Gait Disorders, Neurologic/etiology/*rehabilitation
MH  - Humans
MH  - Least-Squares Analysis
MH  - Male
MH  - Middle Aged
MH  - Single-Blind Method
MH  - Stroke/complications
MH  - Stroke Rehabilitation/*methods
MH  - Transcranial Direct Current Stimulation/*methods
PMC - PMC7842063
OTO - NOTNLM
OT  - Cerebellum
OT  - Gait
OT  - Stroke
OT  - Transcranial direct current stimulation
COIS- The authors declare that they have no competing interests.
EDAT- 2021/01/30 06:00
MHDA- 2021/05/25 06:00
PMCR- 2021/01/28
CRDT- 2021/01/29 05:38
PHST- 2020/07/01 00:00 [received]
PHST- 2021/01/12 00:00 [accepted]
PHST- 2021/01/29 05:38 [entrez]
PHST- 2021/01/30 06:00 [pubmed]
PHST- 2021/05/25 06:00 [medline]
PHST- 2021/01/28 00:00 [pmc-release]
AID - 10.1186/s12984-021-00817-3 [pii]
AID - 817 [pii]
AID - 10.1186/s12984-021-00817-3 [doi]
PST - epublish
SO  - J Neuroeng Rehabil. 2021 Jan 28;18(1):18. doi: 10.1186/s12984-021-00817-3.