PMID- 33512036
OWN - NLM
STAT- MEDLINE
DCOM- 20220202
LR  - 20220202
IS  - 1365-2222 (Electronic)
IS  - 0954-7894 (Print)
IS  - 0954-7894 (Linking)
VI  - 51
IP  - 5
DP  - 2021 May
TI  - Allergen skin test reactivity and asthma are inversely associated with ratios of 
      IgG4/IgE and total IgE/allergen-specific IgE in Ugandan communities.
PG  - 703-715
LID - 10.1111/cea.13834 [doi]
AB  - BACKGROUND: Serum inhibition of allergen-specific IgE has been associated with 
      competing IgG4 and non-specific polyclonal IgE. In allergen immunotherapy, 
      beneficial responses have been associated with high IgG4/IgE ratios. Helminths 
      potentiate antibody class switching to IgG4 and stimulate polyclonal IgE 
      synthesis; therefore, we hypothesized a role for helminth-associated IgG4 and 
      total IgE in protection against atopic sensitization and clinical allergy 
      (asthma) in tropical low-income countries. METHODS: Among community residents of 
      Ugandan rural Schistosoma mansoni (Sm)-endemic islands and a mainland urban 
      setting with lower helminth exposure, and among urban asthmatic schoolchildren 
      and non-asthmatic controls, we measured total, Schistosoma adult worm antigen 
      (SWA)-specific, Schistosoma egg antigen (SEA)-specific and allergen (house dust 
      mite [HDM] and German cockroach)-specific IgE and IgG4 by ImmunoCAP((R)) and/or 
      ELISA. We assessed associations between these antibody profiles and current Sm 
      infection, the rural-urban environment, HDM and cockroach skin prick test (SPT) 
      reactivity, and asthma. RESULTS: Total IgE, total IgG4 and SWA-, SEA- and 
      allergen-specific IgE and IgG4 levels were significantly higher in the rural, 
      compared to the urban setting. In both community settings, both Sm infection and 
      SPT reactivity were positively associated with allergen-specific and total IgE 
      responses. SPT reactivity was inversely associated with Schistosoma-specific 
      IgG4, allergen-specific IgG4/IgE ratios and total IgE/allergen-specific IgE 
      ratios. Asthmatic schoolchildren, compared with non-asthmatic controls, had 
      significantly higher levels of total and allergen-specific IgE, but lower ratios 
      of allergen-specific IgG4/IgE and total IgE/allergen-specific IgE. CONCLUSIONS 
      AND CLINICAL RELEVANCE: Our immuno-epidemiological data support the hypothesis 
      that the IgG4-IgE balance and the total IgE-allergen-specific IgE balance are 
      more important than absolute total, helminth- or allergen-specific antibody 
      levels in inhibition of allergies in the tropics.
CI  - (c) 2021 The Authors. Clinical & Experimental Allergy published by John Wiley & 
      Sons Ltd.
FAU - Nkurunungi, Gyaviira
AU  - Nkurunungi G
AUID- ORCID: 0000-0003-4062-9105
AD  - Immunomodulation and Vaccines Programme, Medical Research Council / Uganda Virus 
      Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI 
      and LSHTM) Uganda Research Unit, Entebbe, Uganda.
FAU - Nassuuna, Jacent
AU  - Nassuuna J
AD  - Immunomodulation and Vaccines Programme, Medical Research Council / Uganda Virus 
      Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI 
      and LSHTM) Uganda Research Unit, Entebbe, Uganda.
FAU - Mpairwe, Harriet
AU  - Mpairwe H
AUID- ORCID: 0000-0003-1199-4859
AD  - Immunomodulation and Vaccines Programme, Medical Research Council / Uganda Virus 
      Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI 
      and LSHTM) Uganda Research Unit, Entebbe, Uganda.
AD  - Department of Non-Communicable Disease Epidemiology, London School of Hygiene and 
      Tropical Medicine, London, UK.
FAU - Kabagenyi, Joyce
AU  - Kabagenyi J
AD  - Immunomodulation and Vaccines Programme, Medical Research Council / Uganda Virus 
      Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI 
      and LSHTM) Uganda Research Unit, Entebbe, Uganda.
FAU - Nampijja, Margaret
AU  - Nampijja M
AUID- ORCID: 0000-0002-1200-6042
AD  - Immunomodulation and Vaccines Programme, Medical Research Council / Uganda Virus 
      Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI 
      and LSHTM) Uganda Research Unit, Entebbe, Uganda.
FAU - Sanya, Richard E
AU  - Sanya RE
AUID- ORCID: 0000-0001-6348-9075
AD  - Immunomodulation and Vaccines Programme, Medical Research Council / Uganda Virus 
      Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI 
      and LSHTM) Uganda Research Unit, Entebbe, Uganda.
AD  - College of Health Sciences, Makerere University, Kampala, Uganda.
FAU - Webb, Emily L
AU  - Webb EL
AUID- ORCID: 0000-0002-4019-7456
AD  - MRC Tropical Epidemiology Group, Department of Infectious Disease Epidemiology, 
      London School of Hygiene and Tropical Medicine, London, UK.
FAU - Elliott, Alison M
AU  - Elliott AM
AUID- ORCID: 0000-0003-2818-9549
AD  - Immunomodulation and Vaccines Programme, Medical Research Council / Uganda Virus 
      Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI 
      and LSHTM) Uganda Research Unit, Entebbe, Uganda.
AD  - Department of Clinical Research, London School of Hygiene and Tropical Medicine, 
      London, UK.
LA  - eng
GR  - 102512/Wellcome Trust/United Kingdom
GR  - Medical Research Council (MRC) and the UK Department for International 
      Development (DFID) under the MRC/DFID Concordat agreement/
GR  - 095778/WT_/Wellcome Trust/United Kingdom
GR  - 107743/WT_/Wellcome Trust/United Kingdom
GR  - MC_UU_00027/5/MRC_/Medical Research Council/United Kingdom
GR  - Wellcome Trust/United Kingdom
GR  - 102512/Z/13/Z/WT_/Wellcome Trust/United Kingdom
GR  - African Partnership for Chronic Disease Research/
GR  - MR/R010161/1/MRC_/Medical Research Council/United Kingdom
GR  - 204928/Z/16/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210205
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 0 (Allergens)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Helminth Proteins)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Insect Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/immunology
MH  - Animals
MH  - Antigens, Dermatophagoides/*immunology
MH  - Asthma/epidemiology/*immunology
MH  - Blattellidae
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Helminth Proteins/*immunology
MH  - Humans
MH  - Hypersensitivity/epidemiology/*immunology
MH  - Immunoglobulin E/*immunology
MH  - Immunoglobulin G/*immunology
MH  - Insect Proteins/*immunology
MH  - Male
MH  - Rural Population
MH  - Schistosoma mansoni
MH  - Skin Tests
MH  - Uganda/epidemiology
MH  - Urban Population
PMC - PMC7610822
MID - EMS124574
OTO - NOTNLM
OT  - Schistosoma
OT  - IgE
OT  - IgG4
OT  - allergen
OT  - asthma
OT  - skin prick test
COIS- The authors declare no conflict of interest.
EDAT- 2021/01/30 06:00
MHDA- 2022/02/03 06:00
PMCR- 2021/12/03
CRDT- 2021/01/29 08:38
PHST- 2020/11/12 00:00 [revised]
PHST- 2020/07/15 00:00 [received]
PHST- 2021/01/22 00:00 [accepted]
PHST- 2021/01/30 06:00 [pubmed]
PHST- 2022/02/03 06:00 [medline]
PHST- 2021/01/29 08:38 [entrez]
PHST- 2021/12/03 00:00 [pmc-release]
AID - CEA13834 [pii]
AID - 10.1111/cea.13834 [doi]
PST - ppublish
SO  - Clin Exp Allergy. 2021 May;51(5):703-715. doi: 10.1111/cea.13834. Epub 2021 Feb 
      5.