PMID- 33513426
OWN - NLM
STAT- MEDLINE
DCOM- 20210719
LR  - 20240109
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 174
DP  - 2021 Mar 31
TI  - Comparison of human peripheral blood dendritic cell activation by four fucoidans.
PG  - 477-484
LID - S0141-8130(21)00197-5 [pii]
LID - 10.1016/j.ijbiomac.2021.01.155 [doi]
AB  - Brown seaweed is an important source of fucoidan, which displays immunomodulatory 
      effects by activating various immune cells. However, these effects of fucoidans 
      from various sources of brown seaweed have not yet been explored in human blood 
      dendritic cells. We studied fucoidans extracted from Ecklonia cava, Macrocystis 
      pyrifera, Undaria pinnatifida, and Fucus vesiculosus for their effects on human 
      monocyte-derived dendritic cells (MODC) and human peripheral blood DC (PBDC) 
      activation. Ecklonia cava fucoidan (ECF) strongly upregulated co-stimulatory 
      molecules, major histocompatibility complex class I and II, and the production of 
      proinflammatory cytokines in MODCs and PBDCs compared to those by the other three 
      fucoidans. Moreover, ECF elicited the strongest effect in the induction of 
      syngeneic T cell proliferation and IFN-gamma production compared to those of other 
      fucoidans. These results suggest that ECF could be a suitable candidate molecule 
      for enhancing immune activation in humans compared to that with the other three 
      fucoidans.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan 
      University, Shanghai 201508, China.
FAU - Park, Hae-Bin
AU  - Park HB
AD  - Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan 
      University, Shanghai 201508, China; Department of Medical Biotechnology, Yeungnam 
      University, Gyeongsan 38541, South Korea; Research Institute of Cell Culture, 
      Yeungnam University, Gyeongsan 38541, South Korea.
FAU - Yadav, Dhananjay
AU  - Yadav D
AD  - Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, South 
      Korea.
FAU - Hwang, Juyoung
AU  - Hwang J
AD  - Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan 
      University, Shanghai 201508, China; Department of Medical Biotechnology, Yeungnam 
      University, Gyeongsan 38541, South Korea; Research Institute of Cell Culture, 
      Yeungnam University, Gyeongsan 38541, South Korea.
FAU - An, Eun-Koung
AU  - An EK
AD  - Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, South 
      Korea; Research Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, 
      South Korea.
FAU - Eom, Hee-Yun
AU  - Eom HY
AD  - Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, South 
      Korea.
FAU - Kim, So-Jung
AU  - Kim SJ
AD  - Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, South 
      Korea.
FAU - Kwak, Minseok
AU  - Kwak M
AD  - Department of Chemistry, Pukyong National University, Busan 48513, South Korea.
FAU - Lee, Peter Chang-Whan
AU  - Lee PC
AD  - Department of Biomedical Sciences, University of Ulsan College of Medicine, ASAN 
      Medical Center, Seoul 05505, South Korea. Electronic address: pclee@amc.seoul.kr.
FAU - Jin, Jun-O
AU  - Jin JO
AD  - Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan 
      University, Shanghai 201508, China; Department of Medical Biotechnology, Yeungnam 
      University, Gyeongsan 38541, South Korea; Research Institute of Cell Culture, 
      Yeungnam University, Gyeongsan 38541, South Korea. Electronic address: 
      jinjo@yu.ac.kr.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20210126
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Cytokines)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (IFNG protein, human)
RN  - 0 (Polysaccharides)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9072-19-9 (fucoidan)
SB  - IM
MH  - Cells, Cultured
MH  - Cytokines/metabolism
MH  - Dendritic Cells/cytology/drug effects/*immunology
MH  - Fucus/chemistry
MH  - Gene Expression Regulation/drug effects
MH  - Histocompatibility Antigens Class I/metabolism
MH  - Histocompatibility Antigens Class II/metabolism
MH  - Humans
MH  - Interferon-gamma/metabolism
MH  - Leukocytes, Mononuclear/*cytology/drug effects/immunology
MH  - Macrocystis/chemistry
MH  - Monocytes/*cytology/drug effects/immunology
MH  - Phaeophyceae/chemistry/*classification
MH  - Polysaccharides/chemistry/isolation & purification/*pharmacology
MH  - Seaweed
MH  - T-Lymphocytes/metabolism
MH  - Undaria/chemistry
MH  - Up-Regulation
OTO - NOTNLM
OT  - Adjuvant
OT  - Fucoidans
OT  - Helper T cells
OT  - Human peripheral blood dendritic cells
OT  - Immunity
COIS- Declaration of competing interest The authors declare that they have no competing 
      interests.
EDAT- 2021/01/30 06:00
MHDA- 2021/07/20 06:00
CRDT- 2021/01/29 20:06
PHST- 2020/11/11 00:00 [received]
PHST- 2021/01/13 00:00 [revised]
PHST- 2021/01/23 00:00 [accepted]
PHST- 2021/01/30 06:00 [pubmed]
PHST- 2021/07/20 06:00 [medline]
PHST- 2021/01/29 20:06 [entrez]
AID - S0141-8130(21)00197-5 [pii]
AID - 10.1016/j.ijbiomac.2021.01.155 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2021 Mar 31;174:477-484. doi: 
      10.1016/j.ijbiomac.2021.01.155. Epub 2021 Jan 26.