PMID- 3351423
OWN - NLM
STAT- MEDLINE
DCOM- 19880502
LR  - 20190709
IS  - 0022-0795 (Print)
IS  - 0022-0795 (Linking)
VI  - 116
IP  - 2
DP  - 1988 Feb
TI  - Potentiation of lactation-induced oxytocin secretion by intracerebroventricular 
      oxytocin in the conscious goat.
PG  - 273-7
AB  - The release of oxytocin into the cerebrospinal fluid (CSF) and plasma of 
      lactating goats was studied following implantation of cisternal and lateral 
      ventricular cannulae. Hand milking was associated with a significant increase in 
      plasma concentrations of oxytocin, but no change in plasma concentrations of 
      vasopressin or CSF concentrations of oxytocin. Intracerebroventricular (i.c.v.) 
      infusion of oxytocin itself (1 pmol/min for 60 min) had no effect on basal plasma 
      levels of oxytocin. It did, however, markedly potentiate the milking-induced 
      increase in plasma oxytocin above the levels achieved during i.c.v. infusion of 
      artificial CSF alone. In the goat, therefore, milking results in a selective 
      release of oxytocin into the plasma, and this release can be potentiated by the 
      presence of increased concentrations of oxytocin in the CSF.
FAU - Seckl, J R
AU  - Seckl JR
AD  - Department of Medicine, Charing Cross and Westminster Medical School, Westminster 
      Hospital, London.
FAU - Lightman, S L
AU  - Lightman SL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Endocrinol
JT  - The Journal of endocrinology
JID - 0375363
RN  - 11000-17-2 (Vasopressins)
RN  - 50-56-6 (Oxytocin)
SB  - IM
MH  - Animals
MH  - Drug Synergism
MH  - Female
MH  - Goats
MH  - Injections, Intraventricular
MH  - Lactation/*metabolism
MH  - Oxytocin/blood/metabolism/*pharmacology
MH  - Pregnancy
MH  - Vasopressins/blood
EDAT- 1988/02/01 00:00
MHDA- 1988/02/01 00:01
CRDT- 1988/02/01 00:00
PHST- 1988/02/01 00:00 [pubmed]
PHST- 1988/02/01 00:01 [medline]
PHST- 1988/02/01 00:00 [entrez]
AID - 10.1677/joe.0.1160273 [doi]
PST - ppublish
SO  - J Endocrinol. 1988 Feb;116(2):273-7. doi: 10.1677/joe.0.1160273.