PMID- 33514457
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20210818
IS  - 1773-0597 (Electronic)
IS  - 0181-5512 (Linking)
VI  - 44
IP  - 3
DP  - 2021 Mar
TI  - Functional Prognostic value of optical coherence tomography in optic chiasmal 
      decompression: A preliminary study.
PG  - 321-330
LID - S0181-5512(21)00027-9 [pii]
LID - 10.1016/j.jfo.2020.06.041 [doi]
AB  - PURPOSE: To assess the predictive value for functional recovery of Ganglion Cell 
      Complex Layer (GCC) and Retinal Nerve Fiber Layer (RNFL) measurements obtained by 
      Optical Coherence Tomography (OCT) in patients undergoing chiasmal decompression 
      and to define potential OCT thresholds for visual recovery. METHODS: We measured 
      preoperative GCC and RNFL thickness in patients with a sellar and/or perisellar 
      tumor compressing the optic chiasm. Visual recovery was defined as recovery of 
      mean deviation (MD) and pattern standard deviation (PSD) using Humphrey visual 
      field testing after 12 successful decompressions (24 eyes). Receiver operating 
      characteristic curve (ROC) analysis was used to identify the best thresholds. 
      RESULTS: Robust global and focal OCT thresholds were found. Superior GCC>/=63mum had 
      the best functional prognostic value (AUC=1) for visual improvement. Mean GCC >/= 
      67mum and mean RNFL>/=75mum also had excellent predictive values (AUC>0.9). 
      CONCLUSION: In this preliminary study, significant preoperative OCT thresholds 
      for early visual recovery after chiasmal decompression were identified, mainly 
      regarding GCC measurements. Further studies on larger cohorts with closely 
      scheduled follow-up could refine our results.
CI  - Copyright (c) 2021 Elsevier Masson SAS. All rights reserved.
FAU - Mambour, N
AU  - Mambour N
AD  - Cliniques universitaires Saint-Luc, UC Louvain, 10, avenue Hippocrate, Brussels, 
      Belgium. Electronic address: natasha.mambour@gmail.com.
FAU - Maiter, D
AU  - Maiter D
AD  - Cliniques universitaires Saint-Luc, UC Louvain, 10, avenue Hippocrate, Brussels, 
      Belgium.
FAU - Duprez, T
AU  - Duprez T
AD  - Cliniques universitaires Saint-Luc, UC Louvain, 10, avenue Hippocrate, Brussels, 
      Belgium.
FAU - Costa, E
AU  - Costa E
AD  - Cliniques universitaires Saint-Luc, UC Louvain, 10, avenue Hippocrate, Brussels, 
      Belgium.
FAU - Fomekong, E
AU  - Fomekong E
AD  - Cliniques universitaires Saint-Luc, UC Louvain, 10, avenue Hippocrate, Brussels, 
      Belgium.
FAU - Raftopoulos, C
AU  - Raftopoulos C
AD  - Cliniques universitaires Saint-Luc, UC Louvain, 10, avenue Hippocrate, Brussels, 
      Belgium.
FAU - Bugli, C
AU  - Bugli C
AD  - Plateforme technologique de support en methodologie et calcul statistique, 20, 
      voie du Roman-Pays, Louvain-La-Neuve, Belgium.
FAU - Boschi, A
AU  - Boschi A
AD  - Cliniques universitaires Saint-Luc, UC Louvain, 10, avenue Hippocrate, Brussels, 
      Belgium.
LA  - eng
PT  - Journal Article
DEP - 20210126
PL  - France
TA  - J Fr Ophtalmol
JT  - Journal francais d'ophtalmologie
JID - 7804128
SB  - IM
MH  - Decompression
MH  - Humans
MH  - Nerve Fibers
MH  - *Optic Chiasm/diagnostic imaging
MH  - Prognosis
MH  - ROC Curve
MH  - Retinal Ganglion Cells
MH  - *Tomography, Optical Coherence
MH  - Visual Fields
OTO - NOTNLM
OT  - Chiasmal compression
OT  - Compression chiasmatique
OT  - Functional predictive value
OT  - Ganglion Cell Complex
OT  - Optical coherence tomography
OT  - Recuperation visuelle
OT  - Seuil
OT  - Threshold
OT  - Valeur predictive fonctionnelle
OT  - Visual recovery
EDAT- 2021/01/31 06:00
MHDA- 2021/08/19 06:00
CRDT- 2021/01/30 05:24
PHST- 2020/04/11 00:00 [received]
PHST- 2020/06/07 00:00 [revised]
PHST- 2020/06/18 00:00 [accepted]
PHST- 2021/01/31 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2021/01/30 05:24 [entrez]
AID - S0181-5512(21)00027-9 [pii]
AID - 10.1016/j.jfo.2020.06.041 [doi]
PST - ppublish
SO  - J Fr Ophtalmol. 2021 Mar;44(3):321-330. doi: 10.1016/j.jfo.2020.06.041. Epub 2021 
      Jan 26.