PMID- 33515106
OWN - NLM
STAT- MEDLINE
DCOM- 20210723
LR  - 20210723
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Linking)
VI  - 29
IP  - 8
DP  - 2021 Aug
TI  - Associations between baseline demographic, clinical and lifestyle factors, and 
      changes in fatigue, depression, and health-related quality of life in long-term 
      cancer survivors: a cohort study.
PG  - 4711-4722
LID - 10.1007/s00520-021-06015-0 [doi]
AB  - PURPOSE: To investigate the longitudinal associations between demographic, 
      clinical and lifestyle factors, and changes in patient-reported outcomes (PROs) 
      in cancer survivors 6-9 years post-diagnosis in Western Australia. METHODS: A 
      total of 290 individuals participated in this study. Three-quarters of 
      participants were female, and 55%, 31%, and 14% were survivors of breast cancer, 
      colon cancer, and non-Hodgkin lymphoma (NHL), respectively. PROs (fatigue, 
      depression, and health-related quality of life (HRQOL)) were reported at two time 
      points (2012-13 and 2017). Descriptive statistics were used to assess the overall 
      changes over time and linear mixed models were used to identify factors 
      associated with changes over time, after adjusting for confounders. RESULTS: No 
      significant changes were observed in PROs between time point 1 and follow-up at 
      the population level, yet a notable proportion of participants (23% for fatigue, 
      10% for depression, and 39% for HRQOL) reported a negative minimal clinically 
      important difference (MCID). Being non-Caucasian and having had NHL were 
      associated with negative changes over time. Being obese and having had 
      radiotherapy were related to improved outcomes. CONCLUSION: Cancer survivors 
      whose levels of fatigue, depression, and quality of life are compromised during 
      cancer treatment may require intervention even 6-9 years post-treatment. Our 
      results suggest particular attention should be paid to those who are 
      non-Caucasian and who have had NHL. This is crucial for providing appropriate 
      care and to support those who are at increased risk of deteriorating naturally 
      over time.
FAU - van der Kruk, Shannen R
AU  - van der Kruk SR
AD  - Department of Epidemiology, Maastricht University, Maastricht, the Netherlands.
AD  - Australian Centre for Precision Health, University of South Australia, Adelaide, 
      SA, Australia.
AD  - Cancer Research Institute, University of South Australia, Adelaide, SA, 
      Australia.
FAU - Gunn, Kate M
AU  - Gunn KM
AD  - Cancer Research Institute, University of South Australia, Adelaide, SA, 
      Australia.
AD  - Department of Rural Health, University of South Australia, Adelaide, SA, 
      Australia.
FAU - Mesters, Ilse
AU  - Mesters I
AD  - Department of Epidemiology, Maastricht University, Maastricht, the Netherlands.
FAU - Lynch, Brigid M
AU  - Lynch BM
AD  - Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
AD  - Melbourne School of Population and Global Health, University of Melbourne, 
      Melbourne, VIC, Australia.
AD  - Baker Heart and Diabetes Institute, Physical Activity Laboratory, Melbourne, VIC, 
      Australia.
FAU - Vallance, Jeff K
AU  - Vallance JK
AD  - Faculty of Health Disciplines, Athabasca University, Athabasca, AB, Canada.
FAU - Boyle, Terry
AU  - Boyle T
AUID- ORCID: 0000-0001-6741-330X
AD  - Australian Centre for Precision Health, University of South Australia, Adelaide, 
      SA, Australia. Terry.Boyle@unisa.edu.au.
AD  - Cancer Research Institute, University of South Australia, Adelaide, SA, 
      Australia. Terry.Boyle@unisa.edu.au.
AD  - Allied Health and Human Performance, University of South Australia, Adelaide, SA, 
      Australia. Terry.Boyle@unisa.edu.au.
AD  - School of Public Health, Curtin University, Perth, WA, Australia. 
      Terry.Boyle@unisa.edu.au.
LA  - eng
GR  - MCRF18005/Victorian Cancer Agency/
PT  - Journal Article
DEP - 20210129
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cancer Survivors/*psychology
MH  - Cohort Studies
MH  - Depression/*etiology
MH  - Fatigue/*etiology
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Quality of Life/*psychology
MH  - Young Adult
OTO - NOTNLM
OT  - Cancer
OT  - Depression
OT  - Fatigue
OT  - Oncology
OT  - Quality of life
OT  - Survivor
EDAT- 2021/01/31 06:00
MHDA- 2021/07/24 06:00
CRDT- 2021/01/30 05:35
PHST- 2020/09/29 00:00 [received]
PHST- 2021/01/19 00:00 [accepted]
PHST- 2021/01/31 06:00 [pubmed]
PHST- 2021/07/24 06:00 [medline]
PHST- 2021/01/30 05:35 [entrez]
AID - 10.1007/s00520-021-06015-0 [pii]
AID - 10.1007/s00520-021-06015-0 [doi]
PST - ppublish
SO  - Support Care Cancer. 2021 Aug;29(8):4711-4722. doi: 10.1007/s00520-021-06015-0. 
      Epub 2021 Jan 29.