PMID- 33515717 OWN - NLM STAT- MEDLINE DCOM- 20211209 LR - 20211214 IS - 1878-1780 (Electronic) IS - 1262-3636 (Linking) VI - 47 IP - 5 DP - 2021 Sep TI - Exposure to persistent organic pollutants and the risk of type 2 diabetes: a case-cohort study. PG - 101234 LID - S1262-3636(21)00017-3 [pii] LID - 10.1016/j.diabet.2021.101234 [doi] AB - AIMS: To explore exposure to 22 persistent organic pollutants (POPs) and incident type 2 diabetes in a population-based, prospective cohort. METHODS: This case-cohort study on 753 participants without type 2 diabetes at baseline, was followed-up over nine years, as part of the French D.E.S.I.R. cohort. We measured 22 POPs in fasting serum at baseline. The associations between baseline POP concentrations, pre-adjusted for lipids, BMI, age and sex, with incident type 2 diabetes, were assessed using Prentice-weighted Cox regression models (time scale: age), adjusted for traditional confounding factors. POPs were also modelled summed in functional groups: polychlorinated biphenyls ( summation operatorPCB) and organochlorines ( summation operatorOC) and also individually, after log-transformation, in adjusted Cox models. RESULTS: There were 200 incident diabetes cases over nine years. Pre-adjusted POP concentrations were not related to diabetes risk for any of the 22 POPs examined. The fully-adjusted hazard ratios (HRs) per interquartile range of the pre-adjusted POPs, ranged from 0.87 (95% CI: 0.64,1.19) to 1.22 (0.93,1.59,). For dichlorodiphenyldichloroethylene (p, p'-DDE) and dichlorodiphenyltrichloroethane (p, p'-DDT), the HRs were 1.09 (0.83,1.43) and 0.89 (0.70,1.13), respectively. The HRs for PeCB, HCB, beta-HCH, gamma-HCH, oxychlordane, trans-nonachlor were 0.98 (0.85,1.13), 1.06 (0.84,1.33), 1.22 (0.93,1.59), 1.13 (0.89,1.42), 1.00 (0.76,1.31), 0.86 (0.66,1.13), respectively. HRs for summation operatorPCB, summation operatorOC and for individual log-transformed POPs did not differ significantly from one. CONCLUSION: We did not observe any relations between exposure to POPs and diabetes in this population-based cohort. These results do not support causal inferences reported in previous studies linking serum POP concentrations and diabetes risk. CI - Copyright (c) 2021 Elsevier Masson SAS. All rights reserved. FAU - Magliano, Dianna J AU - Magliano DJ AD - Baker Heart and Diabetes Institute, Diabetes and Population Health, Melbourne, Australia; Monash University, Department of Epidemiology and Preventive Medicine, Melbourne, Australia. Electronic address: dianna.magliano@baker.edu.au. FAU - Ranciere, Fanny AU - Ranciere F AD - Universite de Paris, Centre of Research in Epidemiology and Statistics (CRESS), Inserm, F-75004 Paris, France; Universite de Paris, Faculte de Pharmacie de Paris, Paris, France. FAU - Slama, Remy AU - Slama R AD - Inserm-Centre National de la Recherche Scientifique (CNRS) and Universite Grenoble-Alpes Joint Research Center, Institute for Advanced Biosciences (IAB), U1209, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France; Universite Grenoble-Alpes, IAB, Grenoble, France. FAU - Roussel, Ronan AU - Roussel R AD - Inserm, UMRS 1138, Centre de Recherche des Cordeliers, Paris, France; Assistance Publique-Hopitaux de Paris, Bichat Hospital, DHU FIRE, Diabetology, Endocrinology and Nutrition, Paris, France; Universite de Paris, UFR de Medecine, Paris, France. FAU - Kiviranta, Hannu AU - Kiviranta H AD - National Institute of Health and Welfare, Kuopio, Finland. FAU - Coumoul, Xavier AU - Coumoul X AD - Universite de Paris, T3S, Inserm UMR S-1124, F-75006 Paris, France. FAU - Balkau, Beverley AU - Balkau B AD - Universite Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Clinical Epidemiology, CESP, Villejuif, France. FAU - Botton, Jeremie AU - Botton J AD - EPI-PHARE Scientific Interest Group in Epidemiology of Health Products, French National Agency for the Safety of Medicines and Health Products and the French National Health Insurance, Saint-Denis, Ile-de-France, France; IRSA, La Riche, France. CN - D.E.S.I.R. Study Group LA - eng PT - Journal Article DEP - 20210127 PL - France TA - Diabetes Metab JT - Diabetes & metabolism JID - 9607599 RN - 0 (Environmental Pollutants) RN - 0 (Hydrocarbons, Chlorinated) RN - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Cohort Studies MH - *Diabetes Mellitus, Type 2/chemically induced/epidemiology MH - Dichlorodiphenyl Dichloroethylene MH - Environmental Exposure/statistics & numerical data MH - *Environmental Pollutants MH - Humans MH - *Hydrocarbons, Chlorinated MH - Persistent Organic Pollutants MH - *Polychlorinated Biphenyls/analysis MH - Prospective Studies OTO - NOTNLM OT - Diabetes mellitus OT - Incidence OT - Organic pollutants OT - Organochlorine insecticides OT - Persistent OT - Pesticides OT - Polybrominated biphenyls EDAT- 2021/01/31 06:00 MHDA- 2021/12/15 06:00 CRDT- 2021/01/30 20:09 PHST- 2020/11/01 00:00 [received] PHST- 2021/01/06 00:00 [revised] PHST- 2021/01/09 00:00 [accepted] PHST- 2021/01/31 06:00 [pubmed] PHST- 2021/12/15 06:00 [medline] PHST- 2021/01/30 20:09 [entrez] AID - S1262-3636(21)00017-3 [pii] AID - 10.1016/j.diabet.2021.101234 [doi] PST - ppublish SO - Diabetes Metab. 2021 Sep;47(5):101234. doi: 10.1016/j.diabet.2021.101234. Epub 2021 Jan 27.