PMID- 33515890
OWN - NLM
STAT- MEDLINE
DCOM- 20210318
LR  - 20210318
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 770
DP  - 2021 May 20
TI  - Prenatal exposure to organochlorine pesticides is associated with increased risk 
      for neural tube defects.
PG  - 145284
LID - S0048-9697(21)00350-8 [pii]
LID - 10.1016/j.scitotenv.2021.145284 [doi]
AB  - Neural tube defects (NTDs) are among the most common and disabling fetal 
      congenital defects. Organochlorine pesticides (OCPs) are ubiquitous in the 
      environment. In this study, 119 women who had NTD-affected pregnancies (cases) 
      and 119 women who delivered healthy neonates (controls) were recruited in a rural 
      area of Northern China. We used concentrations of OCPs in umbilical cord tissue 
      as markers of prenatal exposure to investigate the association between in utero 
      exposure to OCPs and NTD risk. Concentrations of 20 OCPs were quantified by gas 
      chromatography-mass spectrometry, and 16 of the 20 OCPs were included in the 
      analyses. Odds ratios and 95% confidence intervals (95% CIs) for the associations 
      between levels of individual OCPs and NTD risk were estimated separately with 
      logistic regression adjusting for potential confounders. The combined effects of 
      exposure to the 16 OCPs as a mixture were analyzed with Bayesian kernel machine 
      regression (BKMR). Logistic regression showed that the risk for NTDs increased 
      5.44-fold (95% CI, 2.21-13.41) for beta-hexachlorocyclohexane, 2.51-fold (95% CI, 
      1.07-5.86) for endosulfan I, 3.78-fold (95% CI, 1.60-8.89) for endosulfan II, 
      3.42-fold (95% CI, 1.44-8.12) for omicron,rho'-dichlorodiphenyldichloroethane, and 
      2.89-fold (95% CI, 1.22-6.86) for rho,rho'-dichlorodiphenyltrichloroethane when the 
      concentration of each of these OCPs was above its median (exposed) compared to 
      below its median (non-exposed). Other OCPs were not associated with NTD risk in 
      multivariate models. In BKMR, NTD risk increased almost linearly with 
      concentrations of the 16 OCPs as a mixture, which suggests joint effects on NTD 
      risk. Exposure to alpha-hexachlorocyclohexane, beta-hexachlorocyclohexane, endosulfan 
      II, omicron,rho'-dichlorodiphenyldichloroethane, and rho,rho'-dichlorodiphenyldichloroethane 
      was associated with an increased risk for NTDs when levels of the remaining 15 
      OCPs were taken into account. Taken together, these findings show that prenatal 
      exposure to OCPs is associated with increased risk for NTDs.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Yin, Shengju
AU  - Yin S
AD  - Department of Pharmacology, School of Basic Medical Sciences, Peking University, 
      Beijing, China; Institute of Reproductive and Child Health, National Health 
      Commission Key Laboratory of Reproductive Health, Peking University, Beijing, 
      China.
FAU - Sun, Ying
AU  - Sun Y
AD  - Institute of Reproductive and Child Health, National Health Commission Key 
      Laboratory of Reproductive Health, Peking University, Beijing, China; Department 
      of Epidemiology and Biostatistics, School of Public Health, Peking University, 
      Beijing, China.
FAU - Yu, Jinhui
AU  - Yu J
AD  - Institute of Reproductive and Child Health, National Health Commission Key 
      Laboratory of Reproductive Health, Peking University, Beijing, China; Department 
      of Epidemiology and Biostatistics, School of Public Health, Peking University, 
      Beijing, China.
FAU - Su, Zaiming
AU  - Su Z
AD  - Institute of Reproductive and Child Health, National Health Commission Key 
      Laboratory of Reproductive Health, Peking University, Beijing, China; Department 
      of Epidemiology and Biostatistics, School of Public Health, Peking University, 
      Beijing, China.
FAU - Tong, Mingkun
AU  - Tong M
AD  - Institute of Reproductive and Child Health, National Health Commission Key 
      Laboratory of Reproductive Health, Peking University, Beijing, China; Department 
      of Epidemiology and Biostatistics, School of Public Health, Peking University, 
      Beijing, China.
FAU - Zhang, Yali
AU  - Zhang Y
AD  - Institute of Reproductive and Child Health, National Health Commission Key 
      Laboratory of Reproductive Health, Peking University, Beijing, China; Department 
      of Epidemiology and Biostatistics, School of Public Health, Peking University, 
      Beijing, China.
FAU - Liu, Jufen
AU  - Liu J
AD  - Institute of Reproductive and Child Health, National Health Commission Key 
      Laboratory of Reproductive Health, Peking University, Beijing, China; Department 
      of Epidemiology and Biostatistics, School of Public Health, Peking University, 
      Beijing, China.
FAU - Wang, Linlin
AU  - Wang L
AD  - Institute of Reproductive and Child Health, National Health Commission Key 
      Laboratory of Reproductive Health, Peking University, Beijing, China; Department 
      of Epidemiology and Biostatistics, School of Public Health, Peking University, 
      Beijing, China.
FAU - Li, Zhiwen
AU  - Li Z
AD  - Institute of Reproductive and Child Health, National Health Commission Key 
      Laboratory of Reproductive Health, Peking University, Beijing, China; Department 
      of Epidemiology and Biostatistics, School of Public Health, Peking University, 
      Beijing, China.
FAU - Ren, Aiguo
AU  - Ren A
AD  - Institute of Reproductive and Child Health, National Health Commission Key 
      Laboratory of Reproductive Health, Peking University, Beijing, China; Department 
      of Epidemiology and Biostatistics, School of Public Health, Peking University, 
      Beijing, China. Electronic address: renag@bjmu.edu.cn.
FAU - Jin, Lei
AU  - Jin L
AD  - Institute of Reproductive and Child Health, National Health Commission Key 
      Laboratory of Reproductive Health, Peking University, Beijing, China; Department 
      of Epidemiology and Biostatistics, School of Public Health, Peking University, 
      Beijing, China. Electronic address: jinlei@bjmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210122
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
SB  - IM
MH  - Bayes Theorem
MH  - China/epidemiology
MH  - Female
MH  - Humans
MH  - *Hydrocarbons, Chlorinated/analysis
MH  - Infant, Newborn
MH  - *Neural Tube Defects/chemically induced/epidemiology
MH  - *Pesticides
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Joint effects
OT  - Neural tube defects
OT  - Organochlorine pesticides
OT  - Umbilical cord tissue
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/01/31 06:00
MHDA- 2021/03/19 06:00
CRDT- 2021/01/30 20:11
PHST- 2020/11/22 00:00 [received]
PHST- 2021/01/14 00:00 [revised]
PHST- 2021/01/14 00:00 [accepted]
PHST- 2021/01/31 06:00 [pubmed]
PHST- 2021/03/19 06:00 [medline]
PHST- 2021/01/30 20:11 [entrez]
AID - S0048-9697(21)00350-8 [pii]
AID - 10.1016/j.scitotenv.2021.145284 [doi]
PST - ppublish
SO  - Sci Total Environ. 2021 May 20;770:145284. doi: 10.1016/j.scitotenv.2021.145284. 
      Epub 2021 Jan 22.