PMID- 33517531 OWN - NLM STAT- MEDLINE DCOM- 20210603 LR - 20210603 IS - 1614-7499 (Electronic) IS - 0944-1344 (Linking) VI - 28 IP - 22 DP - 2021 Jun TI - Increased urinary arsenic concentration in newly diagnosed type 2 diabetes mellitus: a gender-independent, smoking-dependent exposure biomarker in older adults in Tehran. PG - 27769-27777 LID - 10.1007/s11356-020-10261-w [doi] AB - Arsenic is ranked in the top ten environmental toxicants but its impact on type 2 diabetes mellitus (T2DM) and its association with other human health effects is contradictory. We aimed in this study to compare the urinary arsenic concentration (u As) in older age adults (> 40 years) and their T2DM subgroup in an age and gender-matched case control study to find the association of u As with, diet, oxidative stress, smoking, anthropometric factors, and lifestyle in our study participants. Face-to-face interviews based on structured questionnaires were conducted on 200 female and male volunteers (100 cases and 100 control). Considering the exclusion criteria, u As concentration and serum biomarkers of oxidative stress (malondialdehyde, superoxide dismutase, catalase) of 30 newly diagnosed T2DM and 30 control were determined by ICP-mass analysis and ELISA reader respectively. Despite the similarities in sociodemographic, diet, and lifestyle factors in males and females and their T2DM subgroups, a 4 times difference in u As levels between T2DM (93.7 ng/L (32)) and their healthy counterparts (23.7 ng/L (2.3)) without meaningful associations with gender, age, BMI, diet, and lifestyle was observed. Mean u As concentration in total population of smokers was significantly higher than non-smokers ((119 ng/L vs. 22.5 ng/L (p = 0.03)) and oxidative stress markers were not significantly higher in T2DM smokers than non-smokers. Chronic arsenic exposure through smoking could be contributed to the incidence of T2DM in older age adults. Oxidative stress markers were not significantly increased in smoker subgroup compared with non-smokers but except smoking pattern, other variables did not affect u As concentration. Precautionary measure to reduce the exposure of people with this element is recommended to prevent the arsenic-induced T2DM in human populations. FAU - Arab YarMohammadi, Atena AU - Arab YarMohammadi A AD - Pharmaceutical Sciences Research Center, Islamic Azad University, Tehran Medical Sciences University (IAUTMU), Tehran, Iran. FAU - Arbabi Bidgoli, Sepideh AU - Arbabi Bidgoli S AUID- ORCID: 0000-0003-4830-8680 AD - Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Islamic Azad University, Tehran Medical Sciences University (IAUTMU), Dr. Shariati St., Gholhak, Yakhchal, Pharmaceutical Science Branch, Tehran, Iran. sepideharbabi@yahoo.com. FAU - Ziarati, Parisa AU - Ziarati P AD - Nutrition and Food Sciences Research Center, Faculty of Pharmacy and Pharmaceutical Sciences, Islamic Azad University, Tehran Medical Sciences University (IAUTMU), Tehran, Iran. LA - eng PT - Journal Article DEP - 20210130 PL - Germany TA - Environ Sci Pollut Res Int JT - Environmental science and pollution research international JID - 9441769 RN - 0 (Biomarkers) RN - N712M78A8G (Arsenic) SB - IM MH - Aged MH - *Arsenic MH - Biomarkers MH - Case-Control Studies MH - *Diabetes Mellitus, Type 2 MH - Female MH - Humans MH - Iran MH - Male MH - Smoking OTO - NOTNLM OT - Arsenic OT - Diet OT - Lifestyle OT - T2DM OT - Type II diabetes mellitus EDAT- 2021/02/01 06:00 MHDA- 2021/06/04 06:00 CRDT- 2021/01/31 20:40 PHST- 2020/04/14 00:00 [received] PHST- 2020/07/22 00:00 [accepted] PHST- 2021/02/01 06:00 [pubmed] PHST- 2021/06/04 06:00 [medline] PHST- 2021/01/31 20:40 [entrez] AID - 10.1007/s11356-020-10261-w [pii] AID - 10.1007/s11356-020-10261-w [doi] PST - ppublish SO - Environ Sci Pollut Res Int. 2021 Jun;28(22):27769-27777. doi: 10.1007/s11356-020-10261-w. Epub 2021 Jan 30.