PMID- 33518553
OWN - NLM
STAT- MEDLINE
DCOM- 20220316
LR  - 20220716
IS  - 1880-3873 (Electronic)
IS  - 1340-3478 (Print)
IS  - 1340-3478 (Linking)
VI  - 29
IP  - 2
DP  - 2022 Feb 1
TI  - Clinical Impact of Measures for Frailty Severity in Poor-Risk Patients Undergoing 
      Revascularization for Chronic Limb-Threatening Ischemia.
PG  - 221-228
LID - 10.5551/jat.61481 [doi]
AB  - AIM: This study aimed to demonstrate the clinical impact of various 
      frailty-related aspects in poor-risk patients undergoing revascularization for 
      chronic limb-threatening ischemia (CLTI). METHODS: We analyzed a clinical 
      database of a prospective multicenter observational study. A total of 562 CLTI 
      patients who required assistance for their daily lives and were candidates for 
      revascularization were included. We examined various measures of frailty 
      severity, including activities of daily living (ADL)/mobility, physical 
      performance, nutritional status, cognitive function, and cardiac function at 
      baseline (before revascularization). Data on inflammatory markers at baseline and 
      ADL/mobility before CLTI onset were also collected. RESULTS: The patients were 
      aged 77+/-10 years, 65% were non-ambulatory, and 38% were categorized as mild 
      dementia or severer. The correlation coefficients between the frailty measures 
      ranged from 0.00 to 0.91. The random forest analysis for one-year mortality risk 
      showed that these frailty-related measures, as well as age and inflammatory 
      markers, had a relatively high variable importance compared with comorbidities 
      and limb severity. CONCLUSION: The correlations between measures of frailty 
      severity were not always strong but rather widely varied in CLTI patients who 
      required assistance for their daily lives and were candidates for 
      revascularization. Measures of frailty severity, as well as age and inflammatory 
      markers, had a relatively large predictive impact on one-year mortality risk 
      compared with comorbidities and limb severity in the population.
FAU - Takahara, Mitsuyoshi
AU  - Takahara M
AD  - Department of Diabetes Care Medicine, and Department of Metabolic Medicine, Osaka 
      University Graduate School of Medicine.
FAU - Iida, Osamu
AU  - Iida O
AD  - Cardiovascular Center, Kansai Rosai Hospital.
FAU - Soga, Yoshimitsu
AU  - Soga Y
AD  - Department of Cardiology, Kokura Memorial Hospital.
FAU - Azuma, Nobuyoshi
AU  - Azuma N
AD  - Department of Vascular Surgery, Asahikawa Medical University.
FAU - Nanto, Shinsuke
AU  - Nanto S
AD  - Department of Cardiology, Nishinomiya Municipal Central Hospital.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
DEP - 20210130
PL  - Japan
TA  - J Atheroscler Thromb
JT  - Journal of atherosclerosis and thrombosis
JID - 9506298
SB  - IM
MH  - Activities of Daily Living
MH  - Aged
MH  - Aged, 80 and over
MH  - Chronic Limb-Threatening Ischemia/complications/*surgery
MH  - Cohort Studies
MH  - Female
MH  - Frailty/*complications/*diagnosis
MH  - Humans
MH  - Japan
MH  - *Limb Salvage
MH  - Male
MH  - Patient Selection
MH  - Predictive Value of Tests
MH  - *Severity of Illness Index
MH  - Treatment Outcome
PMC - PMC8803558
OTO - NOTNLM
OT  - Chronic limb-threatening ischemia
OT  - Correlation
OT  - Frailty
OT  - Revascularization
EDAT- 2021/02/02 06:00
MHDA- 2022/03/17 06:00
PMCR- 2022/02/01
CRDT- 2021/02/01 05:49
PHST- 2021/02/02 06:00 [pubmed]
PHST- 2022/03/17 06:00 [medline]
PHST- 2021/02/01 05:49 [entrez]
PHST- 2022/02/01 00:00 [pmc-release]
AID - DN/JST.JSTAGE/jat/61481 [pii]
AID - 10.5551/jat.61481 [doi]
PST - ppublish
SO  - J Atheroscler Thromb. 2022 Feb 1;29(2):221-228. doi: 10.5551/jat.61481. Epub 2021 
      Jan 30.