PMID- 33519555
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210202
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 11
DP  - 2020
TI  - Does Hippocampal Volume Predict Transition to Psychosis in a High-Risk Group? A 
      Meta-Analysis.
PG  - 614659
LID - 10.3389/fpsyt.2020.614659 [doi]
LID - 614659
AB  - Schizophrenia has a prodromal phase of several years in most patients, making it 
      possible to identify patients at clinical high risk (CHR) for developing the 
      disorder. So far, these individuals are identified based on clinical criteria 
      alone, and there is no reliable biomarker for predicting the transition to 
      psychosis. It is well-established that reductions in brain volume, especially in 
      the hippocampus, are associated with schizophrenia. Therefore, hippocampal volume 
      may serve as a biomarker for psychosis. Several studies have already investigated 
      hippocampal volume in CHR groups. Based on these studies, the present 
      meta-analysis compares the baseline left and right hippocampal volume of CHR 
      patients who developed a psychosis with that of CHR patients without such a 
      transition. Our results show no statistically significant effect of the 
      hippocampal volume on the transition risk for psychosis.
CI  - Copyright (c) 2021 Hinney, Walter, Aghlmandi, Andreou and Borgwardt.
FAU - Hinney, Bernd
AU  - Hinney B
AD  - Department of Psychiatry (UPK), University of Basel, Basel, Switzerland.
FAU - Walter, Anna
AU  - Walter A
AD  - Department of Psychiatry (UPK), University of Basel, Basel, Switzerland.
FAU - Aghlmandi, Soheila
AU  - Aghlmandi S
AD  - Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital 
      Basel, Basel, Switzerland.
FAU - Andreou, Christina
AU  - Andreou C
AD  - Department of Psychiatry (UPK), University of Basel, Basel, Switzerland.
FAU - Borgwardt, Stefan
AU  - Borgwardt S
AD  - Department of Psychiatry (UPK), University of Basel, Basel, Switzerland.
LA  - eng
PT  - Systematic Review
DEP - 20210114
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC7840882
OTO - NOTNLM
OT  - at-risk mental state
OT  - high risk
OT  - hippocampus
OT  - neuroimaging
OT  - psychosis
OT  - schizophrenia
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/02/02 06:00
MHDA- 2021/02/02 06:01
PMCR- 2021/01/14
CRDT- 2021/02/01 05:54
PHST- 2020/10/06 00:00 [received]
PHST- 2020/12/14 00:00 [accepted]
PHST- 2021/02/01 05:54 [entrez]
PHST- 2021/02/02 06:00 [pubmed]
PHST- 2021/02/02 06:01 [medline]
PHST- 2021/01/14 00:00 [pmc-release]
AID - 10.3389/fpsyt.2020.614659 [doi]
PST - epublish
SO  - Front Psychiatry. 2021 Jan 14;11:614659. doi: 10.3389/fpsyt.2020.614659. 
      eCollection 2020.