PMID- 33520078
OWN - NLM
STAT- MEDLINE
DCOM- 20210302
LR  - 20210302
IS  - 1937-8688 (Electronic)
VI  - 38
DP  - 2021
TI  - Thrombocytopenia induced by glycoprotein (GP) IIb-IIIa antagonists: about two 
      cases.
PG  - 9
LID - 10.11604/pamj.2021.38.9.27215 [doi]
LID - 9
AB  - In this paper, we report two cases of induced thrombocytopenia after the infusion 
      of glycoprotein (GP) IIb/IIIa receptors antagonists, following a coronary 
      angioplasty. The first patient is a 65-year-old woman, admitted with acute 
      coronary syndrome requiring percutaneous angioplasty with stenting. The patient 
      was given tirofiban + unfractionated heparin (UFH). Ten hours later, the patient 
      revealed very severe thrombocytopenia and went into hemorrhagic shock 
      (hematemesis and hematoma at the injection site). The patient was transfused with 
      nine units of red blood cells (RBCs), 24 platelets pellets and 4 units of fresh 
      frozen plasma (FFP). The second patient is a 76-year-old woman. She was admitted 
      to hospital for acute coronary syndrome necessitating percutaneous angioplasty 
      with stenting and a glycoprotein IIb/IIIa receptor antagonists, tirofiban + 
      unfractionated (UFH). Four hours later, the patient presented with gingivorrhagia 
      associated thrombocytopenia. She received six platelet pellets transfusion with 
      well clinical and biological improvement. These two observations raise the 
      significance of a close monitoring of platelet count after the initiation of GP 
      IIb/IIIa antagonists infusion, which are sometimes responsible for 
      life-threatening adverse events.
CI  - Copyright: Salma Abdeladim et al.
FAU - Abdeladim, Salma
AU  - Abdeladim S
AD  - Department of Cardiology, Cheick Khalifa International University Hospital, 
      Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
FAU - Elharras, Mahassine
AU  - Elharras M
AD  - Department of Cardiology, Cheick Khalifa International University Hospital, 
      Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
FAU - Elouarradi, Amal
AU  - Elouarradi A
AD  - Department of Cardiology, Cheick Khalifa International University Hospital, 
      Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
FAU - Bensahi, Ilham
AU  - Bensahi I
AD  - Department of Cardiology, Cheick Khalifa International University Hospital, 
      Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
FAU - Oualim, Sara
AU  - Oualim S
AD  - Department of Cardiology, Cheick Khalifa International University Hospital, 
      Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
FAU - Merzouk, Fatimazahra
AU  - Merzouk F
AD  - Department of Cardiology, Cheick Khalifa International University Hospital, 
      Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
FAU - Sabry, Mohamed
AU  - Sabry M
AD  - Department of Cardiology, Cheick Khalifa International University Hospital, 
      Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
LA  - eng
PT  - Case Reports
DEP - 20210105
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
RN  - 0 (Anticoagulants)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Platelet Glycoprotein GPIIb-IIIa Complex)
RN  - 9005-49-6 (Heparin)
RN  - GGX234SI5H (Tirofiban)
SB  - IM
MH  - Aged
MH  - Angioplasty, Balloon, Coronary
MH  - Anticoagulants/administration & dosage/adverse effects
MH  - Female
MH  - Heparin/administration & dosage/adverse effects
MH  - Humans
MH  - Plasma
MH  - Platelet Aggregation Inhibitors/administration & dosage/*adverse effects
MH  - Platelet Glycoprotein GPIIb-IIIa Complex/*antagonists & inhibitors
MH  - Platelet Transfusion
MH  - Thrombocytopenia/*chemically induced/therapy
MH  - Tirofiban/administration & dosage/*adverse effects
PMC - PMC7825373
OTO - NOTNLM
OT  - Glycoprotein IIb/IIIa receptor antagonist
OT  - case report
OT  - thrombocytopenia
OT  - tirofiban
COIS- The authors declare no competing interests.
EDAT- 2021/02/02 06:00
MHDA- 2021/03/03 06:00
PMCR- 2021/01/05
CRDT- 2021/02/01 05:56
PHST- 2020/11/29 00:00 [received]
PHST- 2020/12/10 00:00 [accepted]
PHST- 2021/02/01 05:56 [entrez]
PHST- 2021/02/02 06:00 [pubmed]
PHST- 2021/03/03 06:00 [medline]
PHST- 2021/01/05 00:00 [pmc-release]
AID - PAMJ-38-9 [pii]
AID - 10.11604/pamj.2021.38.9.27215 [doi]
PST - epublish
SO  - Pan Afr Med J. 2021 Jan 5;38:9. doi: 10.11604/pamj.2021.38.9.27215. eCollection 
      2021.