PMID- 33520463
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2167-8359 (Print)
IS  - 2167-8359 (Electronic)
IS  - 2167-8359 (Linking)
VI  - 9
DP  - 2021
TI  - The association between serum uric acid and diabetic complications in patients 
      with type 2 diabetes mellitus by gender: a cross-sectional study.
PG  - e10691
LID - 10.7717/peerj.10691 [doi]
LID - e10691
AB  - BACKGROUND: The relationship between serum uric acid (SUA) and several diabetic 
      complications or co-morbidities remains a matter of debate. The study aims to 
      explore the association between SUA levels and the prevalence of non-alcoholic 
      fatty liver disease (NAFLD), diabetic retinopathy (DR), diabetic nephropathy (DN) 
      and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes 
      mellitus (T2DM). METHODS: A total of 2,809 participants (1,784 males and 1,025 
      females) were included in this cross-sectional study. Clinical characteristics 
      and the prevalence of each of the four diseases were analyzed based on 
      gender-specific quartiles of SUA levels. The Pearson correlation analysis and 
      linear-regression analysis were used to access the correlation between SUA levels 
      and clinical characteristics. Furthermore, a binary logistic regression analysis 
      was carried out to determine whether SUA was an independent risk factor for each 
      of the four complications. RESULTS: SUA levels were positively correlated to BMI, 
      BUN, Scr and TG, but negatively associated with eGFR, HDL, FBG, 2h-PG and HbA1c% 
      for the patients with T2DM. The prevalence of NAFLD and DN, but not DR or DPN, 
      were increased with SUA levels from the first to the fourth quartile. Binary 
      logistic regression further disclosed that SUA was an independent risk factor for 
      NAFLD (ORs Male = 1.002, ( *) P = 0.0013; ORs Female = 1.002, ( *) P = 0.015) and 
      DN (ORs Male = 1.006, ( *) P < 0.001; ORs Female = 1.005, ( *) P < 0.001), but not 
      for DR and DPN. After adjustment for the confounders, SUA levels were 
      significantly associated with NAFLD within the 3rd (ORs = 1.829, P = 0.004) and 
      4th quartile (ORs = 2.064, P = 0.001) for women, but not independently associated 
      with SUA for man. On the other hand, our results revealed increased prevalence of 
      DN for SUA quartile 2 (ORs = 3.643, P = 0.039), quartile 3 (ORs = 3.967, 
      P = 0.024) and quartile 4 (ORs = 9.133, P < 0.001) in men; however, SUA quartiles 
      were significantly associated with DN only for quartile 4 (ORs = 4.083, 
      P = 0.042) in women. CONCLUSION: For patients with T2DM, elevated SUA 
      concentration is an independent risk factor for the prevalence of NAFLD and DN 
      after adjustment for other indicators, but not DR or DPN.
CI  - (c)2021 Hu et al.
FAU - Hu, Yimeng
AU  - Hu Y
AD  - Department of Endocrinology & Metabolism, Renmin Hospital of Wuhan University, Wu 
      Han, Hu Bei, China.
FAU - Li, Qinge
AU  - Li Q
AD  - Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan, China.
FAU - Min, Rui
AU  - Min R
AD  - Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan, China.
FAU - Deng, Yingfeng
AU  - Deng Y
AD  - Department of Internal Medicine, University of Texas Southwestern Medical Center, 
      TX, USA.
FAU - Xu, Yancheng
AU  - Xu Y
AD  - Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan, China.
FAU - Gao, Ling
AU  - Gao L
AD  - Department of Endocrinology & Metabolism, Renmin Hospital of Wuhan University, Wu 
      Han, Hu Bei, China.
LA  - eng
PT  - Journal Article
DEP - 20210113
PL  - United States
TA  - PeerJ
JT  - PeerJ
JID - 101603425
PMC - PMC7811288
OTO - NOTNLM
OT  - Diabetic nephropathy
OT  - Diabetic peripheral neuropathy
OT  - Diabetic retinopathy
OT  - Non-alcoholic fatty liver disease
OT  - Serum uric acid
COIS- The authors declare there are no competing interests.
EDAT- 2021/02/02 06:00
MHDA- 2021/02/02 06:01
PMCR- 2021/01/13
CRDT- 2021/02/01 05:58
PHST- 2020/08/24 00:00 [received]
PHST- 2020/12/11 00:00 [accepted]
PHST- 2021/02/01 05:58 [entrez]
PHST- 2021/02/02 06:00 [pubmed]
PHST- 2021/02/02 06:01 [medline]
PHST- 2021/01/13 00:00 [pmc-release]
AID - 10691 [pii]
AID - 10.7717/peerj.10691 [doi]
PST - epublish
SO  - PeerJ. 2021 Jan 13;9:e10691. doi: 10.7717/peerj.10691. eCollection 2021.