PMID- 33523775
OWN - NLM
STAT- MEDLINE
DCOM- 20210422
LR  - 20210422
IS  - 1751-2441 (Electronic)
IS  - 1751-2433 (Linking)
VI  - 14
IP  - 3
DP  - 2021 Mar
TI  - Efficacy and safety of injectable deoxycholic acid for submental fat reduction: a 
      systematic review and meta-analysis of randomized controlled trials.
PG  - 383-397
LID - 10.1080/17512433.2021.1884070 [doi]
AB  - Objective: To investigate the efficacy and safety of deoxycholic acid (DOC) for 
      SMF reduction.Methods: We conducted a systematic review and meta-analysis of 
      randomized controlled trials. We searched PubMed/MEDLINE, EMBASE, and Cochrane 
      databases until June 2020. Efficacy outcomes: Clinician-Reported Submental Fat 
      Rating Scale; Patient-Reported Submental Fat Rating Scale; Subject Self-Rating 
      Scale; SMF reduction measured using caliper and resonance magnetic imaging; Early 
      therapeutic success. Safety outcomes: Withdrawals due to adverse events (AEs), 
      Rates of AEs, Skin laxity.Results: Five studies were included, comprising 1,838 
      participants. DOC (1 or 2 mg/cm(2)) had greater improvement in all efficacy 
      measures compared to placebo. No differences were seen between both doses of DOC. 
      Withdrawals due to AEs were low with 1 and 2 mg/cm(2) of DOC (6.8% vs. 9.9%, 
      respectively), and there was no difference between the two doses (p = 0.22). AEs 
      were usually associated with the injection site, were predominantly transient, 
      and commonly resolved within the treatment session interval. Injection site pain, 
      hematoma, anesthesia/numbness, erythema, and swelling/edema were the most common 
      AEs. There was no difference in their prevalence between both doses of 
      DOC.Conclusions: DOC is effective and safe for SMF reduction with no differences 
      between doses of 1 and 2 mg/cm(2).
FAU - Cunha, Karin Soares
AU  - Cunha KS
AD  - Postgraduate Program in Pathology, Medical School, Universidade Federal 
      Fluminense, UFF, Niteroi, Rio De Janeiro, Brazil.
AD  - Department of Pathology, Medical School, Universidade Federal Fluminense, UFF, 
      Niteroi, Brazil.
FAU - Lima, Flavia
AU  - Lima F
AD  - Private Practice, Niteroi, Rio De Janeiro, Brazil.
FAU - Cardoso, Roberta Marques
AU  - Cardoso RM
AD  - Specialization Course of Orofacial Harmonization, Centro Universitario Avantis/SM 
      Odontologia, Niteroi, Rio De Janeiro, Brazil.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20210213
PL  - England
TA  - Expert Rev Clin Pharmacol
JT  - Expert review of clinical pharmacology
JID - 101278296
RN  - 0 (Cholagogues and Choleretics)
RN  - 005990WHZZ (Deoxycholic Acid)
SB  - IM
MH  - Chin
MH  - Cholagogues and Choleretics/administration & dosage/adverse effects
MH  - *Cosmetic Techniques
MH  - Deoxycholic Acid/*administration & dosage/adverse effects
MH  - Humans
MH  - Injections, Subcutaneous
MH  - Magnetic Resonance Imaging
MH  - Neck
MH  - Randomized Controlled Trials as Topic
MH  - Subcutaneous Fat/*drug effects
OTO - NOTNLM
OT  - ATX-101
OT  - deoxycholate
OT  - deoxycholic acid
OT  - efficacy
OT  - safety
OT  - submental fat
EDAT- 2021/02/02 06:00
MHDA- 2021/04/23 06:00
CRDT- 2021/02/01 17:10
PHST- 2021/02/02 06:00 [pubmed]
PHST- 2021/04/23 06:00 [medline]
PHST- 2021/02/01 17:10 [entrez]
AID - 10.1080/17512433.2021.1884070 [doi]
PST - ppublish
SO  - Expert Rev Clin Pharmacol. 2021 Mar;14(3):383-397. doi: 
      10.1080/17512433.2021.1884070. Epub 2021 Feb 13.