PMID- 33524127
OWN - NLM
STAT- MEDLINE
DCOM- 20210928
LR  - 20231112
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 106
IP  - 5
DP  - 2021 Apr 23
TI  - Cardiometabolic Profile of Different Body Composition Phenotypes in Children.
PG  - e2015-e2024
LID - 10.1210/clinem/dgab003 [doi]
AB  - CONTEXT: Cardiometabolic profiles of different body composition phenotypes are 
      poorly characterized in young children, where it is well established that high 
      adiposity is unfavorable, but the role of lean mass is unclear. OBJECTIVE: We 
      hypothesized that higher lean mass attenuates cardiometabolic risk in children 
      with high fat mass. METHODS: In 6-year-old children (n = 377) from the Growing Up 
      in Singapore Towards healthy Outcomes (GUSTO) prospective birth cohort, 
      whole-body composition was measured by quantitative magnetic resonance, a novel 
      validated technology. Based on fat mass index (FMI) and lean mass index (LMI), 4 
      body composition phenotypes were derived: low FMI-low LMI (LF-LL), low FMI-high 
      LMI (LF-HL), high FMI-low LMI (HF-LL), high FMI-high LMI (HF-HL). MAIN OUTCOME 
      MEASURES: Body mass index (BMI) z-score, fasting plasma glucose, insulin 
      resistance, metabolic syndrome risk score, fatty liver index, and blood pressure. 
      RESULTS: Compared with the LF-HL group, children in both high FMI groups had 
      increased BMI z-score (HF-HL: 1.43 units 95% CI [1.11,1.76]; HF-LL: 0.61 units 
      [0.25,0.96]) and metabolic syndrome risk score (HF-HL: 1.64 [0.77,2.50]; HF-LL: 
      1.28 [0.34,2.21]). The HF-HL group also had increased fatty liver index (1.15 
      [0.54,1.77]). Girls in HF-HL group had lower fasting plasma glucose (-0.29 mmol/L 
      [-0.55,-0.04]) and diastolic blood pressure (-3.22 mmHg [-6.03,-0.41]) than girls 
      in the HF-LL group. No similar associations were observed in boys. CONCLUSION: In 
      a multi-ethnic Asian cohort, lean mass seemed to protect against some 
      cardiometabolic risk markers linked with adiposity, but only in girls. The FMI 
      seemed more important than lean mass index in relation to cardiometabolic 
      profiles of young children.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      Endocrine Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Ong, Yi Ying
AU  - Ong YY
AD  - Department of Paediatrics, Yong Loo Lin School of Medicine, National University 
      of Singapore, Singapore, Singapore.
FAU - Huang, Jonathan Y
AU  - Huang JY
AD  - Singapore Institute for Clinical Sciences, Agency for Sciences, Technology, and 
      Research, Singapore, Singapore.
FAU - Michael, Navin
AU  - Michael N
AD  - Singapore Institute for Clinical Sciences, Agency for Sciences, Technology, and 
      Research, Singapore, Singapore.
FAU - Sadananthan, Suresh Anand
AU  - Sadananthan SA
AD  - Singapore Institute for Clinical Sciences, Agency for Sciences, Technology, and 
      Research, Singapore, Singapore.
FAU - Yuan, Wen Lun
AU  - Yuan WL
AD  - Department of Paediatrics, Yong Loo Lin School of Medicine, National University 
      of Singapore, Singapore, Singapore.
FAU - Chen, Ling-Wei
AU  - Chen LW
AD  - Singapore Institute for Clinical Sciences, Agency for Sciences, Technology, and 
      Research, Singapore, Singapore.
FAU - Karnani, Neerja
AU  - Karnani N
AD  - Singapore Institute for Clinical Sciences, Agency for Sciences, Technology, and 
      Research, Singapore, Singapore.
FAU - Velan, S Sendhil
AU  - Velan SS
AD  - Singapore Institute for Clinical Sciences, Agency for Sciences, Technology, and 
      Research, Singapore, Singapore.
AD  - Singapore Bioimaging Consortium, Agency for Science Technology and Research, 
      Singapore, Singapore.
FAU - Fortier, Marielle V
AU  - Fortier MV
AD  - Singapore Institute for Clinical Sciences, Agency for Sciences, Technology, and 
      Research, Singapore, Singapore.
AD  - Department of Diagnostic and Interventional Imaging, KK Women's and Children's 
      Hospital, Singapore, Singapore.
FAU - Tan, Kok Hian
AU  - Tan KH
AD  - Duke-NUS Medical School, Singapore, Singapore.
AD  - Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, 
      Singapore, Singapore.
FAU - Gluckman, Peter D
AU  - Gluckman PD
AD  - Singapore Institute for Clinical Sciences, Agency for Sciences, Technology, and 
      Research, Singapore, Singapore.
AD  - Liggins Institute, University of Auckland, Auckland, New Zealand.
FAU - Yap, Fabian
AU  - Yap F
AD  - Duke-NUS Medical School, Singapore, Singapore.
AD  - Department of Paediatrics, KK Women's and Children's Hospital, Singapore, 
      Singapore.
FAU - Chong, Yap-Seng
AU  - Chong YS
AD  - Singapore Institute for Clinical Sciences, Agency for Sciences, Technology, and 
      Research, Singapore, Singapore.
AD  - Department of Obstetrics and Gynaecology and Human Potential Translational 
      Research Programme, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore, Singapore.
FAU - Godfrey, Keith M
AU  - Godfrey KM
AD  - MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, 
      University of Southampton and University Hospital Southampton NHS Foundation 
      Trust, Southampton, UK.
FAU - Chong, Mary F-F
AU  - Chong MF
AD  - Singapore Institute for Clinical Sciences, Agency for Sciences, Technology, and 
      Research, Singapore, Singapore.
AD  - Saw Swee Hock School of Public Health, National University of Singapore, 
      Singapore, Singapore.
FAU - Chan, Shiao-Yng
AU  - Chan SY
AD  - Singapore Institute for Clinical Sciences, Agency for Sciences, Technology, and 
      Research, Singapore, Singapore.
AD  - Department of Obstetrics and Gynaecology and Human Potential Translational 
      Research Programme, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore, Singapore.
FAU - Lee, Yung Seng
AU  - Lee YS
AD  - Department of Paediatrics, Yong Loo Lin School of Medicine, National University 
      of Singapore, Singapore, Singapore.
AD  - Singapore Institute for Clinical Sciences, Agency for Sciences, Technology, and 
      Research, Singapore, Singapore.
AD  - Division of Paediatric Endocrinology, Department of Paediatrics, Khoo Teck 
      Puat-National University Children's Medical Institute, National University 
      Hospital, National University Health System, Singapore.
FAU - Tint, Mya-Thway
AU  - Tint MT
AD  - Singapore Institute for Clinical Sciences, Agency for Sciences, Technology, and 
      Research, Singapore, Singapore.
AD  - Department of Obstetrics and Gynaecology and Human Potential Translational 
      Research Programme, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore, Singapore.
AD  - Folkhalsan Research Center, Helsinki, Finland.
FAU - Eriksson, Johan G
AU  - Eriksson JG
AD  - Singapore Institute for Clinical Sciences, Agency for Sciences, Technology, and 
      Research, Singapore, Singapore.
AD  - Department of Obstetrics and Gynaecology and Human Potential Translational 
      Research Programme, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore, Singapore.
AD  - Department of General Practice and Primary Health Care, University of Helsinki 
      and Helsinki University Hospital, Helsinki, Finland.
AD  - Folkhalsan Research Center, Helsinki, Finland.
LA  - eng
GR  - NF-SI-0515-10042/DH_/Department of Health/United Kingdom
GR  - RG/15/17/31749/BHF_/British Heart Foundation/United Kingdom
GR  - MC_PC_21000/MRC_/Medical Research Council/United Kingdom
GR  - 17/63/154/DH_/Department of Health/United Kingdom
GR  - MC_PC_21001/MRC_/Medical Research Council/United Kingdom
GR  - MC_PC_21003/MRC_/Medical Research Council/United Kingdom
GR  - RG/15/17/3174/BHF_/British Heart Foundation/United Kingdom
GR  - IS-BRC-1215-20004/DH_/Department of Health/United Kingdom
GR  - MC_UU_12011/4/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
SB  - IM
MH  - *Adiposity
MH  - Adult
MH  - *Body Composition
MH  - *Body Mass Index
MH  - Cardiovascular Diseases/*epidemiology
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant, Newborn
MH  - *Insulin Resistance
MH  - Male
MH  - Metabolic Syndrome/*epidemiology
MH  - Obesity/*physiopathology
MH  - Prognosis
MH  - Prospective Studies
MH  - Singapore/epidemiology
PMC - PMC7610678
MID - EMS118287
OTO - NOTNLM
OT  - Body composition
OT  - adiposity
OT  - cardiometabolic
OT  - lean
OT  - metabolic syndrome
EDAT- 2021/02/02 06:00
MHDA- 2021/09/29 06:00
PMCR- 2021/10/23
CRDT- 2021/02/01 17:13
PHST- 2020/10/15 00:00 [received]
PHST- 2021/02/02 06:00 [pubmed]
PHST- 2021/09/29 06:00 [medline]
PHST- 2021/02/01 17:13 [entrez]
PHST- 2021/10/23 00:00 [pmc-release]
AID - 6125727 [pii]
AID - 10.1210/clinem/dgab003 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2021 Apr 23;106(5):e2015-e2024. doi: 
      10.1210/clinem/dgab003.