PMID- 33524801
OWN - NLM
STAT- MEDLINE
DCOM- 20210528
LR  - 20210528
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 93
DP  - 2021 Apr
TI  - Epigallocatechin-3-gallate prevents inflammation and diabetes -Induced glucose 
      tolerance through inhibition of NLRP3 inflammasome activation.
PG  - 107412
LID - S1567-5769(21)00048-5 [pii]
LID - 10.1016/j.intimp.2021.107412 [doi]
AB  - Epigallocatechin-3-gallate (EGCG), the primary polyphenol component of green tea, 
      has been shown to inhibit both oxidation and inflammation. However, the exact 
      mechanism through which EGCG exhibits anti-inflammatory effects remains unclear. 
      In this study, we assessed the potential pathways by which EGCG regulates NLRP3 
      inflammasome activity in vitro. We found that EGCG inhibits caspase-1 activation 
      and IL-1beta secretion by suppressing NLRP3 inflammasome activation in mouse bone 
      marrow-derived macrophages (BMDMs). EGCG was also observed to block 
      NLRP3-mediated ASC speckle formation and to alleviate pyroptosis in BMDMs. In 
      addition, EGCG treatment could improve high-fat diet (HFD)-induced glucose 
      tolerance and prevent NLRP3 inflammasome-dependent inflammation in a mouse model 
      of HFD-induced type 2 diabetes (T2D). Taken together, our results show that EGCG 
      is a general inhibitor of NLRP3 inflammasome activation and administration of 
      EGCG in T2D mice could improve glucose tolerance in vivo.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Zhang, Cheng
AU  - Zhang C
AD  - Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong 
      University, Jinan, China.
FAU - Li, Xin
AU  - Li X
AD  - Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong 
      University, Jinan, China.
FAU - Hu, Xiang
AU  - Hu X
AD  - Shandong Provincial Key Laboratory of Immunohematology, Qilu Hospital, Cheeloo 
      College of Medicine, Shandong University, Jinan, China.
FAU - Xu, Qirui
AU  - Xu Q
AD  - Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong 
      University, Jinan, China.
FAU - Zhang, Yanqi
AU  - Zhang Y
AD  - Shandong Provincial Key Laboratory of Immunohematology, Qilu Hospital, Cheeloo 
      College of Medicine, Shandong University, Jinan, China.
FAU - Liu, Hongyan
AU  - Liu H
AD  - Institute of Basic Medicine, Shandong First Medical University & Shandong Academy 
      of Medical Sciences, Jinan, China.
FAU - Diao, Yutao
AU  - Diao Y
AD  - Institute of Basic Medicine, Shandong First Medical University & Shandong Academy 
      of Medical Sciences, Jinan, China.
FAU - Zhang, Xiaoyu
AU  - Zhang X
AD  - Institute of Basic Medicine, Shandong First Medical University & Shandong Academy 
      of Medical Sciences, Jinan, China.
FAU - Li, Lianlian
AU  - Li L
AD  - Institute of Basic Medicine, Shandong First Medical University & Shandong Academy 
      of Medical Sciences, Jinan, China.
FAU - Yu, Jie
AU  - Yu J
AD  - Department of Hematology, Weihai Municipal Hospital, Weihai, China.
FAU - Yin, Haipeng
AU  - Yin H
AD  - Institute of Basic Medicine, Shandong First Medical University & Shandong Academy 
      of Medical Sciences, Jinan, China. Electronic address: 149578830@qq.com.
FAU - Peng, Jun
AU  - Peng J
AD  - Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong 
      University, Jinan, China. Electronic address: junpeng88@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20210130
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Inflammasomes)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 8R1V1STN48 (Catechin)
RN  - BQM438CTEL (epigallocatechin gallate)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Bone Marrow/*pathology
MH  - Catechin/*analogs & derivatives/therapeutic use
MH  - Cells, Cultured
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Diet, High-Fat
MH  - Disease Models, Animal
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Inflammasomes/*metabolism
MH  - Inflammation/*drug therapy
MH  - Macrophages/*immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/metabolism
MH  - Pyroptosis
OTO - NOTNLM
OT  - ASC
OT  - EGCG
OT  - Glucose tolerance
OT  - IL-1beta
OT  - Inflammasome
OT  - NLRP3
EDAT- 2021/02/02 06:00
MHDA- 2021/05/29 06:00
CRDT- 2021/02/01 20:15
PHST- 2020/10/29 00:00 [received]
PHST- 2021/01/06 00:00 [revised]
PHST- 2021/01/16 00:00 [accepted]
PHST- 2021/02/02 06:00 [pubmed]
PHST- 2021/05/29 06:00 [medline]
PHST- 2021/02/01 20:15 [entrez]
AID - S1567-5769(21)00048-5 [pii]
AID - 10.1016/j.intimp.2021.107412 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2021 Apr;93:107412. doi: 10.1016/j.intimp.2021.107412. Epub 
      2021 Jan 30.